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A reciprocal metabolism pattern was represented between cortices and paralimic regions, which implicated a reciprocal dysfunctional changes of paralimic-cortex pathway in patients with TRD. Cerebellar hypermetabolism suggested hyperfunctional changes of cerebellum under depressed condition. Frontal white matter hypermetabolism implicated further studies on potential structural abnormalities of cerebral regions in TRD.

难治性抑郁症患者存在旁边缘系统代谢增高和皮质代谢降低的交互性代谢改变模式,支持抑郁症边缘系统-皮质功能紊乱假说;患者小脑代谢水平增高,提示抑郁状态下小脑功能亢进;额叶白质高代谢水平提示有必要对难治性抑郁症潜在的脑结构异常改变进行深入研究。

The opioid receptors mainly distribute at prefrontal lobe(obitofrontal gyrus, medial superior frontal gyrus, superior frontal gyrus), paralimbic cortices (cingulated cortex and hippocampus), insular cortex、pallidum and the opercular section of frontal lobe and parietal lobe. These results corresponded with the classic theories on PET neurorecepotors imaging.

通过phfMRI方法进一步验证了人脑中枢系统内阿片受体的主要分布区,其中皮层区集中在前额叶(眶额皮质、额上回、额内上回)、边缘系统、颞叶脑岛区及额顶叶的岛盖部;皮层下区集中在苍白球区;小脑集中在小脑皮层、小脑脚及小脑蚓部。

The fibres of the corticospinal tract, which run craniocaudally in the dorsal pons, the pontine tegmentum, and the superior cerebellar peduncles ventrally, were all preserved, this differential involvement therefore being responsible for the cruciform appearance on MRI.

译:脑桥神经元和横桥纤维严重减少,造成脑桥基底部和小脑中脚的苍白和萎缩。上下走行于脑桥背侧的皮质脊髓束、脑桥背盖部、腹前侧的小脑上脚/结合臂均未受累。这种差异性受累是MRI上出现十字征的原因。

The results suggested that AC-cAMP-PDE pathway in cerebellum did not participate in regulating the anesthetic action, but perhaps correlated with ethological changes (such as behavior mis match and orientating function handicapped) during recovery period.

4临床相关剂量的噻拉唑和QFM合剂对大鼠大脑皮质、海马、脑干和小脑的PDE活性无影响,结果说明,大脑皮质、海马、脑干和小脑AC-cAMP-PDE信息传递系统对噻拉唑和QFM合剂麻醉作用的调控不是通过PDE对cAMP的降解作用,而是通过其它途径(如通过调节AC的活性影响cAMP的生成环节)来调控cAMP的产量实现的。

They include cerebellum,cerebral cortex,hypothalamus, mesencephalon, and pons.A few of positive cells could be seen in the medulla oblongata. NADPH-d positive neurons appears blue.Their shapes were diversform such as polygon,fusiform,nummular and oval etc. Karyon hasn't pigmentation. Dendriate and axon's pigmentation are clear.

实验一利用NADPH-d酶组织化学技术,对NOS阳性神经元在兔脑的总体分布规律及其衰老性变化进行了系统研究,结果表明:①NADPH-d阳性神经元分布于兔脑各个部位,几乎涉及所有区域:包括小脑、大脑皮质、丘脑下部、中脑、脑桥和小脑,而延髓分布较少。

Of the 26 lesions with pontine and bulbar involvement, three had no association with other lesions (Fig 2). Twelve were associated with tegmental and superior cerebellar peduncular extension, and six showed corticospinal tract involvement in continuity with an MDJ lesion. In one patient with additional telencephalic lesions, the right side of the pons was hyperintense on long TR/TE images that did not cross the midline, suggestive of an arterial lesion (Fig 3). In two patients with pontine tegmental lesions, there was an associated middle cerebellar peduncle and deep cerebellar white matter involvement (Fig 4). Two others had associated cervical lesions.

在26处脑桥延髓区病灶中,3处病灶仅限于脑桥延髓区,其它部位无病灶(图2);12处病灶还同时伴有背盖部和小脑上脚/结合臂处病灶;6处病灶为与中脑-间脑接合处病灶相连的皮质脊髓束受累;还有1例患者除端脑见病灶外,右侧脑桥于T2像也见高信号病灶,但未超越正中线,提示可能系动脉病变所致(图3);2例脑桥背盖部病灶的患者同时伴有小脑中脚/小脑脑桥脚和小脑深部白质受累(图4);还有2处脑桥延髓区病灶还同时伴有颈髓病灶。

In the granular layer, the perinuclear space of granular cell was clear and with little cytoplasm.

结果表明小脑皮质从外向内依次可分为分子层、蒲肯野细胞层和颗粒层。

Somatotopic localization of the sensorimotor functions in the cerebellar cortex of a monkey.

猴子的小脑皮质区与特定感觉运动功能的局部化。

Usually these are found in the subcortical and central white matter and cortical gray-white junction of both cerebral hemispheres , cerebellum , brainstem , and spinal cord [11] , but periventricular white matter and gray matter of the cortex , thalami and basal ganglia may also be involved.

通常,这些被发现的皮质和中央白质和皮质灰色白色双方交界处的大脑半球,小脑,脑干和脊髓[ 11 ] ,但周围白质和灰质的皮质,丘脑和基底节也可参与。

The results showed that the cerebellum was divided into hemisphere and vermis at April of embrya.

结果发现从胚胎4月开始,小脑已由两侧的小脑半球和蚓部组成,可见皮质和髓质。

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