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METHODS AND FINDINGS: A boy with ataxia telangiectasia was treated with intracerebellar and intrathecal injection of human fetal neural stem cells.

方法和结果:一名患运动失调性毛细血管扩张症的男孩接受了小脑内和鞘内人胚胎神经干细胞注射治疗。

The suboccipital retrosigmoid approach was used on 10 adult head specimens which were fixed and perfused with color silicon, the neurovascular structures and their relationship in cere- bellopontine angles were observed under the operative microscope and endoscope.

选择经10%福尔马林充分固定,血管内灌注混有红、蓝染料的乳胶,不分性别的成人尸头10具,模拟目前临床上最长使用的枕下乙状窦后入路,在手术显微镜和神经内窥镜下,观察小脑桥脑角内的神经血管结构,确认这些神经血管的走行及其之间的解剖关系。

The effects of estrogen on the expression of ER, NGF and ChAT in rats cerebellum were studied in this paper.

本研究旨在探讨雌激素对大鼠小脑内雌激素受体、神经生长因子和胆碱乙酰转移酶表达的影响。

Results (1) 6 cases of Tuberous Sclerosis. Diffused subependymal nodular calcification lesions were found in all cases on unenhenced CT. 4 patients are 2 pairs of mother/child relationship. Both of the two mothers are found to suffer from renal angiomyolipoma.(2)1 case of neurofibromatosis showed abnormal spinal canal: scoliosis of thoracic and lumbar spine, concave change of vertebral posterior border. Bilateral renal hypogenesis was found in this patient. Diffused hyper-density lesions were found in kidney and fatty accumulation was found in back skin.(3)6 cases of Sturge-Weber syndrome. On unenhenced CT, curving and strip-shaped calcifications were found along the parietal and occipital gyrus.

结果 ①结节性硬化6例,所有病例CT平扫见两侧脑室室管膜下多发小结节状高密度钙化灶,其中4例为两对母子关系,并见两位母亲合并有肾脏错构瘤,;②神经纤维瘤病1例,MRI表现为椎管异常,胸腰段脊柱侧弯,椎体后缘呈明显的切凹改变;伴有双肾发育不良,CT示肾内多个高密度影,背部皮肤多量脂肪堆积,③脑颜面血管瘤综合征6例, CT可见顶枕部沿脑回分布的弯曲的条状高密度钙化,部分延伸致侧脑室内,增强后见病灶内有扭曲的条状和结节状明显强化的血管影;④小脑血管瘤病4例,影像学表现为小脑内大囊、小结节样占位性病变。

The opioid receptors mainly distribute at prefrontal lobe(obitofrontal gyrus, medial superior frontal gyrus, superior frontal gyrus), paralimbic cortices (cingulated cortex and hippocampus), insular cortex、pallidum and the opercular section of frontal lobe and parietal lobe. These results corresponded with the classic theories on PET neurorecepotors imaging.

通过phfMRI方法进一步验证了人脑中枢系统内阿片受体的主要分布区,其中皮层区集中在前额叶(眶额皮质、额上回、额内上回)、边缘系统、颞叶脑岛区及额顶叶的岛盖部;皮层下区集中在苍白球区;小脑集中在小脑皮层、小脑脚及小脑蚓部。

The antibodies to cathepsin D and glial fibrillary acid protein and immunohistochemical PAP technique were used to observe the changes in microglia and astrocytes in the cerebella from NPC and normal mice of different ages.

应用组织蛋白酶D和胶质原纤维酸性蛋白抗体以及免疫组织化学方法,观察生后不同年龄的NPC和正常小鼠小脑内小胶质细胞和星形胶质细胞的变化。

The results show as follows:(1) immunoreactive neurons of NPY in pigeon cerebellum tire mainly located in the Purkinje cell layer of the cerebellar cortex, especially in the top of Purkinje cell in cerebellar folia:(2) a few neuropeptide Y immunoreactive neurons are observed in the central nuclei of cerebellar white matter .which is different from silky fowl, chick and rat;(3) none of neuropeptide Y immunoreactive neurons are found both in the molecular and granular layer.

结果显示:(1)小脑内神经肽Y(neuropeptide Y,NPY)阳性神经元主要存在于小脑皮质的蒲肯野氏细胞层,且以小叶顶端的蒲肯野氏细胞阳性明显;(2)小脑白质中央核可见到少量阳性神经元,不同于乌鸡、肉鸡及大鼠;(3)分子层、颗粒层未见阳性反应细胞。

Because of entirely intracerebellar growth, meningeal origin is also unlikely.

由于肿瘤完全在小脑内生长,所以也不太可能是脑膜起源的肿瘤。

The results are as follows:(1) immunoreactive neurons of NPY in medulla oblongata of Taihe silky fowl, New jianghan domestic chicken are mainly localized in the inferior olivary nucleus.

结果如下:(1)在泰和乌鸡和江汉鸡的延髓中,NPY阳性神经元主要存在于下橄榄核,网状核及中缝核也少量出现;(2)在泰和乌鸡和肉鸽的小脑中,NPY阳性神经元主要存在于小脑皮质的蒲肯野氏细胞层,且以小叶顶端的蒲肯野氏细胞阳性明显,而小脑皮质的分子层、颗粒层未见阳性反应细胞;(3)泰和乌鸡延髓的网状细胞核非常发达;泰和乌鸡小脑皮质分3层,由外至内依次为分子层、蒲肯野氏细胞层和颗粒层;小脑分10叶,Ⅰ、Ⅱ和Ⅹ为单叶,其余各叶都分为2~3个小叶;(4)非洲鸵鸟迷走神经运动背核和疑核特别发达,孤束核吻侧部不发达。

Results The histological observation of the cerebellar tissue in the animal experiment revealed that embryonic grafts could survive and that mitoses of the host Purkinje cells of the implanted group were increased substantially over the control groups.

在动物实验基础上,将胎龄为9~12周的人胚胎小脑组织悬液移植到6例患有严重小脑萎缩的患者脑内。

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