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A single point mutation in intervening sequence 2 (IVS2) of human mitochondrial arginyl-tRNA synthetase gene causes abnormal cleavage of its transcript, resulting in pontocerebellar hypoplasia.

人线粒体精氨酰-tRNA合成酶基因2号内含子中的一个单点突变导致该基因的转录本被异常剪接,造成脑桥小脑发育不全。

Compared to healthy controls, GTCS presented decreased gray matter volume in the bilateral thalamus, frontal lobe, insula and cerebellum regions. There were no regions showing significant increased gray matter volume. Correlation analysis revealed that bilateral thalamic, left medial frontal gyrus, left middle frontal gyrus and left precentral gyrus GMV had negative correlations with the frequecy of epilepsy.

通过GTCS患者组与正常对照组的比较,发现GTCS患者的双侧丘脑、双侧额叶、双侧岛叶、双侧小脑等区域的灰质体积有比较明显的减小,但没发现有意义的灰质体积增高的区域;患者双侧丘脑、左侧中央前回、左侧额内侧回、左侧额中回和其发病频率呈负相关,没有正相关的区域。

Result: The lesions preponderately located in the white matter of temporal lobe, brain stem and cerebellum, with irregular rim/nodular enhancement. All of the 3 MRS showed declined Cho and NAA peak.

结果:本组病例放射性脑损伤病灶主要位於颞叶、脑干及小脑照射野白质内,多呈不规则花环样或结节样强化。3例MRS均显示Cho及NAA下降。

Neuronalα4β2 nicotinic acetylcholine receptors are the most widespread subtypes in central nervous system.α4β2 nAChRs mainly exist in procerebrum, parietal lobe cortex, temporal lobe cortex, hippocampus, basal ganglion and cerebellum.

神经元烟碱受体α4β2亚型是中枢神经系统分布最为广泛的烟碱受体亚型,占脑内与烟碱有高亲和力的nAChRs的90%,主要分布在前脑、顶叶和颞叶皮质、海马、基底神经节和小脑

Other brain regions showing increasedpostsurgical activity were the contralateral parietal cortex,bilateral pulvinar and ipsilateral medial dorsal nucleus ofthe thalamus, contralateral putamen, contralateral superiortemporal gyrus, ipsilateral fusiform gyrus, ipsilateral posteriorlobe, and contralateral anterior cerebellar lobe.

术后活动性增强的大脑区域还有对侧的颅顶部的大脑皮层,两侧的丘脑后结节和下丘脑的背内侧核,对侧的壳核,对侧的上部颞侧脑回,同侧的梭状回,同侧的后叶和对侧的小脑前叶。

One set of projects in the lab explores a curious feature of the main output neurons of the cerebellum, the Purkinje cells.

我们研究组的一个研究方向是小脑中的一个主要输出神经元,浦肯野细胞。

1 This neuronal pathway is referred to as the cerebellum to Purkinje cell climbing fiber pathway and it is implicated in the coordination of movements.

1这种神经通路是关于小脑到蒲肯野细胞爬行纤维通路,提示与运动是一致的。

Whereas, the colocalization of PV with KCC2 could be detected in the Purkinje cell of the cerebellum as for the positive control experiments.

而在阳性对照实验中,在小脑的蒲肯野氏细胞层能观察到明显的KCC2的表达。

RNA interference experiences impliedthat cerebellum Purkinje cell after RNA interference have obviously apoptosis.

RNA干扰实验表明,RNA干扰后的小鼠小脑神经元出现明显的凋亡现象。

Resalt In these cases, the positions of hemorrhage of 64 patients were in lobe of brain; that of 33 patients was in basal ganglia; that of 29 patients was in cerebral ventricle and that of 9 patients was in cerebellum.

结果脑叶出血64例,基底节区出血33例,脑室出血29例,小脑出血9例DSA正常55例(占40.7%),异常80例(占59.3%),其中烟雾病43例、动-静脉畸形29例、动脉瘤6例、动-静脉瘘2例。8例复发性脑出血中DSA正常5例。

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