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Objective: To study the changes of the intrinsic electrophysiological characteristics of cerebellar Purkinje cells during the stage of the elevation of intracellular Ca(superscript 2+) through micro-injected of IP3 receptor excitomotor of Purkinje cells in cerebellar vermis.

目的:通过向细胞内微量注射IP3受体激动剂诱发细胞内高钙,探讨细胞内高钙对小鼠小脑浦肯野细胞内在电生理特性变化的影响。

Methods CT and MRI findings and data of 60 cases with subdural hematlmas atcerebral falx or tentorium of cerebellum were retrospectively analyzed.

回顾性分析总结60例大脑镰、小脑幕硬膜下血肿的CT和MRI资料。结果 60例中发生于

Through the analysis and comparison of CT amd MRI data of 60 cases with subdural hematomas at cerebral falx or tentorium of cerebellum,we get more and further knowledge about MRI can provide correct diagnosis by combining imaging and clinic contributing to eleviating diagnositic rate,and MRI is superior to CT in qualitative diagnosis.

通过60例大脑镰、小脑幕硬膜下血肿的CT、MRI表现的比较分析,得到了进一步的认识,有助于提高诊断符合率,MRI在定位诊断方面优于CT。

The stress distribution widespreadly and unequivalently in brain tissue, which mainly effect by the cerebelar tentorium, cerebral falx, and unregular geometry of cranial bone .

结论脑内质点应力差值致脑组织剪应变损伤,猫颅骨不规则的几何形状、小脑幕、大脑镰结构是导致旋转暴力向脑内传递广泛而不均一的主要原因。

Here, we show that mutations in GPR56, which encodes an orphan G protein–coupled receptor with a large extracellular domain, cause a human brain cortical malformation called bilateral frontoparietal polymicrogyria.

作者发现编码一个带有较大胞外区的孤儿G蛋白耦联受体的基因GPR56的突变导致人类大脑皮质畸形(双侧额顶多小脑回畸形BFPP)。

Except for classical regions involved in language actions, such as Wernicke and Broca areas, there appeared other activated cerebral regions, including cerebellum, limbic system and basal ganglial nucleus, etc. Various activation distribution patterns of cerebral regions were shared by every subject in both language tasks.

结果:所有受试者均出现显著的脑区激活,除传统语言脑区Wernicke和Broca区外,还出现其它脑区激活现象,如小脑、边缘系统、基底神经节等。

Results The Fos reactive products were distributed in the piriform cortex,accumbens nucleus,bed nucleus of stria terminalis, cingulate gyrus,nucleus of diagonal band, hypothalamic paraventricular nucleus, supraoptic nucleus, suprachiasmatic nucleus, arcuate nucleus, central amygdaloid, subfornical organ, paraventricular thalamic nucleus, lateral habenular nucleus,ventrolateral part of the central gray,lateral parabrachial nucleus,locus ceruleus,medullary visceral zone.

结果 Fos阳性产物分布于梨状皮质、伏核、终纹床核、扣带回、斜角带核、下丘脑室旁核、视上核、视交叉上核、弓状核、中央杏仁核、穹窿下器、丘脑室旁核、外侧缰核、中脑中央灰质腹外侧区、脑桥臂旁外侧核、蓝斑、延髓内脏带等脑区,而在大脑白质及小脑中无明显的密集分布区。

Objective To construct spinocerebellar ataxia 3 (SCA3) eukarotic expression vector with en hanced green fluorescent protein as report gene and to observe its expression in PC12 cells.

目的 构建以增强型绿色荧光蛋白作为报告基因、带有脊髓小脑性共济失调3型(SCA3)基因的真核细胞表达载体,并转染PC12细胞,观察外源基因的表达情况。

Results The clinical manifestations of TOBS comprised transient unconsciousness, vertigo, dyskinesia of eyeball, abnormality of pupils, dyskinesia of limbs, hemianopsia or cortical blindness, ataxia and memory impairment. MRI showed the local infarction in thalami, cerebellum, midbrain, pons, occipital lobe, temporal inner surface. The features of DSA were occlusion or stenosis in basilar artery and vertebral artery.

结果 TOBS的临床主要表现为一过性意识障碍、眩晕、眼球运动障碍及瞳孔的变化、肢体运动障碍、偏盲或皮质盲、共济失调及记忆功能损害;磁共振显示梗死灶在丘脑、小脑、中脑、脑桥、枕叶、颞叶内侧面;数字减影血管造影显示为基底动脉及椎动脉闭塞或狭窄。

The apopostic cells can be found in the cerebellum at very early phase after theinsults in the animal HIBD model of neonatal rabbit, and the second is in the cortex,the third is in the area of hippocamp.

论文二: 1。在新生兔HIBD模型中,患侧小脑细胞凋亡较早发生,其次为大脑和海马,缺氧缺血后时间随时间推移凋亡细胞数明显增多。

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