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The brain capillary and star glue quality cell which enwrap around it under thenormal condition form the permeation extremely low blood-brain barrier, onlypermit some little molecule to pass; When cerebral isc.

正常状态下的脑毛细血管及包裹在其周围的星形胶质细胞构成了通透性极低的血脑屏障,只允许一些小分子物质通过;当缺血性中风发生时,微血管通透性发生显著改变,这种病理变化与脑内皮细胞损伤导致的功能变化有直接的关联。

The tumor is lobulated under microscope, some immature Sertoli cells were arranged as either amorphous plaques, funicular, broad beam, nest, solid or hollow tubules; Leydig cells existed individually or in clusters, and their cytoplasm was abundant and eosinophilic.

镜下肿瘤呈分叶状,有不成熟的支持细胞排列呈片块状、不规则形或条索状、宽梁状、巢状、实性或空心的小管;莱迪细胞呈单个或簇集存在,细胞浆丰富且嗜酸。

IL-1 is elevated in tissue homogenates of temporal lobe and in cerebrospinal fluid from patients with AD. In Alzheimer patients activated immunoreactive IL-1+microglia are increased sixfold over those presenting in age matched controls and the activated IL-1+ microglia are involved in the evolution of diffuse plaque to the diagnostic neuritic plaque. IL-1 is produced by astrocytes and microglia which are components of senile plaques and induced astroglia proliferation.

AD患者颞叶脑组织及脑脊液中发现IL-1含量增高,并且IL-1免疫反应阳性的小胶质细胞比同龄的对照组高6倍,IL-1免疫反应阳性的小胶质细胞与弥散性淀粉样沉淀斑块发展成为具有诊断意义的神经纤维斑块有关。

Microglia, one of the main immune cells in central nerve system, was activated in inflammation with morphological changes from resting ramified to staffed and amoeboid cells.

作为脑内的主要免疫细胞,小胶质细胞在中枢神经系统炎症过程中被过度激活,表达或释放细胞因子和炎症介质,是早老性痴呆发生发展的重要因素。

Cases healthy subjects served as control. In addition, density of glomerular matrix membrane and quantity of cell in glomeruli were measured with CMIAS image analysis system by computer. Global sclerosis, cellular crescents, fiber or fibrocellular crescents were measured with Memphis scope. Tubulointerstitial lesions were examined with semi-quantitative grades (including O-III grades).Results Compared to normal control, there was a significant increase of urinary TGF-betaK IL-6 and Col-lV levels in patients with IgAN (p. 01). There were also significantly positive correlation between the levels of urinary TGF-betaK Col-IV and density of glomerular matrix membrane ., interstitial fibrosisp.

采用酶联免疫吸附法测定尿TGF-β1(Transforming growth factor-β1)、尿IL-6(interleukin-6)和尿Col-Ⅳ(type Ⅳ Collagen);采用免疫组织化学法检测肾组织TGF-β1、Col-Ⅳ表达;应用CMIAS多功能真彩色病理图像分析系统对肾小球基质基底膜面密度和细胞个数进行半定量测定;对球性硬化、节段硬化、细胞新月体及纤维或纤维细胞新月体所占肾小球百分数和肾小球IgA沉积免疫荧光强弱的判断采用Memphis法进行评分;肾小管间质病变程度采用光镜下半定量分级法(包括0-Ⅲ级)。

What was observed under a light microscope included: tumor cells were mulberry and micropapillary shaped or were of glandule tubular arrangement; there was obvious interspace between cancer nest and neighboring areas; micropapillary was empty of fiber blood vessel axes, with micropapillae floating freely in spongy spaces and separated by fibrous septa.

光镜下特征性表现为肿瘤细胞呈桑椹状、微乳头状或小腺管样排列,癌巢与周围间质形成明显的空隙,微乳头缺乏纤维血管轴心,每个微乳头细胞团和周边的纤维组织均存在无细胞的间隙样结构;瘤细胞CerbB-2、CgA和EMA。

The large granulocytes show characteristics of holocrine, and the small hyalinocytes are a transient type of residual cell bodies of large granulocytes after the holocrine process finished.

大颗粒细胞还具有全质分泌的特性,小透明细胞极可能是大颗粒细胞全质分泌后的一时性残余胞体。

The histopathology showed that the tumors were rich in cells arranged in fascicles with bipolar and spindled processes. The nuclei showed minor pleomorphism. A few tumor cells were centered on the vessels with a nuclear-free zone that was characteristic of ependymoma.

病理组织学上肿瘤富于细胞,排列成束状、交织状,细胞胞突细长双极,核异型性小,少数肿瘤细胞围绕血管周围形成室管膜瘤的无核区结构。

Under low temperature condition, fertility restoring, anther developing normally, the tetrads formed after archesporical cell, sporogenous cells and microspore mother cell. Subsequently, microspores were free from the tetrad of fertile anther and formed mature pollen grains, tapetumof the fertile anthers began to disintegrate and disappear at last.

在低温处理条件下,育性恢复,花药发育正常,经过孢原细胞期、造孢细胞期、花粉母细胞期后,可以顺利形成四分体,可育花药的四分体可以释放出小孢子并发育为成熟的花粉粒,同时绒毡层细胞开始解体,最后消失。

Results Group C had the symptoms such as reduced activity, acceded, indulge in lying and weight loss after 3 weeks of immune injection, 14 out of 16 SD rats in Group B had the same symptoms as Group C after 4~5 weeks of immune injection, the serum enzymes in model groups increased significantly compared with those of the control group, model group C was much higher than model group B; the duration shorted, amplitude decreased, multiphase wave increased in electromyogram of model groups; MRI examination revealed samples from model group B and C had one positive case each, which presented T1MI isodensity or hypodensity signal, T2MI and STIR serial hyperdensity signal, revealing muscle inflammation; all rats'skeletal muscle from model group C and 11 out of model group B had pathological changes, which exhibited striated muscle focal fiber degeneration, necrotized and inflammatory cell infiltration, interstitial vessel wall thickening, random cardiac muscle samples had 3 positive changes, which had similar changes to skeletal muscle, there was 1 positive change from lung sample.

结果:模型C组于免疫注射第3周左右开始出现活动减少,倦怠嗜卧,食欲体重下降等表现,模型B组有14只SD大鼠于免疫注射第4~5周出现上述症状,较C组为轻;模型组肌酶谱中,肌酸激酶、乳酸脱氢酶、谷草转氨酶与对照组比较明显升高,模型C组较模型B组升高更显著;模型组肌电图时限缩短,波幅降低,多相波增多;磁共振检查模型B组和C组选送标本中各有一例有阳性改变,表现为T1MI等或稍低信号,T2MI及STIR序列为高信号,提示肌肉炎症水肿改变;模型B组有11只,模型C组全部大鼠骨骼肌出现病理改变,表现为横纹肌局灶性分布的肌纤维变性炎细胞浸润,间质小血管壁增厚、扩张,随机选送的心肌标本中有3例有阳性改变,表现与骨骼肌相仿,选送的肺标本中有1例有阳性改变,表现为蛋白渗出,炎症细胞浸润和小血管改变。

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