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Under optical microscope, the cell of NS arrayed as nest, the nuclear was big, deep-stained, thickened-karyotheca, chromatin granulated, Pathologic karyokinesis can be seen.

DDP组癌巢周围可见少量纤维组织增生、局灶性坏死,并可见炎细胞浸润;LNT组镜下见少量细胞凋亡,凋亡细胞变小,变圆,核固缩,胞浆浓缩,染色加深,凋亡细胞周围未见炎症反应;LNT+DDP组与LNT组镜下大体相同,但可见到较多量的凋亡细胞。

Each group with drug had effect on inhibiting Lewis lung cancer tumor,LNT DDP had the best effect,46.2%,the rate of inhibitory effect of LNT、DDP was 35.6%、39.7%respectively.3.Under optical microscope,the cell of NS arrayed as nest,the nuclear was big,deep-stained,thickened-karyotheca,chromatin granulated,Pathologic karyokinesis can be seen.

DDP组癌巢周围可见少量纤维组织增生、局灶性坏死,并可见炎细胞浸润;LNT组镜下见少量细胞凋亡,凋亡细胞变小,变圆,核固缩,胞浆浓缩,染色加深,凋亡细胞周围未见炎症反应;LNT DDP组与LNT组镜下大体相同,但可见到较多量的凋亡细胞。

The differentiation states of costae indicates the ways they absorb and transport water, and their ability adapting to the dry conditions, which was elucidated by the following examples: Brachythecium plumosum, because of its thin cell-walls in the costae and the absence of hydrome, assistant and steroid cells, can absorb water and nutrition under shady and moist conditions; Plagiomnium rostratum, though often grows in shady and wet condition, has hydrome and steroid cells, a feature similar to those of xeric mosses, which endows it to grow in the conditions with periodical drought stress during its life cycle; Hygrohypnum luridum is characterized by its slender leaves with only one layer of cells, the thin cell-walls, the absence of filaments on the leaf surface, and the fewer layer cells in the costae, the absence of hydrome and steroid cells. These features make it adaptable to aquatic environments. For Pogonatum inflexum and Atrichum undulatum, their ventral surfaces covered with lamella, while for Racomitrium japonicum, Thuidium cymbifolium, Macromitrium ferriei, Diphyscium fulvifolium, Barbula unguiculata and Ceratodon purpureus, their leaves are strongly mammillose or papillos. Such appendiculate structures made them adaptable to thy conditions.

例如,荫湿生环境下的羽枝青藓Brachythecium plumosum,其中肋细胞胞壁较薄,无导水主细胞和副细胞的分化,也没有厚壁细胞分化,能够在阴湿环境下吸收水分和养分;钝叶匍灯藓Plagiomnium rostratum具有与旱生藓类植物相似的中肋结构,叶片较厚,中肋具导水主细胞,中肋背面具厚壁细胞,这些特点使该种藓类植物能够分布于间隙性干旱胁迫的环境中;水灰藓Hygrohypnum luridum叶片纤细柔弱,仅1层细胞,细胞胞壁薄,叶表无附属结构,中肋细胞层数少,无导水主细胞分化,也没有厚壁细胞,这些特点使得水灰藓'能够生长在水生环境中;东亚小金发藓Pogonatum inflerum和波叶仙鹤藓Atrichum undulatum的叶腹面覆盖着栉片,东亚砂藓Racomitrium japonicum、大羽藓Thuidium cymbifolium、福氏蓑藓Macromitrium ferriei、东亚短颈藓Diphyscium fuhifolium、扭口藓Barbula unguiculata和角齿藓Ceratodon purpureus的叶片表面有乳头状突起或疣状物,这些附属结构使它们能够适应于旱生的环境中。

The results showed that the contents of glutamic-pyruvic transaminase and glutamic oxaloacetic transaminase in part of the dogs were high and spontaneous pathologic changes occurred in the important organs, such as lung, kidney and brain. The incidences of interstitial pneumonia, cerebral ependymitis and vascular infiltration were high. Cloudy swelling and vasular degeneration appeared in part of hepatocytes and epithelial cells of renal tubules.

实验结果为部分犬的肝功能谷丙转氨酶和谷草转氨酶偏高;肝、肺、肾和大脑等重要脏器有自发性病理改变;肺的间质性肺炎和大脑室管膜炎及血管围管性浸润发生率较高,部分肝细胞和肾小管上皮细胞呈现浊肿或空泡变等。

Of them 25 cases of oral cancer (G1-2) were randomly divided into trail and control group . The remained 11 cases of nasopharyngeal and maxillary sinus cancer (NPC-MSC, mainly G3-4) were attributed to a third group (1st course: sBRM, then 2nd course: IAC). The order of drug-use of sBRM is: pre-immunomodulation of the reactivity of patient low-dose CTX and PolyI∶C, then in- juring tumor and thereby modulation of its immunogeneity (DDP-PYM regimen , thereafter, reaction enhancement modu- lation [low-dose rhuIL-2, Cimetidine and Indomethacin ] . All drugs, except for CTX, PolyI∶C and Indo, were fractionally delivered in a manner of continously infution in 8-10 hours via a retaining intra-external carotid artery catheter CAVAFIX 335 SPLITTOCAN G14, B.

将其中25例晚期口腔高、中分化鳞癌病人随机分为实验治疗(12例)和对照治疗(13例)两组,实验组采用sBRM疗法,具体用药为:先用小剂量环磷酰胺和聚肌胞对机体反应性作预调变,然后用低剂量DDP-PYM化疗杀伤&致创&癌细胞,使其免疫原性增强并借之诱导肿瘤浸润淋巴细胞,化疗结束后续用小剂量rhuIL-2激活和扩增TIL,特别是其中的T细胞,并借助小剂量西咪替丁、消炎痛调节机体以原发灶为中心的癌受创相关反应。

Result 1 Magnetic nanoparticles, magnetic nanoparticles modified with antisense oligodeoxynucleotide of human telomerase reverse transcriptase induced HL-60 tumor cells to apoptosis, we could see typical morphologic change of apoptosis cells: karyopyknosis, chromation"s condensing and aggregation in nuclear, forming crescent-shaped or annulus structures to lean on edge of cell nucleus"s membrane and posing apoptosis body by Atomic Force Microscope, Fluorescence microscope, transmission electron Microscope 2 There was a significant difference compared with control group(p.01), inhibition ratio had significant positive correlation with medication dosage and time ;during 0.8-8μM dosage amplitude, inhibition ratio accrescenced by dosages increasing. However, the inhibition ratio would decrease when dosage over 8-80μM.

结果 1 磁性纳米粒子、修饰有端粒酶反义寡核苷酸的磁性纳米粒子诱导HL-60细胞发生凋亡,原子力显微镜、光学显微镜、荧光显微镜和透射电镜下均观察到HL-60细胞呈现典型的凋亡细胞的形态变化:细胞核固缩,核内染色质浓缩、凝聚、形成新月形或环状结构紧靠在细胞核膜边缘,并形成凋亡小体。2 磁性纳米粒子、修饰有端粒酶反义寡聚脱氧核苷酸的磁性纳米粒子对HL-60肿瘤细胞的生长和增殖有明显的抑制作用,与对照组相比有显著性差异(p<0.01),在剂量为0.8-8μmol/L范围内,抑制率随剂量的增加而增加,当剂量超过8μmol/L时,抑制率反而下降;3 磁性纳米粒子、修饰有端粒酶反义寡聚脱氧核苷酸的磁性纳米粒子可增强p53基因的表达活性,引起DNA降解损伤,反向调节细胞周期活动,促使细胞从G0期进入G1期,抑制肿瘤细胞的生长。4 修饰有端粒酶反义寡聚脱氧核苷酸的量子点能通过内吞作用进入HL-60肿瘤细胞的细胞核,可以在细胞内进行定位和促进HL-60肿瘤细胞的凋亡。

Hepatocyte growth factor/scatter factor is a multifunctional cytokine with mitogenic, motogenic, and morphogenic activities for renal tubular cells.

肝细胞生长因子是一个对肾小管上皮细胞具有强烈丝裂原活性以及细胞运动与形态调节的多效性细胞因子。

Results No apparent cytopathic effects could be observed during the first 24 hours of infection with L-form and elementary bodies, but the cytoplasm of some MA104 cells became vacuolated when the L-forms entering into the cells as shown by immunohistochemical staining and PCR.

结果 发现金葡菌L型及滤过的原生小体对细胞致病性降低,细胞不出现明显病变,部分细胞出现空泡样变,免疫组化及金葡菌PCR显示感染细胞内出现金葡菌抗原及DNA。

In experiment 4, Schwann cells were seeded on PDLLA-T3 with the density of 2×106cells/ml, the foams were sterilized by infrared and removed air from the pore to facilitate the infiltration of cell suspension.

实验三,观察材料对培养雪旺细胞的影响,在雪旺细胞培养皿内加入小块甲状腺激素人工神经材料,发现该材料能使雪旺细胞数增加,刺激雪旺细胞分泌更多的NGF,提高雪旺细胞的活性,提示该材料对雪旺细胞有正性促进作用。

The characteristics of typical pattern of MF infection are nodular granulomas or diffuse inflammation with mixed granulomas which con-sisted of central abscesses surrounded by epithelioid and giant cells,abundant vacuole zosters or ring structures(lipid-like struc-tures) around the necrotic lesions and small granulomatous nodules.

结节性或弥漫性炎症伴混合性肉芽肿(中央为脓肿围绕着上皮样细胞及巨细胞)以及坏死灶及肉芽肿样小结节周围出现大量空泡细胞条带或环状结构为偶发分枝杆菌感染的最典型表现形式。

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