小细胞性的

The theory is cell kinetics and mechanism of drugs.

主要是根据细胞动力学原理和药物的作用机理分析，如果把药物集中应用，一方面只是一过性的杀灭增殖期的白血病细胞，对静止期细胞影响不大，另一方面对正常细胞造成较大损伤，而如果药物作用于几个细胞增殖周期，对白血病细胞进行几个循环的打击，会清除更多白血病细胞，而对正常细胞损伤较小。

To date,it has been documented after transfusion of unirradiated blood components to at least 87 patients:in patients with severe combined immunodeficiency,thymic hypoplasia,and Wiskott Aldrich syndrome premature newborns and those with erythroblastosis fetalis; patients with hematologic malignancies including Hodgkin\'s and non-Hodgkin\'s lymphomas,acute myelocytic and lymphoblastic leukemias,chronic lymphocytic leukemia,and aplastic patients with solid tumors including neuroblastomas, glioblastoma,rhabdomyosarcoma,cervical carcinoma,small cell lung cancer,and germ cell tumor;patients after cardiac surgery and cholecystectomp-60;and in an apparently healthy 22-year-old woman.

目前为止，输注未辐照血液成分后，至少引起了87例TA-GVHD的发生，主要见于以下病人：严重的免疫缺陷病人、胸腺发育不全、Wiskott Aldrich综合症、早产儿、胎儿红细胞增多症、何杰金与非何杰金氏淋巴瘤等恶性血液病人、急性粒细胞性和淋巴细胞性白血病、慢性淋巴细胞性白血病、成神经细胞瘤等实体瘤病人、横纹肌赘瘤、宫劲癌、小细胞肺癌、微细胞瘤、心脏和胆囊手术病人。

To produce the scientific evidence for developing and manufacturing new antitumor drugs.Methods: 1 The inhibitory effect on cell growth of Hela was measured by MTT assay in treated or untreated groups (3.125, 6.25, 12.5, 25, 50μg/ml TAM and control) for three different treatment times (24h, 48h and 72h).2 Apoptosis and cell cycle were measured by FCM in four experimental groups (0, 4, 16, 40μg/ml TAM) for 48h.3 Adopting Wright and Giemse's staining to observe the morphology of Hela cells which treated with 40μg/ml TAM.4 Using invasion experiment to detect the Hela cells'invasive abilities which treated with 40μg/ml TAM.5 The protein expressional levels of P-ERK, ERK, C-myc and Cyclin D1 in Hela cells untreated or treated with 4, 16, 40μg/ml TAM for 24h were measured by Western blot.6 Expression of anti-apoptotic gene bcl-2, apoptotic gene bax and MMP-9 in Hela cells of four experimental groups (0, 4, 16, 40μg/ml TAM for 24h), were observed by revers transcription PCR.7 The protein expression of P-ERK, ERK, Bcl-2 and Bax in Hela cells treated with 40μg/ml TAM for 24h observed by laser scanning microscopes.

1采用四甲基偶氮唑蓝法检测不同浓度北豆根总碱(3.125、6.25、12.5、25、50μg/ml)处理不同时间(24、48和72小时)对Hela细胞增殖反应的抑制作用。2采用流式细胞技术(flow cytometry，FCM)检测不同浓度北豆根总碱(0、4、16、40μg/ml)作用48小时，对Hela细胞凋亡及周期变化的影响。3瑞氏-姬姆萨染色后显微镜观察北豆根总碱(0、40μg/ml)作用24小时后Hela细胞形态学变化。4采用Transwell小室法检测北豆根总碱(0、40μg/ml)作用24小时后对Hela细胞侵袭性的影响。5采用免疫印迹方法检测不同浓度北豆根总碱(0、4、16、40μg/ml)作用24小时后，Hela细胞中磷酸化ERK、ERK、C-myc、CyclinD1的表达变化。6采用逆转录-聚合酶链反应(revers transcription PCR，RT-PCR)半定量检测北豆根总碱(0、4、16、40μg/ml)作用24小时，Hela细胞抗凋亡基因bcl-2、促凋亡基因bax、基质金属蛋白酶-9(MMP-9)的表达变化。7应用激光共聚焦显微镜(laser scanning microscope，LSM)观察北豆根总碱(0、40μg/ml)作用24小时后，Hela细胞内P-ERK、ERK、Bcl-2、Bax蛋白的表达变化。

METHODS: A series of N-octyl-N'-succinyl chitosan labeled with fluorescein, were incubated with HepG2 liver cancer cells, K562 leukemia cells, A549 human lung cancer cells, and BGC cancer cells respectively and followed by using flow cytometry and enzyme-linked immunosorbent assay to assess the affinity and inhibition of N-octyl-N'-succinyl chitosan for the four kinds of tumor cells already mentioned.

用异硫氰酸荧光素对N-正辛基－N'-琥珀酰基壳聚糖进行标记，再分别与人肝癌细胞(HepG2)、人白血病细胞(K562)、人非小细胞肺癌细胞(A549)及人胃癌细胞共培养，通过流式细胞仪及酶联免疫检测仪测定N-正辛基－N'-琥珀酰基壳聚糖对肿瘤细胞的亲和性及抑制力。

A portion of ductal cells and individual serous acinic cells of the minor salivary gland also expressed Fas not only in membranous but also in cytoplasmic pattern.

结果发现，在正常鼻咽粘膜表面及隐窝的假复层纤毛柱状上皮细胞胞膜、部分小涎腺的导管上皮和个别浆液性腺泡上皮细胞的胞膜和胞浆Fas阳性表达；鳞状化生上皮的表层细胞胞膜有Fas表达，但基底细胞未见Fas表达；浸润的淋巴细胞也不表达Fas.45.9%（17/37）的鼻咽非角化性癌Fas阳性，但只有不足10%的癌细胞胞膜微弱表达Fas。

Of 92 acutely dissociated dorsal root ganglion cells recorded by current patch-clamp technique, 34% were discharged by FA application with the mean onset latencies of the first action potential being (367.34+/-32.96) s. All the FA-sensitive cells were identified as nociceptor cells by their distinguishable features of AP including longer duration, existence of a hump on the repolarizing phase, and longer after-hyperpolarization of APs.

运用电流钳记录的92个背根神经节细胞中，大约有34%的中、小细胞对甲醛溶液敏感，产生动作电位的发放，其产生动作电位的潜伏期是(367.34±32.96) s，并且单个动作电位复极化相具有伤害性感受器细胞的特征性，如动作电位间期较长、复极化相有&驼峰&以及较长的后超极化相。

More materil as took from resected specimen is helpful for finding more small cell carcinoma,there is poor prognosis in small cell carcinoma concomitant with squamous cell carcinoma compared with squamous cell carcinoma alone,it is suggested that primary small cell carcinoma of esophagus might be derived from a totipotentiality primitive cell in the basal region of the squamous mucosa of the esophagus.

对手术切除标本足够取材有利于发现肿瘤的异源性成分；小细胞癌合并鳞癌者，预后较单纯鳞癌者差；本文结果支持食管小细胞癌起源于原始多潜能干细胞的观点。

In an attempt to evaluate the safety and efficacy of Healon in trabeculectomy, 20 eyes with Healon and 20 eyes without Healon injection after trabeculectomy are compared. Trabeculectomy using Healon will not induce transient rise of intraocular pressure. By filling the anterior chamber with Healon, a tamponing effect results which will maintain a deep chamber and reduce complications such as flat anterior chamber, choroidal detachment and striate keratopathy in the early postoperative period. In long-term evaluation there is no difference in pressure control, conjunctival scarring and corneal endothelial cell loss between Healon group and Non-Healon group.关键词 trabeculectomy , flat anterior chamber , choroidal detachment , intraocular pressure

为了评估Healen在小梁切除术中之疗效及安全性，选20位接受小梁切除术者，同时注射Healon於前房为实验对象，另20位接受传统小梁切除术为对照组，发现使用Healon并不会引起一过性眼压上升的现象，Healon注入前房，产生填塞作用，最大的好处是可以维持前房深度，减少术后合并症如前房消失，脉络膜剥离及角膜水肿等，然长期追踪，对於降眼压的幅度，不因使用Healon而可达到低眼压状态，也不会减少结合膜瘢痕化而促进房水引流，然Healon系一无毒，无炎性，无抗原性高黏稠性的物质，不因使用而发生炎性反应，同时有保护角膜内层细胞的功能。

The marrow between the pink bone trabeculae seen here is nearly 100% cellular, and it consists of leukemic cells of acute lymphocytic leukemia that have virtually replaced or suppressed normal hematopoiesis .

如图可见粉红色的骨小梁之间的骨髓几乎100%是细胞，是由急性淋巴母细胞性白血病的白血病细胞构成，这些细胞实际上替代或抑制了正常的造血作用。

The aim of our study was to determine the amount and composition of immune cells within glomeruli and peritubular capillaries in cellular and humoral allograft rejection.

我们研究的目的在于明确在细胞性排斥和体液性排斥时肾小球和肾小管周围毛细血管免疫细胞的沉积情况。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新