小纤维间的

Diabetic nephropathy is one of the common serious microvascular complications of diabetes mellitus,as a result of the feature between glomerular mesangial membrane proliferation and interrenal fibrosis for extracelluar matrix excessive accumulation in the kidney. Many patient with DM are predisposed to developing diabetic nephropathy and die from it.

糖尿病肾病是以细胞外基质在肾脏的过度聚集导致肾小球系膜增生和肾小管间质纤维化为特征的严重微血管并发症，是糖尿病致残因素和重要的死亡原因之一。

AbstractDiabetic nephropathy is one of the common serious microvascular complications of diabetes mellitus,as a result of the feature between glomerular mesangial membrane proliferation and interrenal fibrosis for extracelluar matrix excessive accumulation in the kidney. Many patient with DM are predisposed to developing diabetic nephropathy and die from it.

糖尿病肾病是以细胞外基质在肾脏的过度聚集导致肾小球系膜增生和肾小管间质纤维化为特征的严重微血管并发症，是糖尿病致残因素和重要的死亡原因之一。

Results In the medium and high dose F0 groups, it was observed that the atrophy and incrassation of seminiferous tubule, decrease of spermatogenesis, hyperplasia of interstitial tissue, especially in high dose groups spermatozoon abnormality and nucleolus concentration in the rats testis after DU ingestion for 14 months. The changes became more severe with the prolongation of DU ingestion. Such changes occurred in filial rats (F1) after DC ingestion for 5 months. In the medium and high dose F0 groups, it was observed that a little atrophy of kidney glomerulus, hyperplasia of interstitial tissue after DC ingestion for 14 months, and kidney glomerulus fibrosis happened after DC ingestion for 20 months, such changes occurred in filial rats (F1) after DC ingestion for 5 months In the medium and high dose F0 groups, splenic germinal center and periarterial lymphatic sheaths were hyperplasia , companies with lymphopoiesis after DC ingestion for 7 months, splenic white pulp became more small and sparse after DC ingestion for 20 months.

结果 F0代的中、高剂量组大鼠摄入贫铀14个月后可见雄性的精曲小管萎缩，管壁增厚呈空虚网状，生精细胞层次减少，间质细胞增生，但仍见有精子生成；高剂量组可见到精子呈异型性改变，细胞核浓缩深染，且随着摄入时间延长改变愈趋明显；F1代大鼠摄入贫铀5个月后就有上述改变且更为严重。F0代中、高剂量组大鼠摄入贫铀14个月后肾小球轻度萎缩，间质增生明显，20个月时肾小球萎缩纤维化；F1代大鼠摄入贫铀5个月后就有上述改变。F0代中、高剂量组摄入贫铀7个月时脾脏生发中心和淋巴鞘增生，淋巴母细胞增生活跃，20个月时脾小体减少，生发中心稀疏；F1代大鼠摄入贫铀早期和晚期有类似改变。F0和F1代高剂量组摄入贫铀早期肝脏有炎症细胞浸润，晚期骨髓有核细胞减少，脂肪细胞增加。

Resujts:① The distribution of lesions are mostly symmetrical, extensive, predominant in the middle and lower lung fields, and posterior areas in peripheral;② There are so many HRCT findings of lung, ILD is predominant: intralobular interstitial thickening 46 cases (100%), ground-glass opacity 41 cases (89.13%), peribronchovascular or centrilobular interstitial thickening 40 cases (86.96%), interlobular septal thickening 38 cases (82.61%), irregular linear opacity 37 cases (80.43%), small nodular opacity 34 cases (73.91%), subpleural line 27 cases (58.70%), bmnchiectasis or bronchiolectasis 19 cases (41.30%), patch opacity 18 cases (39.13%), expiratory mosaic sign 15 cases (32.61%), interface sign 14 cases (30.43%), honeycombing 12 cases (26.09%), emphysema or bulla 3 cases, cystic airspace suspected 1 case, and atelectasis suspected 1 case;③ Mediastinum and pleura: multiple small lymphonodi in mediastinum 41 cases (89.13%), pleural thickening or rough 38 cases (82.61%), esophagoectasis 11 cases (23.91%), unilateral little pleural fluid 1 case, and mediastinal emphysema 1 case.

结果：①皮肌炎肺部病变分布呈对称、广泛、偏中下、偏外后的特点；②肺部HRCT表现多样，以肺间质性改变为主：小叶内间质增厚46例(100%)，磨玻璃影41例(89.13%)，支气管血管束增宽或小叶核心增大40例(86.96%)，小叶间隔增厚38例(82.61%)，不规则纤维索条影37例(80.43%)，结节影34例(73.91%)，胸膜下线27例(58.70%)，支气管或细支气管扩张19例(41.30%)，斑片影18例(39.13%)，呼气相马赛克征15例(32.61%)，界面征14例(30.43%)，蜂窝影12例(26.09%)，肺气肿或肺大泡3例，单纯囊状气腔1例，肺不张l例；③纵隔及胸膜：纵隔小淋巴结影41例(89.13%)，胸膜增厚或毛糙38例(82.61%)，食管扩张11例(23.91%)，单侧少量性胸腔积液1例，纵隔气肿1例。

Intrarenal CRP level but not serum CRP is closely associated with TIF in chronic CsA nephrotoxicity.

结论］ 慢性CsA肾毒性肾小管间质纤维化与肾内CRP的表达水平密切相关，与血清CRP的含量无关。

RESULTS The degenerative changes of nerve ending in Meissner's corpuscles were observed after 1 month of denervation, and the basic structure of the corpuscles had no obvious changes. After 3 months, the axons of corpuscles were disappeared, and the volume of corpuscles was shrunk. The basic structure of nerves was disappeared, and the lemmocyte and neurolemma plate were changed after 5 months.

结果 失神经1个月时触觉小体内的神经末梢已有溃变，触觉小体的基本结构无明显改变；3个月时轴突消失，触觉小体的体积开始萎缩；5个月时神经结构消失，膜细胞及其膜板亦开始改变；8个月时触觉小体内胶原纤维含量逐渐增多；12个月时触觉小体内膜结构与膜间基质完全消失，被胶原纤维代替。

Protophase empirical study confirmed that SLT can treat nephritis model of immunity and mesenterium hyperplasy, and can obviously lighten interstitial fibrosis of nephric tubule induced by Adriamycin.

前期实验研究证实，SLT 对大鼠免疫性系膜增生性肾炎模型有治疗作用，能明显减轻阿霉素所诱导的肾小管间质纤维化。

Results Incubation of TEC with MAC increased the expression of collagen type Ⅳ(P.05) in comparison with unstimulated cell.Conclusion MAC can i...

结论亚溶破剂量的MAC能使HKC的Ⅳ型胶原表达上调，可能是引起肾小管间质纤维化细胞外基质增多的原因之一。

ResuIt:1. JDD can significantly improve the digestive system symptoms and physical strength of CRF patients. It can also reduce the urine protein.plasma lipids,BUN and Scr notably.The total effective rate of treatment group is 86.67%,better than that of control group(P.05).2.The experiment revealed JDD can restrain the crescendo-developed mechanism of CRF,which is achieved by decreasing blood ET-1,plasma lipids,urine protein etc.lt also can lighten glomerular sclerosis,inhabit uriniferous tubule-interstitial fibrosis.

结果：1。降氮汤能明显改善消化道症状及体力等一般情况，显著降低尿蛋白，血脂和血Scr、BUN，其总有效率86.67％，显著优于尿毒清对照组(P＜0.05)。2，实验发现降氮汤可通过降低血ET-1、血脂、尿蛋白等途径抑制CRF的渐进性发展机制，减轻肾小球硬化和肾小管-间质纤维化，具有肾保护作用。

The histopathologic changes included lymphocyte and monocyte infiltration,hyperplasia of synovial cells and small vessels,interstitial fibrosis,hyaline degeneration and cartilaginous metaplasia.The immunohistochemical observations showed that the high expressions of IL-1 and IL-6 were significantly different between the pathologic plicae and the control groups（P＜0.01）.The positive expressions of IL-1 and IL-6 were the synovial cells and monocyt-lymph cells in the pathologic synovial plicae.The positive expressions of MMP-1 and TIMP-1 have significant difference between the experiment and control group（P＜0.01,P＜0.05）.The expression of MMP-1 was positive in synovial lining cell,monocyte,fibroblast,endothelial cell in small vessel and chondrocyte.The TIMP-1 expression was detected in the synovial lining cells and a small quantity fibroblast.

结果 正常滑膜皱襞和病理性滑膜皱襞在滑膜细胞增生及小血管增生、间质纤维化及玻璃样变、软骨化生组织学改变方面，差异均有显著性（P＜0.01）；IL-1、IL-6在病理性滑膜皱襞内的增生滑膜细胞、单核及淋巴细胞和在正常滑膜皱襞内的表达差异均有显著性（P＜0.01）； MMP-1、TIMP-1在病理性滑膜皱襞和正常皱襞内的阳性表达，差异具有显著性（P＜0.01，P＜0.05），MMP-1在增生滑膜衬里层细胞、单核和纤维母细胞、血管内皮细胞和软骨化生的软骨细胞呈阳性表达；TIMP-1只在滑膜衬里层细胞和少量纤维母细胞有表达。

Plunder melds and run with this jewel!

掠夺melds和运行与此宝石！

My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻，也许正是在通往天国的路上，我体验着这白色的晕旋。