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Objective To investigate whether mesenchymal stem cells can promote the recovery of acute renal tubular damage induced by mercuric chloride and to explore its possible mechanism.

目的 观察骨髓间质干细胞对氯化汞(HgCl2)导致的急性肾小管损伤有无治疗作用,并探讨其可能的机制。

Methods Primary metanephric mesenchyme stem cells were cultivated and multi-directional differentiation was induced.

方法原代分离培养后肾间充质干细胞,在体外特定诱导条件下观察细胞向成骨细胞、脂肪细胞及肾小管上皮细胞的分化及其形态演变,采用细胞免疫荧光检测细胞表面特定蛋白的表达变化。

Pineal intercellular canaliculus-perivascular space-epithelial openings made up the structural foundation of the chief channel for secretions of pineal body releasing into CSF.

细胞间小管-血管周隙-囊上皮孔,构成了松果体分泌物释放入脑脊液主渠道的结构基础。

At high magnification, many neutrophils are seen in the tubules and interstitium in a case of acute pyelonephritis .

高倍镜下,急性肾盂肾炎的病例中在肾小管和肾间质区可以看到有大量的中性粒细胞浸润。

Straw smashing device sectionally set front of sower resolved the problems that long straw gathered on the opener and the sower could not pass. A sectional feeder-beater assembled before smashing made the straw fed into the smashing smoothly. The parameters of configuration and movement of working parts was properly designed and the position was properly arranged made the power consumption...

该机将秸秆粉碎装置分段布置在播种机构前方,较好地解决了长秸秆聚集使开沟管挂草壅堵的问题;在秸秆粉碎装置前设置喂入轮使喂入顺畅;合理设计了各工作部件的结构参数和运动参数,合理配置了部件间的相对位置;整机功耗小,各项性能指标达到有关标准的要求。

Objective: To observe the mutual adsorption of hydroxyapatite particles and the sealing effect Of HA microparticles on dentinal tubules.

目的:观察羟磷灰石同质间的吸附和羟磷灰石微粒子对牙本质小管的封闭效果。

Results: The expression of CTGF protein and CTGF mRNA in the nomal and sham operation group is low in the intracytoplasm of Mesangial cells, renaltubular epithelial cells and renal interstitial cells. Compare with sham operation group, the expression of CTGF protein and CTGF mRNA as yellow particulate in the mode group was markedly increased, and the fibrosis of nephridial tissue is obvious. Panaxnotoginseng could significantly decrease the expression of CTGF protein and CTGF mRNA(P.05), and there was no significant difference between Panaxnotoginseng treatment group and Benazepril treatment group.

结果:正常组及假手术组肾小球系膜细胞、肾小管上皮细胞以及肾间质细胞胞浆内有少量CTGF蛋白及其mRNA的黄色颗粒状阳性反应物,模型组上述部位的CTGF蛋白及其mRNA呈强阳性表达,三七总皂苷组上述指标表达较模型组显著减少,有统计学差异(P.05),与阳性药物组比较差异不显著。

Simvastatin may suppress interstitial fibrosis by effect CTGF、suppress cell proliferation、redue extracellular matrix accumulation.

辛伐他汀可以抑制CTGF、抑制肾小管上皮细胞的转分化、减轻细胞外基质的积聚,从而减轻间质纤维化,发挥肾保护作用。

At high magnification, many neutrophils are seen in the tubules and interstitium in a case of acute pyelonephritis.

高倍镜下,见急性肾盂肾炎的肾小管和肾间质中有中性粒细胞。

Our study showed that EGFprotein was mainly localized in the cell plasma of distal tubules and Henle'sloops and EGF mRNA was distributed not only in the nucleuses of above sitesbut also in a few nucleuses of interstitial cells and glomerulus cells.

本研究表明EGF蛋白主要位于髓袢和远曲小管细胞胞浆,而EGFmRNA除了位于上述部位的细胞核中外,在少数间质细胞、肾小球细胞细胞核内也有少量表达。

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