小管间的

Diabetic nephropathy is one of the common serious microvascular complications of diabetes mellitus,as a result of the feature between glomerular mesangial membrane proliferation and interrenal fibrosis for extracelluar matrix excessive accumulation in the kidney. Many patient with DM are predisposed to developing diabetic nephropathy and die from it.

糖尿病肾病是以细胞外基质在肾脏的过度聚集导致肾小球系膜增生和肾小管间质纤维化为特征的严重微血管并发症，是糖尿病致残因素和重要的死亡原因之一。

AbstractDiabetic nephropathy is one of the common serious microvascular complications of diabetes mellitus,as a result of the feature between glomerular mesangial membrane proliferation and interrenal fibrosis for extracelluar matrix excessive accumulation in the kidney. Many patient with DM are predisposed to developing diabetic nephropathy and die from it.

糖尿病肾病是以细胞外基质在肾脏的过度聚集导致肾小球系膜增生和肾小管间质纤维化为特征的严重微血管并发症，是糖尿病致残因素和重要的死亡原因之一。

We also have observed some organs pathological changes of juvenile Jian Carp, such as pancreas acinous gland and zymogen granules of acinous gland cell disappearing, intercellular substance hyperplasia and inflammatory cells soakage, hepatatrophia, liver cell granular or vacuolar degeneration and necrosis, karyolysis or pyknosis, glycogen granules decreasing, metanephros atrophy, metanephric canaliculus epithelium granular or vacuolar degeneration and necrosis, mitochondrion swelling and mitochondrion cristae disappearing, karyolysis, distal convolutal tubule microvilli desquamating, spleen marrow cell degeneration and necrosis, intercellular substance of spleen hyperplasia, spleen atresia, blood corpuscle disappearing.

后肾土黄色、淡褐色或苍白色，肾小管上皮细胞肿胀、颗粒或水泡变性、坏死，细胞内有大量血细胞流出，线粒体肿胀，嵴结构消失，细胞核溶解，肾间质甲状腺滤泡和拟淋巴细胞增生，远曲小管微绒毛脱落、管道细胞界限不清。心脏肌纤维肿胀、颗粒或空泡变性，严重的肌纤维溶解、变细或断裂，肌纤维间水肿、炎性细胞浸润，部分心肌细胞核浓缩。脾脏暗褐色，脾髓质细胞变性、坏死，拟淋巴细胞明显减少，淋巴细胞岛少见、岛中细胞成份减少，黑素巨噬细胞中心减少、体积缩小，脾脏网状基质水肿，脾窦闭锁，血细胞减少。

Results In the medium and high dose F0 groups, it was observed that the atrophy and incrassation of seminiferous tubule, decrease of spermatogenesis, hyperplasia of interstitial tissue, especially in high dose groups spermatozoon abnormality and nucleolus concentration in the rats testis after DU ingestion for 14 months. The changes became more severe with the prolongation of DU ingestion. Such changes occurred in filial rats (F1) after DC ingestion for 5 months. In the medium and high dose F0 groups, it was observed that a little atrophy of kidney glomerulus, hyperplasia of interstitial tissue after DC ingestion for 14 months, and kidney glomerulus fibrosis happened after DC ingestion for 20 months, such changes occurred in filial rats (F1) after DC ingestion for 5 months In the medium and high dose F0 groups, splenic germinal center and periarterial lymphatic sheaths were hyperplasia , companies with lymphopoiesis after DC ingestion for 7 months, splenic white pulp became more small and sparse after DC ingestion for 20 months.

结果 F0代的中、高剂量组大鼠摄入贫铀14个月后可见雄性的精曲小管萎缩，管壁增厚呈空虚网状，生精细胞层次减少，间质细胞增生，但仍见有精子生成；高剂量组可见到精子呈异型性改变，细胞核浓缩深染，且随着摄入时间延长改变愈趋明显；F1代大鼠摄入贫铀5个月后就有上述改变且更为严重。F0代中、高剂量组大鼠摄入贫铀14个月后肾小球轻度萎缩，间质增生明显，20个月时肾小球萎缩纤维化；F1代大鼠摄入贫铀5个月后就有上述改变。F0代中、高剂量组摄入贫铀7个月时脾脏生发中心和淋巴鞘增生，淋巴母细胞增生活跃，20个月时脾小体减少，生发中心稀疏；F1代大鼠摄入贫铀早期和晚期有类似改变。F0和F1代高剂量组摄入贫铀早期肝脏有炎症细胞浸润，晚期骨髓有核细胞减少，脂肪细胞增加。

Mix to kidney spherule respectively the qualitative pathology change degree between kidney canaliculus undertakes half ration gives a mark, immune group is changed detect the expression of Pax2 and WT1, expression of analytic kidney Pax2, WT1 and nephritic pathology integral and its are both the relation between.

分别对肾小球和肾小管间质的病理改变程度进行半定量评分，免疫组化检测Pax2和WT1的表达，分析肾脏Pax2、WT1表达和肾脏病理积分及其两者之间的关系。

CD44 and osteopontin were produced by intrinsic glomerular and tubular epithelial cells, and may play an important role in pathogenesis of rat experimental crescentic glomerulonephritis.

在实验性新月体肾炎模型，CD44和OPN在肾小球实质细胞和小管间质细胞显著表达，并可能在新月体肾炎的发病过程中发挥重要的作用。

Intrarenal CRP level but not serum CRP is closely associated with TIF in chronic CsA nephrotoxicity.

结论］ 慢性CsA肾毒性肾小管间质纤维化与肾内CRP的表达水平密切相关，与血清CRP的含量无关。

Objective: To observe the expression of bone morphogenic protein-7 (BMP-7) in the kidney of rats with unilateral ureteral obstruction, and to explore the relationship between BMP-7 and renal tubulointerstitial lesion.

目的：观察单侧输尿管梗阻大鼠模型中骨形态发生蛋白7（BMP-7）在肾组织中的表达部位，动态变化及其与肾小管间质损害的关系。

Results Incubation of TEC with MAC increased the expression of collagen type Ⅳ(P.05) in comparison with unstimulated cell.Conclusion MAC can i...

结论亚溶破剂量的MAC能使HKC的Ⅳ型胶原表达上调，可能是引起肾小管间质纤维化细胞外基质增多的原因之一。

Objective To study the relationship between the persistent nephrotic syndrome and damage of tubulointerstitium in children.

目的 探讨儿童难治性肾病和小管间质损害之间的关系，更好地指导临床治疗，判断预后。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。