小的环

Tetrahydroisowuinolin derivatives and phthalide derivatives were designed and synthesized on the basis of a PDE4 inhibitor pharmacophore model set up through computer simulation. Some tetrahydroisowuinolin derivatives synthesized were evaluated on their activity against PDE4 for study on the structure-activity relationship.(7-cyclopentyloxy)-6-methoxy-3,4-dihydroisoquinolin-2(1H)-yl(4-hydroxy-3-methoxyphenyl)methanone (155) and Methyl 7--6-methoxy-2-(4-methoxy- benzoyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (170) showed good activity against PDE4, which were chosen as the lead compounds to design and synthesize another analogs in order to develop selective PDE4 inhibitors with better activity.

分别设计合成了以四氢异喹啉和氨基苯酞为骨架的两类小分子杂环化合物，并对部分四氢异喹啉衍生物测试了其相关的生物活性，初步确定了其构效关系，发现了两个对PDE4有较好抑制活性的先导化合物(7-cyclopentyloxy)-6-methoxy-3，4-dihydroisoquinolin-2(1H)-yl(4-hydroxy-3-methoxyphenyl)methanone (155)和Methyl 7--6-methoxy-2-(4-methoxy- benzoyl)-1-phenyl-1，2，3，4-tetrahydroisoquinoline-3-carboxylate (170)。

Base on the result, a new antiarrhymic drug model was established, and the molecular mechanism was clarified why matrine and berbamine were not so effective on arrhythmia compared to amiodarone and RP58866. The antiarrhythmic mechanism of Chinese traditional drugs cyclovirobuxine D and water extracts from codyceps sinensis was investigated, and a scheme was produced to potentize the afficacy of antiarrhythmic Chinese traditional drugs.

在此基础上，建立了一种新的抗心律失常药物模型，阐明苦参碱和小檗胺抗心律失常作用弱于胺碘酮和RP58866的分子机制；并探讨了中药环维黄杨星D、冬虫夏草水提液抗心律失常作用机制，提出了增强抗心律失常中药效能的方案。

On the view of the result of experiment, the motor started stably and quickly with small toque pulsant and had wide scope of speed adjustment. It can content all of the request of the compressor of refrigeratory.

本控制系统是针对冰箱压缩机电机研制的，从试验的测试结果来看，电机起动稳定快速、转矩脉动小，具有较宽的闭环调速范围，完全满足冰箱压缩机电机各项性能指标要求。

Friendly, Peter Saraf, Albert Berger, Ron Yerxa --"The buzz got out that it was actually good," says "Little Miss Sunshine" producer Marc Turtletaub of the weeks preceding Sundance 2006, when the long-gestating project suddenly became Utah's hottest commodity.

阳光'反复酝酿作出驳回-环奖：生产者与两次国际：博turtletaub，大卫汤匙友彼得的Saraf阿尔贝伯杰夏Akin--&动感传出的确是好&，&小阳光小姐&的监制马克turtletaub星期前森丹斯2006年当长期孕育项目陡然犹他州的热门商品。

It was ciliary body edema, ciliary body detachment, choroids detachment, subchoroid hemorrhage and following changes of trabecular meshwork that was the principal mechanism of secondary glaucoma after SEO.

睫状体水肿、脱离、脉络膜脱离、由此继发的前房和小梁网的改变是兔眼巩膜环扎术后继发性青光眼的主要机制。

In addition, the four-armed macrocyclic guest forms a complex with molecular cage, in which each of the limbs of the guest protrudes from a unique macrocyclic face of the host to result in a turtlelike supramolecular complex.

我们亦成功地合成具有四突出取代基的小环分子并以之与笼状冠醚分子错合形成独特的类&乌龟&形的超分子错合体。

And the temperature susceptibility of the vulcanized-SBR asphalts were reduced to a great extent, their properties were improved apparently from low to high temperature, their application would be developed widely in the high temperature environment conditions.

硫化共混改性沥青对使用环垅的温度敏感性变小，使改性沥青的高低稳定性能均得到改善，可在高温环境下使用，拓宽了SBR改性沥青的使用范围。

Floe size affects routing decisions: small floes of thick ice can be circumnavigated, while larger floes must be transited.

浮冰则影响了路径的选择。厚冰中的小浮冰可以环航而过，而较大的浮冰则必须横过。

Number of polymorphic bands changed after irradiation. Flawing bands and increasing bands were observed in amplified bands of 14 selected ISSR primers.

双环蘑菇变异最大，200和500Gy辐照引起的ISSR变异率分别为33.3%和50.5%；金针菇变异最小，200、500和800Gy下的ISSR变异率分别为2.3%、2.3%和3.1%，杏鲍菇菌丝的变异率分别为8.6%、13.4%和20.0%。

The biggest problem with breaking your engine in on the street is if you ride the bike on the freeway (too little throttle = not enough pressure on the rings) or if you get stuck in slow city traffic.

磨合发动机最大的问题是如果你行驶在高速上（小油门等于没有足够的压力施加到环上）或在交通拥堵的城市里。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。