小核

Based on the theory of isomorphic mapping and singular value decomposition theorem, the maximum of the kernel Fisher discrimination criterion can be skillfully acquired by solving the minimum of its reciprocal in a small space, and the final solution is acquired without taking account of the null space and non-null space of the kernel within-class scatter matrices separately.

基于同构映射原理和奇异值分解定理，在一个更小的空间内将核Fisher描述准则函数的极大值问题转化为其倒数的极小值问题，使最终的解不需要分开考虑核类内散度矩阵的零空间和非零空间。

In resting cysts, the microtubules under the pellicle, cortical ciliatures, conjunctions between cilia basal bodies, supporting structure of basal bodies and other microtubule structures are absorbed in different extent; microtubule-like assemble bodies appear at the center of the remained cilia basal bodies; the granules of chromatin and nucleolus in macronucleus become smaller whereas nucleus pores of the micronucleus become bigger; the inner membrane of some nucleus pores are attached with chromatin.

结果表明：纤毛虫形成包囊过程中，皮层细胞质中产生具有自噬泡消化特征的细胞器，将部分纤毛结构等逐步消化；休眠包囊中，表膜下微管、皮层纤毛器和纤毛基体间连接、基体托架及其他微管结构不同程度地被吸收、在残剩纤毛基体的中央形成微管形结构聚合体，大核染色质和核仁颗粒变小，核孔增大，并发生染色质附着于核孔内膜的现象；细胞脱包囊期间，皮层细胞骨架、线粒体等经历了在残剩结构基础上的再分化。

On basis of study on the regulation of nucleator and nano-CaCO3 on small batch bulk PP, we put great emphasis on the discussion of the relation between two kinds of modification procedures.

在研究纳米改性和传统的β成核剂改性规律的基础上，重点探讨了两类改性方法之间的联系和协同改性作用。在小本体PP／β成核剂二元体系的研究中，主要比较了两种不同的小本体045、075的结晶性能和力学性能。

More than 30 kinds of meshfree methods are reviewed in this paper in the light of weighted residual method, and different meshfree methods can be viewed as different forms of weighted residual method and/or with different approximation functions. Various kinds of meshfree approximate schemes are presented in detail, including moving least square approximation, kernel and reproducing kernel approximation, partition of unity approximation, radial basis approximation, radial point interpolation and natural neighbor interpolation.

详尽介绍了各种无网格近似方案(包括移动最小二乘近似、核近似和重构核近似、单位分解近似、径向基函数近似、点插值近似、自然邻接点插值近似等)和无网格法中常用的各类加权余量法(伽辽金格式、配点格式、局部弱形式、加权最小二乘格式和边界积分格式等)，并讨论了数值积分方法和边界条件的处理等问题。

Along the length of the uncoiled chromosomes are beadlike structures called nucleosomes, highly organized aggregations of DNA and histones.

解聚后的染色体呈现一系列核小体相互连接的串珠状结构，核小体是由 DNA 和组蛋白高度有序的结合形成的。

Light microscope and transmission electron microscopy showed that SMMC-7721 cells induced by SAHA had undergone the restorational alteration in morphology and ultrastructure, which were different from those of nontreated cells but were similar to those of normal cells, and the changes were as follows: the cells turned to be flat and spread; the nucleo-cytoplasmic ratio lessened and nuclear shape became rather regular; the number of nucleolus reduced and its volume lessened; euchromatin increased while heterochromatin decreased in nucleus; in the cytoplasm, mitochondria grew in number with relatively consistent structure and well-developed mitochondria cristae; Golgi complex turned to be well-developed and typical; rough endoplasmic reticulum increased. Immunocytochemistry assay showed that the expression of AFP and PCNA were declined significantly. FCM analysis showed SAHA could arrest SMMC-7721 cells in G0/G1 phase, with an accumulation of the cells in G0/G1 phase while a decrease of cells in S phase. Semi-quantitative RT-PCR detection revealed that the expression of p21WAFl mRNA was upregulated remarkably in the cells treated with SAHA.

结果：倒置显微镜和透射电镜观察显示，经SAHA处理的细胞增殖速度显著减慢，细胞体积增大，细胞核较小，形状较为规则，核仁数量减少、体积变小，核内常染色质增多而异染色质减少，核质比例减小，细胞质内线粒体数量增多、线粒体嵴发达，高尔基体较为典型，粗糙型内质网增多，呈现出与正常上皮细胞相似的形态变化；MTT比色法测定结果显示不同浓度(2.5、5.0、7.5、10.0uM)SAHA对SMMC-7721细胞的增殖均有抑制作用，并有明显的剂量依赖和时间依赖关系；免疫细胞化学检测显示SAHA能显著降低PCNA和AFP在SMMC-7721细胞中的表达；流式细胞仪检测结果显示，SMMC-7721细胞经SAHA处理后，G0/G1期细胞明显增加，S期细胞则明显减少，细胞被阻滞于G0/G1期；RT-PCR检测结果表明，SAHA作用12h后SMMC-7721细胞中p21WAF1 mRNA的表达即有增加，24h后更为明显。

The histone octamer may protect the wrapped DNA from interacting with other environmental factors such as transcription regulating proteins, thus the positioning of nucleosomes along DNA may play important roles in multiple cellular processes including DNA replication, transcription and damage-repair.

由于核小体结构中的DNA缠绕在组蛋白八聚体上，可能影响这些DNA与细胞内的其他蛋白相互作用，从而影响到DNA复制、转录等生物学过程，因此，核小体在基因组上的位置分布可能对基因组功能具有重要的调控作用。

Some exudation and bleedings happen in the pulmonary alveoli, some inflammatory cells infiltrate into lung tissues; in the serum AMY, ALP, TNF-α, IL-6 increases obviously high, COX-2 expression increase; The expression of NF-κB in big rat lung of SAP increase, and the nucleus is thick dyed, it explain that the NF-κ moved into the nucleus; Stimulate the inflamatory reaction.

我们的实验中见到SAP组的大鼠肺脏组织细胞腔扩大、肺泡壁断裂，有的出现肺大泡，肺泡内伴有渗出及少量非出血，肺组织可见咽细胞浸润；血清中AMY、ALP、TNF-α、IL-6明显增高；在SAP组大鼠肝细胞、肾小管上皮细胞、肺脏小气管及肺泡上皮上COX-2表达增加；NF-κB在SAP大鼠肺脏中表达增加，并且出现核浓染，说明NF-κB前移入核；启动炎症反应等一系列反应SAP大鼠受损伤的肺组织中AQP-1无论在mRNA水平上、蛋白水平上还是免疫组化染色病理学检测上都明显下降。

When chromatin is reproduced, a stretch of DNA already associated with nucleosomes is replicated, giving rise to two daughter duplexes.

体外合成核小体要从考虑自由DNA和组蛋白的组装过程开始，但体内的核小体仅在DNA复制时形成。

Histones play a major architectural role, holding the coiled DNA in supercoils or beads, about 10nm in diameter and consisting of about 170base pairs.

组蛋白与 DNA 非特异性的结合，包装成为核小体，核小体彼此连接形成直径约10nm 的串珠结构，包含170个碱基对。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。