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In nonclinical studies, normal cells appear to beable to recover from intermittent proteasome inhibition, but many types of cancercells undergo apoptosis when proteasomes are inhibited, even for a short time.

它可以选择性地抑制蛋白酶小体的苏氨酸蛋白酶活性,减少对特定细胞周期调节蛋白(IkB、p53、p27、p21等)的降解。由于这些调节蛋白的集聚,肿瘤细胞分裂周期受到干扰,细胞分裂停止,最终导致细胞凋亡。

Methods A total of 60 male rats were randomly assigned into normal group,model group,drug control group,low -dose(17.5 mg·kg-1),mid-dose (35.0 mg·kg-1) and high -dose QLS (70.0 mg·kg-1) groups,10 rats in each group. White cell count,lecithin corpuscle density in prostatic fluid,prostate weight and prostate index were observed respectively after acute rat models were made by injecting 1 % carrageenan in th e seminal vesicle of prostate gland notopodium.

Wistar大鼠按体重区组随机分组方法分为空白对照组、模型组、阳性对照组及QLS低(17.5 mg·kg-1)、中(35.0 mg·kg-1)、高剂量组(70.0 mg·kg-1),每组10只,分别于前列腺背叶的精囊腺注入1 %角叉菜胶生理盐水溶液,制作大鼠非细菌性前列腺炎模型,观察测定前列腺液中白细胞数和卵磷脂小体密度、前列腺重量、前列腺指数。

In addition, it must also evade immune clearance. Elimination of H. pylori by phagocytes is inefficient because H. pylori exhibits several virulence factors to evade opsonization, retard phagocytosis, and disrupt membrane trafficking and phagosome maturation after internalization of the microorganism.

为了增加存活与持续的依附在宿主体内,幽门螺旋杆菌发展出一些策略来抵御被免疫清除的命运,它可影响吞噬细胞的功能,包括避免受调理作用、抑制吞噬细胞的吞噬作用、影响细胞内的运输作用与吞噬小体的成熟。

No pacinian corpuscles were found.

未发现环层小体的再生。

Antoni type A areas consist of compact spindle-shaped cells with twisted nuclei and indistinct cytoplasmic borders. They are arranged in interlacing fascicles with nuclear palisading, whirling, and Verocay bodies.

Antoni A型区的细胞呈梭形,胞核扭曲,胞质边界模糊,细胞排列为呈束状交错或旋涡状,胞核呈栅栏状,有Verocay小体

The results were as follows: Compared with control group, the weight and the relative weight of thymuses, bursas of Fabricius and spleens of experiment group increased significantly(P<0.05) or extremely significantly(P<0.01). In experiment group, the cortex of thymic lobule, bursa nodule and Periarterial Lymphatic Sheaths thicken obviously; the volume of bursa nodule, splenic nodule and ellipsoid augmented, and the germinal center of splenic nodule were obvious; the thymic corpuscle increased; the plica of bursas of Fabricius developed well and the degenerating of it retarded.

结果表明:试验组鸡胸腺、腔上囊、脾的重量和器官指数均高于对照组,差异显著(P<0.05)或极显著(P<0.01);试验组的胸腺小叶皮质增厚,胸腺小体增多;腔上囊皱襞发达,腔上囊小结体积大,皮质较厚,退化延缓;脾的动脉周围淋巴鞘增厚,脾小结体积大,生发中心明显,椭球增大。

Pulmonary hemorrhage and pneumonedema are the significant pathological traits of pulmonary injury in blast injury.

肺出血、水肿是冲击伤肺损伤重要的病理特点,伤后肺泡Ⅱ型上皮细胞变形,板层小体减少。

Transmission electron microscope results revealed vascular endothelial cells with normal morphology in the control group and tumor cells with apparent nucleoli in the Ad-GFP group, while in the Ad-aMMP-2 group, some vascular endothelial cells exhibited chromatin pycnosis in the nucleus, forming apoptotic bodies.

透射电镜观察对组血管内皮细胞形态正常;Ad-GFP组瘤细胞大,核仁明显;Ad-aMMP-2组部分血管内皮细胞核内染色质固缩,聚积成团块状形成凋亡小体

Results: Of all the semen samples, 8 were HCMV positive, 4 HSV-Ⅱ positive, but none were both HCMV and HSV-Ⅱ positive. HCMV late antigens were positively and HCMV early antigens negatively expressed in the spermatogenic cells of the 8 HCMV positive cases. In the 4 HSV-Ⅱ positive cases, 3 were positively and 1 weakly positively expressed. In the semen of the 12 positive cases were found large numbers of immature spermatogenic cells, with different manifestations of apoptosis, such as chromatin pycnosis, vacuoles, damaged nuclear membrane, and apoptotic bodies, but without virus infection-induced specific morphological alteration.

结果:83例精液样本PCR检测HCMV阳性8例,HSV-Ⅱ阳性4例,未发现2种病毒同时阳性病例。8例HCMV阳性病例ICC标记生精细胞HCMV晚期抗原均见阳性表达,HCMV早期抗原均为阴性表达;4例HSV-Ⅱ阳性病例ICC标记生精细胞3例阳性表达,1例弱阳性。12例病毒阳性病例均发现较多未成熟生精细胞,并有不同程度的核染色质固缩、出现空泡、核膜破损、核崩解、凋亡小体等凋亡现象,但未能找到病毒感染的特异性形态学改变。

RESULTS On HE staining, acinar cells in the pancreas showed pyknotic nuclei and formation of apoptotic bodies, which is the typical morphological features of apoptosis.

结果 HE染色观察到胰腺组织中典型的细胞凋亡形态学特征:细胞核固缩及凋亡小体形成。

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Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气,收缩臀部肌肉;拱起身体,尽量抬起头来,右腿伸直朝向天花板(膝微屈,以避免肌肉紧张)。

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However, to get a true quote, you will need to provide detailed personal and financial information.

然而,要让一个真正的引用,你需要提供详细的个人和财务信息。