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导致分裂

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Due to the deficiency of cyclin B1 and 〓, spermatogonia and pachytene/diplotene primary spermatocytes in contralateral cryptorchid testis were unable to form MPF, and therefore, they could not accomplish their nuclear division, and became arrested at the transition stage from mitosis to meiosis (G2/M phase). We also found that testosterone could regulate the cyclin B1 expression in spermatogenic cells.

由于cyclin B1和〓的缺失,粗线期/双线期初级精母细胞中的MPF无望形成,从而导致生精细胞分裂停滞在由有丝分裂向减数分裂过渡的G2/M相;(5)睾酮可在翻译水平上调控阴囊内睾丸生精细胞cyclin B1蛋白的表达。

To investigate whether the expression of cdc2 and cyclin B1 in spermatogenic cells during spermatogenesis is actually a temperature dependent event, in situ hybridization, Western blotting and immunohistochemistry analysis were used to study the expression of cdc2 and cyclin B1 in normal and cryptorchid testis. Results showed that heat would differentially hurt male germ cells in different developmental stages during spermatogenesis, especially the pachytene primary spermatocytes. Most of spermatogonia in contralateral cryptorchid testis were not harmed fatally by heat as yet, indicating that spermatogonia could resist to beat to a certain extent. In this case spermatogonia could develop to pachytene/diplotene primary spermatocytes, but they could not acquire the ability to complete the transition from mitosis to meiosis, and then appeared to go through apoptosis. Therefore, we could not find the descendants of meiosis: secondary spermatocytes and round spermatids, elongated spermatids and spermatozoon. The abdominal temperature had no significant influence on the transcription of cdc2 and cyclin B1 in the spermatogonia and pachytene/diplotene primary spermatocytes. In normal rabbit testis, cyclin B1 increased in the pachytene/diplotene primary spermatocytes before meiosis and reached its peak in the spermatids.

为了解精子正常发生过程中cdc2和cyclin B1表达的低温依赖性,我们利用原位杂交和免疫组化等方法,研究了正常和隐睾精子发生过程中cdc2和cyclin B1的转录和翻译调控活动,结果表明:(1)热对各阶段的雄性生殖细胞都有损害,粗线期的初级精母细胞尤为敏感,实验性隐睾内的精原细胞尚未完全受到"致命"影响,说明精原细胞对热有一定的耐受性,但即使成为粗线期/双线期初级精母细胞,却未能获得由有丝分裂过渡到减数分裂的能力,呈现不同程度的凋亡,所以在整个切片中找不到源自减数分裂的产物----次级精母细胞、圆形精子细胞,更谈不上长形精子细胞和精子的形成;(2)腹腔高温未明显地影响隐睾精原细胞和粗线期/双线期初级精母细胞中cyclinB1和cdc2的转录,说明高温并不是通过影响cyclin B1和cdc2的转录活动而导致生精过程阻断的;(3)正常兔睾丸组织中,〓在精原细胞和粗线期/双线期精母细胞中均有表达:cyclin B1蛋白在减数分裂前期的粗线期/双线期初级精母细胞中的表达量增加,于变态末期的精子细胞中达高峰。

This is the very divisive process of thought.

这正是思想导致分裂的过程。

Comparison and measurement are ways of the intellect. This is divisive.

比较和衡量是智力运作的方式,这会导致分裂

The separation from the imperial church of the bishops who led the Nestorian schism and the capture of Antioch in 637 by the rising power of Islam checked the further distinctive development of the School of Antioch.

分离从帝国教堂的主教谁导致分裂和景教捕获637安提阿的日益强大的伊斯兰检查了独特的发展进一步学院的安提阿。

In conversation, many Chinese seem to fear that democratisation could lead to separatism and civil war.

在谈话中,很多中国人似乎担心民主化可能导致分裂与内战。

Article8 In the event that the"Taiwan independence" secessionist forces should act under any name or by any means to cause the fact of Taiwan's secession from China, or that major incidents entailing Taiwan's secession from China should occur, or that possibilities for a peaceful reunification should be completely exhousted, the state shall employ non-peaceful means and jother necessary measures to protect aChina's soverignty and terriotrial intergrity.

第八条 "台独"分裂势力以任何名义、任何方式造成台湾从中国分裂出去的事实,或者发生将会导致台湾从中国分裂出去的重大事变,或者和平统一的可能性完全丧失,国家得采取非和平方式及其他必要措施,捍卫祖国主权和领土完整。

"And this is because injustice creates divisions and hatreds and fighting, and justice imparts harmony and friendship; is not that true, Thrasymachus?"

"难道是因为非正义能导致分裂、仇恨和战争,而正义能赋予和谐与友爱吗;我说的对不对,斯拉斯马科斯?"

This can result in a splitting ofwavelength-dependent loss band and make the codirectional mode coupling condition (of the fundamental core mode into cladding modes) be different at two principal input polarizations.In a PM-LPG fabricated with a PMF having relatively small birefringence , the adjacent resonant dips (slow-axis and fast-axis resonant dips) resulting from the two principal input polarizations have identical cladding mode order and the wavelength separation between them is several nanometers

这可能导致分裂的ofwavelength-dependent损失,使codirectional乐队的耦合条件(模式基本核心人才培养模式为层模式)是不同的两种主要的输入波在PM-LPG捏造和具体情况有相对较小的双折射,相邻的谐振(slow-axis和fast-axis引起共振蘸)的两种主要模式有相同的输入波的波长层顺序和他们之间的分离是几奈米的图案

A single intermolecular recombination event between two circles generates a dimeric circle; further recombination can generate higher multimeric

在两个循环间的一个单细胞间重组产生了一个二体循环,进一步的重组能产生更高级的多体形式,这将导致分裂单元数的减少。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

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