对映体

It is well known that P450 enzymes in mammals represent products of a supergene family, but the majority of compounds are metabolized by three different P450 families.

现在认为大多数药物是由P450 Ⅰ、Ⅱ、Ⅲ三个家族代谢的。clau对映体的羟化代谢反应是由哪一个家族的亚酶代谢的呢？

Calix[4]arene is investigated most widely due to its stable conformation and easy derivatization. Among them lots of works reported the chiral calix[4]arenes can be used in enantiomeric recognition and dectection.

杯[4]芳烃因其稳定的构象和易于修饰的特点，成为研究最为广泛的杯芳烃分子，其中大量的文献报道了能够用于对映体识别和检测的手性杯[4]芳烃。

As a result,it is of vital importance to separate the enantiomers of a chiral drug in metabolic studies.

因此，在手性药物代谢的研究中，同时测定对映体是极为重要的。

The effects of cholic acid concentration and pH of the buffer on separation were studied, and the influences of organic additives such as methanol, acetonitrile, isopropyl alcohol were also examined.

该实验表明电化学检测同样可用于手性物质的分离，从而扩宽了电化学检测的应用范围，并为对映体的定量合成和纯度测定找到了灵敏的检测方法。

Studing on samarium diiodide promoted asymmetric intramolecular reducing coupling reactions, we have made the resolution of the racemic biaryl dials by using enantiomeric N-tert-butanesulfinamine as the resolving reagent successfully and thus obtained a series of axially chiral biaryl dials with high enantiomeric excess.

中文摘要在二碘化钐促进的分子内不对称还原偶联反应中，我们不仅对联芳基二醛底物的合成路线进行了优化，还发现N-叔丁基亚磺酰胺辅基可以作为手性试剂，成功地对联芳基骨架二醛化合物进行拆分，得到高对映体过量的轴手性二醛类化合物。

It was also noted that lipases preferentially esterify the S-isomer of ibuprofen, thus the scheme for resolution of ibuprofen in organic solvent can be expressed as follows

实验中发现脂肪酶优先酯化布洛芬S-对映体，因此在有机相中用脂肪酶催化酯化拆分布洛芬的方案可表示如下

Both three-dimensional chiral compounds have intriguing chiral channels, which are built up of homochiral intertwined double helices. The circular dichroism spectra of 1 and 2 in water have shown they are stable in solution, which document they will be significantly useful in asymmetric catalysis and chiral medicine.

以Keggin结构多金属氧酸盐为建筑单元，通过手性的铜-脯氨酸配合物作为模板剂构筑了2个基于Keggin结构多金属氧酸盐的3D纯手性化合物，化合物1和2是一对对映体，代表了世界上第一例3D手性多酸化合物，具有由同手性螺旋缠绕形成的手性孔道，水溶液中的圆二色谱表征这个3D手性化合物可稳定存在，显示这个物种可以在不对称催化及手性药物方面有潜在的巨大的应用价值。

Xinquan HuTwo new chiral backbones R-- and S--2-amino-2"-hydroxy-4,4",6,6"-tetra methyl-1,1"-biphenyl were synthesized via nitration, diazotation/iodination, Ulhnann coupling, selective reduction, diazotation/hydrolysis, hydrogenation and resolution from 2,4-dimethyl-aniline in seven steps.

以2，4-二甲基苯胺为起始原料，经过硝化反应、重氮化碘代反应、Ullmann缩合反应、选择性双硝基单还原反应、重氮化水解反应、催化氢化反应和拆分，首次合成了--2-氨基-2'-羟基-4，4'，6，6'-四甲基-1，1'-联苯和--2-氨基-2'-羟基-4，4'，6，6'-四甲基-1，1'-联苯两个对映体。

The selection of developing chiral drug s as strategy is on the important basis of chiral pharmacology study results but it is necessar.

基础生物化学研究推动手性药物市场持续增长，2 0 0 1年单一对映体药物市场为 14 70亿美元，占世界药品市场 4 10 0亿美元的 36 %。

New chiral phosphonic acids and zirconium phosphonates might have potential applications in asymmetric synthesis, enantioseparation and biochemistry.

手性有机膦酸及新手性层状膦酸-磷酸锆在不对称合成、对映体拆分和生物化学都可能有潜在的应用。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。