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However it was shown its eventually inhibiting effect on apoptotic myocyte cells during I〓 R〓h (P＜0.05); The PKC inhibitors chelerythrine and scutellarein have no effect on expression of Fas protein, whereas they can significantly upregulate the expression of Bcl-2 protein.

4PKC激活剂PMA可下调Fas基因的蛋白表达，对Bcl-2蛋白的表达也有抑制作用，它对缺血30min、再灌注24h后心肌凋亡细胞的最终影响为抑制效应(P＜0.05)，而PKC抑制剂CHE、灯盏花素对Fas基因蛋白表达无明显干预影响，但对Bcl-2蛋白表达呈显著上调作用，故对心肌细胞凋亡的抑制作用更为明显(P＜0.01)。

Under a fixed model of chromospheric flare, we investigate the influences of Hα and CaIIK line profilles on various velocity distributions from semiempirical view. The results show that: Hα line is very sensitive to the velocity in upper chromosphere; the profile of CaIIK line have responses to velocity in any layer of chromosphere, but the degree of CaIIK line asymmetry is much weaker than that of Hα and can be ignored if velocity is as small as 10km/s; chromospheric condensation in lower part of transition region have strong influence on Hα line but contrary to CaIIK line, the typical characteristic of H line effected by chromospheric condensation in transition region is reversed blue asymmetry, i.e. the intensity of blue peak is stronger than that of red peak; the stronger the chromosphoric condensation is, the more obvious the Hα line asymmetry appears; and so on.

在确定的大气模型下，从半经验角度系统地研究了大气各个层次的速度场和运动结构对Hα和CaⅡK谱线轮廓的影响，得到；Hα线对色球上部速度场敏感，而对色球下部和温度极小区附近速度场不敏感；CaⅡK对整个色球速度场均有反应，但不对称性较Hα弱，且速度小于10km/s时不对称性很不明显；CaⅡK受过渡区色球凝聚的影响较弱，而Hα对色球凝聚十分敏感；色球凝聚影响Hα轮廓的典型特征是呈反转结构的兰不对称性，即兰峰强于红峰；色球凝聚越强，Hα不对称性也越显著：等。

The baseline-sensitivity of Cladosporium fulvum to azoxystrobin was established,the present resistance situation of C.fulvum in different areas to Azoxystrobin was studied,and the resistant risk of C.fulvum to azoxystrobin was also assessed in laboratory.Resistance mechanism of C.fulvum to azoxystrobin was studied preliminarily.The results are shown as follows.

本试验建立了番茄叶霉病菌对嘧菌酯的敏感性基线：研究了目前不同地区的番茄叶霉病菌对嘧菌酯的抗药性现状；进行了番茄叶霉病菌对嘧菌酯的室内抗药性风险评估；对番茄叶霉病菌对嘧菌酯的抗性与苯丙氨酸解氨酶的活性进行了初步探讨，获得了如下研究结果： 1。

On the basis of previously research, this paper re-probe into the mechanism of electro-chemist mechanical manufacturing process, making the rational technological parameter, and developing the manufacturing equipment. Through a lot of technology tests, get a lot of labratory data, accordingly, researched the surface feature of the electro-chemist manufacturing process, and deeply discussed its influence on the work piece feature. The last result is that: the electro-chemist mechanical manufacturing process can reduce the low-frequency component significantly, but on high-frequency component, it has little influence, having obviously positive pole flat effect. After manufacture, the tip parts on the surface of the work piece is cut off, there is micro "high land" shape, the parameter for surface roughness is reduced a lot, the surface outline of the work piece is negative, the bearing length rate is cliffy. Also the surface quality of the work piece is improved. This can help to avoid changing the shape, improve the feature of rub, gear and reduce the time to suit. This would also ensure the precision and result in a longer work piece life.

在以前研究的基础上，本论文重新探讨了电化学机械复合光整加工工艺的机理，确定了较合理的工艺参数，对电化学机械复合光整加工设备进行了改进，通过工艺实验广泛地搜集了大量实验数据，依据实验数据，多角度地研究了电化学机械复合光整加工的表面形貌特点，并且从理论上深入讨论了电化学机械复合光整加工表面形貌对工件工作性能的影响，最后得出的结论为：电化学机械复合光整加工对工件原始表面的低频成分有较大程度的降低，而对高频成分影响较小，有明显的阳极整平作用，被加工工件表面的尖峰状凸起被去除，工件表面呈现出微观&高原型&，表面轮廓不平度高度特性参数大幅度降低，工件表面轮廓分布集中，且呈负偏态，轮廓偏斜度为负值，轮廓支承长度率曲线陡峭，工件的表面质量得到综合改善，这对提高零件的抗接触变形能力、改善摩擦、磨损性能、降低工件的磨合时间、提高工件的精度保持性、延长工件的寿命均有利。

Another conclusion is that stability is better in accretion bank than in colluvial deposit bank.A comprehensive study has been made on the course of reservoir bank recession on the theory of fluvial and wave dynamic mechanics with a view of character of mountain land. Some appraise and rectifying suggestions for current methods are given by computing the scale of the bank recession in the area.

通过对河流水动力条件、水库波动动力学等几个方面并结合山区水库特点对水库岸坡的塌岸过程进行了系统的研究，并运用不同的方法对水库蓄水后的岸坡塌岸宽度进行了预测，从预测结果对不同的方法进行了评价，并对现有的方法和结果提出了修改建议。

The study showed the recombinant wt/mCREG protein depressed the VSMC proliferation depending on dose and the optimal concentration was 400nM;2biologic function of CREG protein and the membrance receptor mechanism:①effect on VSMC migration: the wound healing experiment showed the OB2 cells migration was slower significantly after added wt/mCREG(400Nm) in supernatant. The HITASY cells migration were very slowly and no remarkable change. The gelatinase digestion and Western blot analysis showed the matrix metalloproteinase was decreased and TIMPs was increased;②effect on differentiation: after added wt/mCREG(400nM), the expression of myocardin, SMα-actin, MHC and caldesmin were increased and that of LM-1 and FN were decreased in OB2 cells. These effects were more significant when adding wtCREG.;③effect on VSMC proliferation: Cell cycle assay and BrDU stain showed: after added the wtCREG and mCREG protein, the ratio of cell in G0/G1 phase increased to 0.5773 and 0.5572 from 0.5308 respectively in OB2 group, which increased to 0.7369 and 0.7034 respectively from 0.6297 in HITASY group;3Role of M6P/IGF2R in CREG biologic function:①ELISA and co-immunoprecipitation showed the wt/mCREG binding to M6P/IGF2R directly.②antibody blocking test: when the anti-IGF2R was added to medium at the same time with wt/mCREG at different concentration(2μg/mL、4μg/mL、8μg/mL),the effects of CREG protein which depressing proliferation, migration, secretion and promoting differentiation were blocked, which had the positive correlation to the concentration of added anti body. The studies showed two combinant CREG promoted VSMC switch to differentiation phaenotype, at the same time, depress VSMC proliferation, migration and secreting extracellular matrix.

上述实验结果证实：两种重组CREG蛋白对VSMC增殖均有剂量依赖性的抑制作用，并且相同浓度的糖基化的CREG蛋白对细胞增殖的抑制效应更为显著，最佳效应浓度为400nM；2两种重组CREG蛋白添加后对HITASY和OB2细胞生物学行为的影响：①CREG蛋白对VSMC迁移的影响：刮伤实验发现，加入最佳效应浓度的wtCREG和mCREG蛋白24h后，OB2组迁移能力下降，HITASY组无明显变化；细胞外基质金属蛋白酶-2，9(Matrix metallo-proteinase 2，9，MMP2 ，9)明胶酶电泳检测和Western blot检测结果证实，两种CREG蛋白均可以使OB2细胞合成细胞外基质MMP2，9减少，而组织金属蛋白酶抑制物(Tissue Inhibitors of Metalloproteinases，TIMPs)增加；②CREG蛋白对VSMC分化的影响：加入400nM的wtCREG和mCREG蛋白12h后，OB2细胞myocardin、SMα-actin、MHC、caldesmin表达增加，LM-1、FN表达减少；③流式细胞仪分析细胞周期和BrDU染色分析证实，加入400nM的wtCREG和mCREG蛋白后，OB2组G0/G1期细胞由0.5308分别增加至0.5773和0.5572，HITASY组G0/G1期细胞由0.6297分别增加至0.7369和0.7034；3M6P/IGF2R在重组CREG蛋白的生物学功能中的调控作用：①免疫共沉淀和免疫荧光双染色分析结果显示，CREG蛋白与M6P/IGF2R存在直接结合；②应用抗体阻断实验：将不同浓度的anti- M6P/IGF2R(2、4、8μg /mL)与两种CREG蛋白同时加入培养液中，CREG蛋白抑制VSMC增值、迁移和合成细胞外基质、促进分化的效应减弱，而且与加入anti- M6P/IGF2R浓度正相关。

What\'s more, different intervals of UV have their own characters in influencing DNA: the damage to some bases by UVA may be more serious than that by UVB, and UVB did more severe damage to some deoxyribose than UVA; however, as far as the pyrimidine bases are concerned, the damage by UVB is by far more serious than that by UVA. These results may indicate that there are preferential damaging sites on DNA molecules caused by UVA and UVB irradiation. Moreover, with UVA or UVB irradiation for a long time, the photoreactivation of DNA occurred. The serious damage to deoxyribose and bases by UVB and UVC may confirm the conformation of cyclobutane pyrimidine dimers and (6-4) photoproducts.

而不同波段紫外辐射对DNA的损伤各具特点并且差异明显，UVA对一些碱基的损伤比UVB要严重，而UVB在对脱氧核糖和磷酸盐的损伤上又比UVA要严厉，但就嘧啶碱基来说，UVB对它的损伤远大于UVA，这似乎表明了不同的紫外波段对生物大分子DNA的损伤是有选择性的。

The main investigation contents include:(1) the effect of slag deoxidizers on reduction velocity of slag and contents of C, Si, Al in steel;(2) the effect of steel deoxidizers on desulphurization;(3) the effect of adding BaO into slag on desulphurization;(4) the effect of magnesium-based desulphurizer on desulphurization ...

主要的研究内容包括：(1)不同炉渣还原剂对炉渣还原速度及对钢液增碳、增硅、增铝的影响；(2)不同脱氧剂对钢液脱硫的影响；(3)顶渣中BaO的配入量对钢液脱硫的影响；(4)镁基脱硫剂钢液脱硫效果及对钢中夹杂物的影响。

This work, concentrated on the asymmetric allylation of aldehydes controlled by different chiral auxiliaries prepared from rotational pure tartaric acid, can be divided into three parts.The first part aims to review the developments of chiral drugs and asymmetric synthesis, from which derived the present research topic backgrounds and works.Synthesis and applications of allylation from aldehydes are the second part of the thesis. By optimizing the reaction conditions, such as solvents, temperature, time and chiral auxiliaries like N,N\'-dibenzyl tartamide, N,N\'-p-dimethylphenyl tartamide, N,N\'-o-dimethylphenyl tartamide, N,N\'-o-dichlorophenyl tartamide, N,N\'-a-dinaphyl tartamide, N,N\'-dicyclohexyl tartamide and N,N\'-diphenyl tartamide, ideal experimenttal conditions are obtained according to HPLC monitoring, as well as the auxiliaries\' recoveries experiments. Starting from benzaldehyde and 3-bromopropaldehyde, N,N\'-dibenzyl tartamide is considered the best auxiliary in this reaction.

本文介绍了醛的不对称烯丙基化反应，以光学纯酒石酸为原料，研究了不同构型手性配体在醛的烯丙基化反应中的立体选择性，全文共分三部分十个章节：第一部分对当前手性药物和手性技术进行了概述，并由此展开了本文的研究背景和任务；第二部分为有机合成部分，对醛的不对称烯丙基化反应进行了深入探讨，以苯甲醛为原料对反应条件进行优化，在优化的反应条件下对制备的七种可回收手性酰胺配体(N-苄基酒石酸二酰胺、N-对甲苯基酒石酸二酰胺、N-邻甲苯基酒石酸二酰胺、N-邻氯苯基酒石酸二酰胺、N-a-萘基酒石酸二酰胺、N-环己基酒石酸二酰胺和N-苯基酒石酸二酰胺)进行筛选，优化配体回收实验条件，最终确定出N-苄基酒石酸二酰胺在苯甲醛的不对称烯丙基化反应中具有较大优越性，结晶回收的手性配体光学纯度保持不变。

The investigation on the concentration of four haloacetic acid s during conventional water treatment process in waterworks and in drinking waters in North China showed that there were only dichloroacetic acids and trichloroacetic acids in waters,and the proportion of TCAA was from 52% to 90%.

对北方某自来水厂常规水处理过程及饮用水体中的4种卤乙酸质量浓度进行了调查，结果表明水体中只存在二氯乙酸和三氯乙酸，其中三氯乙酸所占比例较大，为52%~90%；常规水处理工艺对二氯乙酸有较为明显的去除效果，去除率在15%以上，而对三氯乙酸没有明显的去除效果，但总体而言其对卤乙酸有10%左右的去除率；预氯化对卤乙酸的产生起主导性作用，该处产生的卤乙酸占整个氯化过程产生的卤乙酸总量的60%以上，因此常规工艺有必要从预氯化工艺着手加以改进，来更好的控制卤乙酸的产生量。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。