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Heterotopia is the name given to focal or diffuse collections of ectopic neurons in the cerebral hemispheres, a neuronal migrational anomaly.

皮质异位是指大脑半球的局限性或弥漫性神经元异常迁移,可以分为室管膜下、皮质下以及带状异位

Results (1) 6 cases of Tuberous Sclerosis. Diffused subependymal nodular calcification lesions were found in all cases on unenhenced CT. 4 patients are 2 pairs of mother/child relationship. Both of the two mothers are found to suffer from renal angiomyolipoma.(2)1 case of neurofibromatosis showed abnormal spinal canal: scoliosis of thoracic and lumbar spine, concave change of vertebral posterior border. Bilateral renal hypogenesis was found in this patient. Diffused hyper-density lesions were found in kidney and fatty accumulation was found in back skin.(3)6 cases of Sturge-Weber syndrome. On unenhenced CT, curving and strip-shaped calcifications were found along the parietal and occipital gyrus.

结果 ①结节性硬化6例,所有病例CT平扫见两侧脑室室管膜下多发小结节状高密度钙化灶,其中4例为两对母子关系,并见两位母亲合并有肾脏错构瘤,;②神经纤维瘤病1例,MRI表现为椎管异常,胸腰段脊柱侧弯,椎体后缘呈明显的切凹改变;伴有双肾发育不良,CT示肾内多个高密度影,背部皮肤多量脂肪堆积,③脑颜面血管瘤综合征6例, CT可见顶枕部沿脑回分布的弯曲的条状高密度钙化,部分延伸致侧脑室内,增强后见病灶内有扭曲的条状和结节状明显强化的血管影;④小脑血管瘤病4例,影像学表现为小脑内大囊、小结节样占位性病变。

Rats in the normal group did not receive any intervention.③Proliferating cell nuclear antigen,β-Ⅲ tubulin and glial fibrillary acidic protein expression in ependyma was determined by the immunohistochemical staining and image analysis.

实验评估:采用免疫组织化学染色法和图像分析技术检测增殖细胞核抗原、β-Ⅲ型微管蛋白(Tuj-1)、胶质原纤维酸性蛋白在室管膜下的表达。

In the present study changes of NOS positive cells after injection of LPS and apoptotic ependymal cells, the relationship between expression of immediate early gene c-fos and astrocytes, and comparison of changes between SFO and rest regions of the brain in different time-points were investigated with NADPH-d histochemistry, apoptosis in SITU detection of TUNEL, TEM and SEM, fluorescein double labeling of immunohistochemistry, and laser scanning confocal microscope .

为了证实穹窿下器在脑内免疫调节系统中的作用,在本研究当中,应用了NADPH-d的组化方法、TUNEL末端标记法、扫描及透射电镜方法、免疫组织化学的荧光双标法及激光扫描共聚焦显微镜技术,来研究在腹腔内给予大肠杆菌内毒素后,脑内的一氧化氮合酶细胞的变化、室管膜细胞的凋亡、早期即刻基因c-fos的表达与星形胶质细胞之间的关系,以及穹窿下器与其它脑区相比较时的特异性改变。

In the present study changes of NOS positive cells after injection of LPS and apoptotic ependymal cells, the relationship between expression of immediate early gene c-fos and astrocytes, and comparison of changes between SFO and rest regions of the brain in different time-points were investigated with NADPH-d histochemistry, apoptosis in SITU detection of TUNEL, TEM and SEM, fluorescein double labeling of immunohistochemistry, and laser scanning confocal microscope.

为了证实穹窿下器在脑内免疫调节系统中的作用,在本研究当中,应用了NADPH刁的组化方法、TUNEL末端标记法、扫描及透射电镜方法、免疫组织化学的荧光双标法及激光扫描共聚焦显微镜技术,来研究在腹腔内给予大肠杆菌内毒素后,脑内的一氧化氮合酶细胞的变化、室管膜细胞的凋亡、早期即刻基因(immediate early genes沁-fos的表达与星形胶质细胞之间的关系,以及穹窿下器与其它脑区相比较时的特异性改变。

Results Compared with normal group and sham operated control groups, BrdU positive and Nestin positive cells were increased in the hippocampus, dentate subgranular zone and subependymal zone in operated groups after 24 hours of reperfusion of omni-cerebral ischemia.

结果 脑缺血再灌流24 h后,海马、齿状回和室管膜下区的BrdU阳性细胞和Nestin阳性细胞增多,7~10 d达到高峰,术后20 d仍有表达;在室管膜下区,BrdU阳性细胞和Nestin 阳性细胞有向皮质、海马迁移的现象。

Results compared with normal group and sham operated control groups, brdu positive and nestin positive cells were increased in the hippocampus, dentate subgranular zone and subependymal zone in operated groups after 24 hours of reperfusion of omni-cerebral ischemia. the expression of brdu and nestin reached a peak 7-10 days after the operation, and could still be detected 20 days after the operation. the migration of brdu positive and nestin positive cells to the cerebral cortex and hippocampus was observed in subependymal region.

结果 脑缺血再灌流24 h后,海马、齿状回和室管膜下区的brdu阳性细胞和nestin阳性细胞增多,7~10 d达到高峰,术后20 d仍有表达;在室管膜下区,brdu阳性细胞和nestin 阳性细胞有向皮质、海马迁移的现象。

Dividing stem cells and their transit-amplifying progeny are tightly apposed to SVZ blood vessels both during homeostasis and regeneration.

来自美国和西班牙的Tavazoie等人在文章中表示,成年室管膜下区神经干细胞小生境中存在一种平面脉管从,它们具有特殊的性质。

Subependymal hamartomas are also typical, and those in the foramina of Monro tend to become giant cell astrocyotmas.

室管膜下错构瘤同时也是典型的表现,位于孟氏孔的病变可能会室管膜下巨细胞型星形细胞瘤。

HI resulted in the activation of JAKs-STATs pathway in the subventricular zone and choroids plexus, and this pathway might participated in the pathophysiological process of PVL.

HI后侧脑室室管膜下区和脉络丛JAKs-STATs途径被激活,该途径可能参与PVL的病理生理过程。

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