实验研究

We further evaluated the synergistic cytotoxicity of TRAIL in combination with actinomycin D, cisplatin and paclitaxel in A549 cell lines in vitro and in vivo.

本实验选择了人肺腺癌A549细胞瘤株作为我们实验研究的对象，通过TRAIL对人肺腺癌A549细胞诱导凋亡研究，在A549的荷瘤裸鼠的动物模型上研究了其体内的抗肿瘤活性，并进一步研究了TRAIL与化疗药物放线菌素D(actinomycin D，Act D)、紫杉醇和顺铂(cisplatin，CDDP)的联合作用对人肺腺癌A549细胞的体外协同抗肿瘤活性，通过化疗药物协同增强TRAIL抗肿瘤活性作用机制的初步研究，为降低临床化疗药的用药量，减轻其对机体的不良反应提供一定的理论基础。

Based on the research results of Chaos theory, in this dissertation, it has made detailed analysis of the chaotic signal generator. Firstly, the characteristic and various detection methods of chaotic signal are recommended. Secondly, with the aid of software, such as MATLAB, PSPICE, EWB, etc, discussion of the process of generating chaotic signal proceeds. Through simulation, the output result of several kinds of chaotic circuit are analyzed and compared. Thirdly, aiming at Chuas chaotic circuit, through debugging, the impacts by components and parts in the circuit, such as operation amplifier, capacity, inductor, etc, has been further investigated. And then provides a new scheme to implement Lorenz chaotic system, the circuit design and analysis are presented in detail and it can be realized by the hardware of programmable arrays FPGA, the experimental results indicate that this scheme has the advantages of easy operation, flexible design and high efficiency. An application example in secure communications is also provided. Finally, through picking up the characteristic parameter-Lyapunov exponent of the Chaos we can analyze the performance of different chaotic signal generators.

本文在混沌理论研究成果的基础上，对混沌信号的产生做了详细的分析，涵盖以下内容：首先介绍了混沌的定义，混沌信号的基本特性和各种判别方法，特别是对简单的一维Logistic映射的硬件实现问题做了初步探索；其次对混沌信号的产生方法进行讨论，借助于MATLAB、PSPICE、EWB等仿真软件，对几种混沌电路输出的混沌信号进行了分析比较，并在此基础上针对典型三阶连续自治系统Chua's电路作进一步实验研究，通过混沌电路调试，深入研究电路中各元器件，特别是运算放大器、电容、电感等对混沌信号时域以及频谱的影响；再次研究连续混沌系统的数字化硬件产生，设计了Lorenz混沌电路在现场可编程门阵列FPGA上实现的新方案，在保密通信中的应用实验结果表明该方案具有操作简单、设计灵活、效率高等优点；最后针对不同混沌系统，采取不同算法，提取混沌特性参数Lyapunov指数，进而对不同的混沌信号发生器的性能进行了分析。

Holism is made up of data research and clinical research , and reductionism experimental research and clinical research .

整体论模式包含文献研究和临床研究两个路径，还原论模式包含实验研究和临床研究两个路径，复杂性模式也包含实验研究和临床研究两个路径，合计6个类型。

And an on-line adaptative training algorithm of the weights of neuron is given, which enhances fusion precision of the model, fault tolerance and adaptive ability for subsystems 4 In order to diagnose the soft fault of integrated system, a new fault detection method is proposed based on federated filter, which can detect fault of system in short interval and greatly enhance the method sensitivity to fault A fault diagnosis method of Dynamically Tuned Gyro baesd on parameter estimation of kinetics model of rotor, and signal pretreatment, parameter estimation and strategy of fault identification are studied in detail The method can locate fault of DTG correctly and effectively, which provides a new approach and idea for gyro fault diagonsis 5 In order to diagnose the hard fault of integrated system, fault tree analysis is studied on fault disgnosis of integrated system circuits, and the hardware and software of disgnosis system are developed, with faults located to main module and circuit For futhur diagnosis, an optimal measurement technology in detection of circuits is discussed by improving an algorithm based on information theory, and a pratical method based on half-split method is proposed.

针对组合系统的软故障诊断问题，提出了基于联合滤波模型的一种新的故障检测算法，给出了算法的理论推导过程，该算法能在较短的时间内检测出系统故障，提高了算法对故障的敏感度；研究了基于动调陀螺转子动力学模型参数辨识的故障诊断方法，就其中的信号预处理、参数辨识及故障决策方法等关键技术进行了详细的研究，该方法可以正确、有效地检测与定位动调陀螺故障，为陀螺故障诊断提供了新的途径和思路。 5。针对组合系统的硬故障诊断问题，研究了基于系统浅知识推理的故障树法在组合系统电路子系统故障诊断中的应用，开发了相关诊断系统的软硬件，故障可定位到系统的主要功能模块和电路板级。为了进一步的故障定位，研究了电路板故障的最优检测问题，完善了基于信息理论的优化算法，并提出了基于&对分法&的一种实用的优化算法，故障可定位到电路板的主要功能元件级。在组建的SINS/GPS组合系统实验平台上，针对上述研究内容，进行了大量的实验研究。

Based on international front and hotspot in atmospheric chemistry and aerosol study, considering domestic characteristics of atmospheric pollution, the laboratory has included main research areas below: atmospheric chemical reaction, aerosol chemistry, photochemical pollution, acid deposition chemistry, atmospheric brown cloud, emission characteristics and emission factors of PM and VOCs emitted from various sources, indoor air pollution and its control techniques, health effect of particulate matters, and so on.

研究室的主要研究方向始终瞄准国际大气化学和气溶胶研究和发展的前沿和热点，结合中国大气污染的自身特点，在大气化学反应、气溶胶化学、光化学污染、酸沉降化学、大气棕色云、各种污染源颗粒物和 VOCs 的排放特征和排放因子、室内空气污染及其控制、大气污染的人体健康效应等方面进行实验研究，在上述各方面得出具有国际先进水平的研究成果，建立国内领先和国际先进的学术研究和实验科学体系，确保研究室的学术地位和知名度，与国外相关的研究机构保持同步的发展态势并建立平等的交流机制。

The subject is the sequential reseach of the item of theory and experimentation reseach of hybrid-integrated optical acceleration seismic geophone (No. 49874031) and the item of theory and experimentation reseach of photoelectricity integrated acceleration seismic geophone imbursed (No. 40274047) by naitional neature science fund.

本文研究是国家自然科学基金资助项目&混合型集成光学加速度地震检波器理论与实验研究&(No.49874031)和&光电集成加速度地震检波技术理论与实验研究&(No.40274047)的后期研究课题，旨在将研究成功的各类干涉型光电集成加速度地震检波器推广应用。

There are two phases, which are human experiment and animal experiment respectively, in the laboratory experiment.

实验研究分为人体实验研究和动物实验研究两部分。

Fluidization and Sounding Pressure Characters Experimental Research on Pulsating Fluidized Bed After verifying experimentally the Rijke type self-exciting pulsating fluidized bed combustion, under different operating conditions (different empty cross-section wind speed and inaction bed height), experimental research the oscillation characters of sounding pressure in the pulsating fluidized bed. The results indicate that the sound characters in the Rijke type self-exciting pulsating fluidized bed combustor are the same with it in the Rijke type combustor, the pressure in the combustor oscillate up and down in the sinusoidal manner and the pressure is the superposition of the multiple harmonic waves.

脉动流化床流化与声学压力特性实验研究在实验验证了Rijke型自激脉动流化燃烧概念后，在不同运行条件(空截面风速、静止床层高度)下，实验研究了Rijke型自激式脉动流化床的声压振动特性，研究结果表明：脉动流化床内建立起的声波特性和Rijke型脉动燃烧器内的一样，各点压力呈正弦规律上下振动，且压力是基波幅值最大的多次谐波的叠加。

The simulations in this dissertation, however, strictly mimic the experiments. With the research methods similar to the experiments of glycolytic extracts, the experimental phenomenon ? temporal target waves are first reproduced in numerical simulation, and irregular continuous target waves and spatiotemporal turbulences are observed by elevating the magnitude of the local perturbation which pioneers new directions for the experimental research of glycolytic reactions.

而本文在模拟中严格仿照实验条件，采用酵母抽提物实验中对酵解波的研究方法，第一次在数值模拟中重现了实验现象——暂态靶形波，并通过增加局域扰动的幅度观察到了非规则的连续靶形波和时空湍流，为酵解反应的实验研究开辟了新的方向。

The previous researches have been done experiments mostly in the Water tank. In order to simulate turbulence of flow in river and research its characteristics, the characteristics of turbulence are studied by experiments in the water channel with ADV technique. The research results indicate that R.M.S. velocity linearly relates to the oscillating-grid frequency; R.M.S. velocity decays by power exponent relates to the distance from the grid midplane; and the relationship between the geometrical factors and the free movement space of water is direct proportion.

以往研究大都在水箱中对振动格栅紊流特性进行实验研究，为能模拟天然河道中的紊流，研究天然河道中紊流特性，利用ADV技术在水槽中对振动格栅紊流进行了实验研究研究结果表明：均方根速度与格栅振动频率成线性关系；均方根速度与距格栅中平面的距离成幂指数关系衰减；几何系数与水的自由运动空间成正比关系。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。