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The E-TOF will also be feasible and practical to assist chemists in screening the optimal reaction condition or evaluating the overall efficiency of different catalytic systems for a specific asymmetric reaction.4.For the first time,we explored chiralγ-hydroxy-α,β-acetylenic esters,which were prepared via asymmetric alkynylation,as key intermediates to the synthesis of chiralγ-butyrolactones. This convergent and enantioselective approach to chiralγ-butyrolactones is practical and easily handled with protecting group free.

这一概念包括反应产率、对映选择性、配体用量以及反应时间四个重要反应参数,不仅适用同一反应不同催化体系的横向综合性评价,而且适用于某一特定反应催化体系的优化过程,有助于研究人员选择最佳的反应条件。4、我们发展了以手性γ-羟基-α,β-炔酸酯为关键中间体完成了手性γ-丁内酯类天然产物的对映立体选择性全合成,该关键中间体能够以我们的催化体系方便的对映选择性合成,之后的官能团转换方法成熟,易于操作,无需进行繁琐的官能团保护和脱保护过程,绿色经济。

It realizes and animadverts modernity in its special way by exposing the dark reality mercilessly and reappearing the ugly humanity objectively.

它创造性地把文学和科学结合起来,将生物学、遗传学等自然科学引入文学领域;它运用科学态度和方法指导文学创作,以真实、客观为文学的根本原则和出发点,将写实风格发展到极致;它打破了只从理性层面刻画人物的文学禁锢,从生理层面对人的生物性进行赤裸裸的写真;它通过对黑暗现实的无情揭露、对丑恶人性的客观再现,完成对现代性的独特体认和批判;它前承现实主义,后启现代主义,是文学史从近代向现代过渡中的一次重要的文化超越,具有极为重要的意义。

They are:①completed total 8 000 km long natural seismic profiles cross the northern boundary and central part of the plateau, identified several deep-cut lithospheric faults and low velocity and low density bodies under the central part of the plateau related to Cenozoic volcanic eruption, the Tarim block subducted beneath the Altun Mts;②found the evidence that the Altyn Tagh fault formed in 220~240 Ma and at least 400 km sinistral offset since, and determined quantitatively deformation in Cenozoic;③discovered 350 km long high-ultrahigh pressure metamorphic belt in the south border of the Qilian terrane,which brobably represented the Early Paleozoic boundary between the North China and Yangtze plates;④according to new discoveries of caledonian ophiolite,granite are subducted complex established paleo-collision orogenic framework of northern Qinghai-Tibet plateau;⑤proposed a new model .

本文展示了中法1995~2000年青藏高原北部地学研究的如下主要新进展:①完成8 000 km长的青藏高原北部及中部天然地震岩石圈探测剖面,确定若干条岩石圈断裂,发现与新生代火山喷发有关的青藏高原中部深处的低速、低密度体,塔里木地块俯冲于阿尔金山之下;②提出阿尔金断裂形成于220~240 Ma和左行平移400 km的科学依据及确定其新生代变形量;③确定祁连南缘350 km长的高压-超高压变质带,提出其可能代表早古生代时期北中国板块与扬子板块之间西部界限的新认识;④根据加里东期蛇绿岩、花岗岩及俯冲杂岩带的新发现,初步建立了古碰撞造山格架;⑤提出高原隆升的&地幔底辟和内向陆内俯冲&的新假设。

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

WD40域,在真核蛋白质的数量发现,涵盖了包括各种功能适配器/信号转导,mRNA前体细胞骨架组装加工和管理模式;通常包含一个从11月24日生长激素肽的N残留端和西部数据肽在其C端和40残留长,因而得名WD40;介于生长激素和WD一个保守的核心,作为一个稳定的螺旋桨式平台,可以绑定的蛋白可以稳定或可逆,形成了一个螺旋桨式与每个刀片是一个四叶片结构组成若干链反平行的β-片;与数份检测实例假设,形成了聚大结构,每个WD40重复序列形成了前三个一个刀片和绞线的最后在未来的刀片链,最后C -末端WD40重复完成了第一WD40重复叶片结构,创造螺旋桨的封闭环结构,对螺旋桨顶部和底部表面残留的建议,配合和其他蛋白质的相互作用/或小配体; 7重复副本,目前这条路。

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

WD40域,在真核蛋白质的数量发现,涵盖了包括各种功能适配器/信号转导,mRNA前体细胞骨架组装加工和管理模式;通常包含一个从11月24日生长激素肽的N残留端和西部数据肽在其C端和40残留长,因此得名WD40;之间的生长激素和WD是一个保守的核心,作为一个稳定的螺旋桨式平台,可以绑定的蛋白可以稳定或可逆性;形式与每个刀片是一个四叶片组成的几个类似结构的螺旋桨,搁浅反平行β-负债表;很少检测副本实例假设,形成了聚大结构,每个WD40重复序列形成了前三个链的一个刀片,并在未来的刀片上链,最后C -末端WD40重复完成了第一WD40重复叶片结构,创造螺旋桨的封闭环结构,对螺旋桨顶部和底部表面残留物,则建议协调与其他蛋白质和/或小配体; 7重复副本存在于相互作用这条路。

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are propos

WD40域,在真核蛋白质的数量发现,涵盖了包括各种功能适配器/信号转导,mRNA前体细胞骨架组装加工和管理模式;通常包含一个从11月24日生长激素肽的N残留端和西部数据肽在其C端和40残留长,因而得名WD40;介于生长激素和WD一个保守的核心,作为一个稳定的螺旋桨式平台,可以绑定的蛋白可以稳定或可逆,形成了一个螺旋桨式与每个刀片是一个四叶片结构组成若干链反平行的β-片;与数份检测实例假设,形成了聚大结构,每个WD40重复序列形成了前三个一个刀片和绞线的最后在未来的刀片链,最后C -末端WD40重复完成了第一WD40重复叶片结构,创造螺旋桨的封闭环结构,对螺旋桨顶部和底部表面残留的建议,配合和其他蛋白质的相互作用/或小配体; 7重复副本,目前这条路。

Using the perspective drawing formation principle,this paper makes comprehensive elaboration of one-point perspective,two-point perspectives and three-point perspectives formation principle with the matrix representation method,and infers one essential method to these three kinds of perspectives formation principle which the perspective reverses,uses this essential method to reverse the picture's some characteristic point coordinates,then completes the reconstruction object's three-dimensional model with these characteristic point coordinates and carries on the confirmation using the surface,the body,these two kinds of fundamental elements as examples.

利用透视图的形成原理,对一点透视、两点透视和三点透视的形成原理用矩阵表示的方法作了全面的阐述,并对这三种透视的形成原理进行反推,推导出透视反求的一种基本方法,利用这种基本方法反求出图片的一些特征点的坐标,然后用这些特征点的坐标来完成重建物体的三维模型,并以图像中面、体两种基本元素为例进行了验证。

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