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Methods In this study 2 363 gravidas in mid trimester of pregnancy were included,subjected to MAP measure and followed up to accouchement.

对2 363例中期娠孕妇抽取血标本测定血β-HCG、AFP及UE3值,同时测量MAP,并随访至分娩,观察上述指标与高征的关系。

Their only recourse was to pillory Aristophanes in his turn as a dissolute, Lying Alcibiades of poetry.

真的,在这里我们见到一切神秘天才的一大defectum,所以苏拉格底堪称为特种的非神秘派,他的推理天性因育过久而发展到极点,正如神秘派的直觉智慧发展到极点那样。

Antenatal examination of coagulation function was of high value in prevention and treatment of hypertensive syndrome of pregnancy.

结论产前做凝血功能检测对预防和治疗高征的发生和发展有重要意义。

Monitoring of coagulation and fibrinolysis in women with PIH is very important in predicting development of PIH.

高征患者凝血与纤溶指标监测,对预测高征的进一步发展具有重要意义。

PIH disease pathogenesis, has not yet been clarified, according to the etiology of epidemic survey found that pregnancy causes a high incidence of disease may be related to the following factors:(1) the spirit of excessive tension or by stimulating the central nervous system dysfunction resulting in;(2) the cold season or temperature change is too large, especially at high pressure;(3) of young pregnant women or elderly primipara;(4) has chronic high blood pressure, nephritis, diabetes and other medical history of pregnant women;(5) malnutrition;(6) short body fat;(7) uterine hypertonicity, such as polyhydramnios, twins, diabetes, fetal macrosomia and the mole, etc.;(8) family history of hypertension, particularly pregnant women pregnant mother has history of hypertension.

高症的发病原因,至今还未阐明,根据流行病因学调查发现,高症的发病原因可能于以下因素有关:(1)精神过分紧张或受刺激致使中枢神经系统功能紊乱;(2)寒冷季节或气温变化过大特别是气压高时;(3)年轻孕妇或高龄初产妇;(4)有慢性高血压、肾炎、糖尿病等病史的孕妇;(5)营养不良;(6)体型矮胖;(7)子宫张力过高,如羊水过多、双胎、糖尿病巨大胎儿及葡萄胎等;(8)家族中有高血压史,尤其是孕妇之母有高症史者。

Loweed MMP-9 expression in syncytiotrophoblast might result in defective nidation in the placenta where local ischemia and hypoxia cause abnormal TNF-α elevation, which might be one of the important factors inducing PIH.

高征患者MMP-9表达下降,胎盘不完全侵入,胎盘局部缺血、缺氧,TNF-α表达增多,可能是引发高征的原因之一。

Objective To investigate the expression of cytochrome C oxidase subunit Ⅰ mRNA in the placental villus of preeclampsia.

检测高征患者胎盘绒毛组织中细胞色素C氧化酶亚单位Ⅰ mRNA的表达,探讨线粒体能量代谢与高征发病的关系。

In SPIH, there are depositions of immunocomplex and complement on the vessel walls of placental villus and uteroplacenta.

重度高征时,子宫、胎盘血管有免疫复合物和补体沉积,在高征的发生和发展中,免疫因素起着重要作用。

Results l.Serum concentrations of VCAM-1 in PIH (93.39 + 57.3)ug/ml were higher than that in normal pregnant group. Serum concentrations of VCAM-1 in moderate(97.89 + 34.07)ug/ml and severe PIH(132.24 + 60.97)ug/ml were significantly higher than that in normal group.(P.05, P.01). There was no difference between serum levels of VCAM-1 mild PIH and normal pregnant group. 2.Serum levels of IL-6 in PIH group(102.17 ?48. 31)pg/ml were significantly higher than that in normal group(49.16 + 12.9)pg/ml.Serum levels of IL-6 in moderate(95.79+31.19)pg/ml and severe PIH( 127.27+11.3 8)pg,ml were significantly higher than that in normal group. There was no difference between serum levels of PIH in mild PIH (52.13 + 12.90)pg/ml and normal pregnant group. 3. In PIH group, serum concentrations of VCAM-1 correlate with the levels of IL-6,r=0.63. 4.The expression of VCAM-1 in cytotrophoblast of spiral arteries in normal pregnant group(100%) were significantly higher than that in PIH group.Theexpression of VCAM-1 in moderate PIH(37.50%) and sever PIH were lower than that in normal group.There was no difference between the mild PIH and normal group.Conclusions The increased levels of serum of VCAM-1 may participate in the process of vascular endothelium damages in PIH.

结果 1、高征组血清VCAM-1浓度为(93.39±57.3)μg/ml明显高于正常娠组(44.87±15.60)μg/ml,差别有显著性(P<0.05);中、重度高征组VCAM-1浓度分别为(97.89±34.07)μg/ml和(132.24±60.97)μg/ml,与正常娠组比较,差异有显著性(p<0.05)和非常显著性(P<0.01);轻度高征组VCAH-1为(48.46±15.60)μg/ml与正常娠组比较,差异无显著性(P>0.05)。2、高征组血清IL-6含量为(102.17±48.31)pg/ml,明显高于正常娠组(49.16+12.9)pg/ml,差异有非常显著性(P<0.01);中、重度高征组IL-6含量分别(95.79±31.19)pg/ml和(127.27±11.38)pg/ml,与正常娠组比较,差异有显著性(P<0.05)和非常显著性(P<0.01);轻度高征组IL-6含量为(52.13±12.90)pg/ml与正常娠组比较,差异无显著性(P>0.05)。3、VCAM-1与IL-6水平呈明显正相关,r=0.63(P<0.01)。4、子宫胎盘床螺旋动脉滋养细胞VCAM-1表达,正常娠组都存在阳性表达(阳性表达率100%),高征组有10例阳性表达阳性表达率为叩们,差别有非常显著性河<0.01L 中、重度高征组阳性表达率分别为37、50%和0,与正常娠组比较,差别有显著性河<0.05)和非常显著性汀<0.01太轻度高征组阳性表达率为83.33凡与正常娠组差别无显著性问>0.05)。

Objective: To evaluate the role of malonyl dialdohyde, superoxide dismutase and vitamine E in the pathogenesis of pregnancy induced hypertension.

目的:测定高徵患者血清和脐血中丙二醛、超氧化物歧化酶及维生素E的水平並探討在高徵发病中的作用。

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