奥斯蒙德

Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

Olaf Bininda-Emonds of the Technical University of Munich and his colleagues have done that with the mammals.

这已经被德国慕尼黑的奥拉夫·比琳达·埃蒙德斯博士与他的研究小组在哺乳动物身上得到证实。

Sasha Morris, a play specialist at Great Ormond Street Hospital, London, agreed that parental input is vital.

萨莎莫里斯是一名伦敦大奥蒙德街儿童医院的专家，她也认为家长的照看是至关重要的。

Gregg has performed and recorded with an amazing variety of artists including Santana, Ringo Starr, James Taylor, David Lee Roth, Toto, Joe Satriani, Don Henley, Hans Zimmer, Keiku Matsui, Gino Vannelli, Tania Maria, Brian Wilson, Frank Gambale, Carole King, Robin Zander, Yarborough and Peoples, Andy Summers, Linda Rondstat, Steve Lukather, The Mustard Seeds, David Garfield, Enrique Iglesias, Larry Carlton, Pat Boone's Heavy Metal Big Band, Tribute to Jeff Porcaro, Celine Dion, Steve Vai, and many others.

格雷格的表现和记录的一个了不起的各种各样的艺术家，包括桑塔纳， ringo斯塔尔，詹姆斯泰勒，大卫李罗斯，东陶，乔satriani ，唐亨利，汉斯兹蒙， keiku松井，吉诺vannelli ， tania玛丽亚，布赖恩威尔森，坦诚gambale ，卡罗尔国王，罗宾桑德尔， yarborough和人民，安迪萨默斯，琳达rondstat ，史蒂夫lukather ，芥菜种子，大卫加菲尔德，恩里克伊格莱西亚斯，拉里卡尔顿，八布恩的重金属大乐队，赞扬杰夫porcaro ，席琳狄翁，史蒂夫奥钢联，和许多其他问题。

In 1897 the Calced Augustinians, numbering 319 out of 644 religious then in the Philippine province, had charge of 225 parishes, with 2,377,743 souls; the Discalced, numbering about 220, with 233 parishes and 1,175,156 souls; the Augustinians of the Philippine province numbered in all 522, counting those in the convents at Manila, Cavite, San Sebastian, and Cebú, those at the large model farm at Imus, and those in Spain at the colleges of Monteagudo, Marcilla, and San Millan de la Cogulla.

在1897年的Calced奥古斯丁，编号319的644名宗教然后在菲省，已收取的225堂，与2377743的灵魂；的Discalced ，为数约220 ，与233个教区和1175156的灵魂；的奥古斯丁菲律宾该省编号为522的一切，那些指望在修道院在马尼拉，甲米，圣塞巴斯蒂安，以及宿务，那些在大型示范农场危害，以及那些在西班牙的院校蒙特阿古， Marcilla ，圣密德拉鲁阿Cogulla 。

They came after a long effort by such figures as Simone Veil, a politician and Holocaust survivor, Cardinal Lustiger, former archbishop of Paris of Jewish origin, Claude Lanzmann, director of the 1985 film "Shoah", and Serge Klarsfeld, a Nazi hunter whose father died at Auschwitz, to record the details of every Jew deported from France.

这一评述是在一大批正义之士的长期努力下催生的。这其中包括政治家西蒙娜·韦伊，同时是犹太人大屠杀中的幸存者；前巴黎红衣主教吕斯蒂杰，犹太人出身；导演克劳德·朗兹曼，于1985年拍摄了影片《浩劫》；以及有纳粹猎人之称的瑟奇·克拉斯费德，其父死于奥斯维辛集中营。他们的努力记录下了每一个由法国遣送的犹太人的具体身份。

One of his regular hegiras recently took Miyashita from Austin, Texas, to Butte, Montana, new geographical loci to add to his beloved Portland, Oregon, and Seattle.

追随着Brian Jones流亡的足迹，宫下贵裕从奥斯汀，德克萨斯到比尤特，蒙大纳，以及他深爱的俄勒冈波特兰和西雅图。

Situated beside the Oka River in Nizhny Novgorod Oblast of Russia, Dzerzhinsk is named after the Russian leader Feliks Edmundovich Dzerzhinsky.

捷尔任斯克坐落于俄罗斯下诺夫哥罗德州的奥卡河边，以俄罗斯领导人费利克斯·埃德蒙多维奇花·捷尔任斯克的名字命名。

Indeed, the "costumes" draped on Bond's female sidekicks – including Vesper and raven-haired Solange, the errant wife of Bond's nemesis, crime kingpin Dimitrios – are so of the moment that Casino Royale demands to be seen purely for its style pointers.

事实上，&时装&一直与邦德的女性伙伴们——包括薇斯帕以及一头乌黑秀发的索兰戈，后者是邦德死对头迪米特里奥斯（Dimitrios，西蒙·爱柏凯利安饰）误入歧途的妻子饰）——须臾不离，它们是如此的抢眼，以至于很多人纯粹只为了这些流行风向标而去观赏《皇家赌场》。

Cast :, Manuel Cabral as Simón Bolívar, Julio César Luna as Narrator, Luis Fernando Orozco as Simón Rodríguez, Edgardo Román as Tiránico, Mario Ruiz as Américo, Flor Vargas ..

演员：，曼努埃尔卡布拉尔为西蒙玻利瓦尔，塞萨尔Luna既有讲述，路易斯费尔南多罗斯科为西蒙罗德里格斯，埃德加多Roman作为Tiránico，马里奥鲁伊斯为阿梅，许瓦加斯。。。

It seems likely that Kraft will return with a better offer.

看起来卡夫要重新考虑一个更好的出价了。

But he'd rather burn off my feelers and watch me squirm.

可他却放任那个家伙对我为所欲为！