奋乃静

Objective To establish a rapid and precise continuous flow-injection chemiluminescence method for the determination of perphenazine.

目的建立快速测定奋乃静的流动注射化学发光新方法。

Methods: Sixty three patients with alcohol induced mental disorders were recruited in the study, with 32 treated with tiapride 200 mgd-1±s 12 mgd-1 and 31 with perphenazine 16.0 mgd^(-1)±s 3.4 mgd^(-1) for 8 weeks.

共纳入63例酒精所致精神障碍患者，其中泰必利组32例，剂量为200mgd^(-1)±s12mgd^(-1)；奋乃静组为31例，剂量为16.0mgd^(-1)±s3.4mgd^(-1)；疗程共8周。

Objective:The purpose of this study was to verify the differences between pipothiazine palmitate and fluphenazine decanoate in clinical efficacy and side effect,then offer evidence for clinical medication.

目的：验证哌普嗪棕榈酸酯与氟奋乃静癸酸酯在临床疗效及副作用方面的差异，为临床合理用药提供依据。

Review analysis of drug usage in 462 Schizo phrenia patients was made.

回顾性分析462例精神分裂症的用药。143例单用药7种，频度高者依次为氯氮平，氯丙嗪、氟哌啶醇、奋乃静及舒必利。

The average recoveries were 60.2%~125% and 64.5%~126% for the drugs in plasma and urine except those of perphenazine, thioridazine and chloropromazine in plasma were 37.6%~57.5%, 36.3%~48.3%, 52.4%~67.4%, respectively; trazodone and diazepam in urine were 100%~142% and 108%~177%, respectively. The relative standard deviations of all the drugs in plasma and urine were within 0.8%~26% and 2.6%~18%(n=6), respectively. The detection limits of the 4 barbitals ranged from 20 to 100 mg/L and those of the other drugs ranged from 0.05 to 2.0 mg/L.

血浆样品中待测组分的加标回收率除了奋乃静、硫利哒嗪和氯丙嗪的分别为37.6%～57.5%， 36.3%～48.3%和52.4%～67.4%外，尿液样品中待测组分的加标回收率除了曲唑酮和地西泮的分别为100%～142%和108%～177%外，血浆和尿液中其余待测组分的加标回收率分别为60.2%～125%和64.5%～126%，相对标准偏差分别为0.8%～26%和2.6%～18%(n=6)；除了巴比妥类药物的检出限为20～100 mg/L外，其余药物的检出限均为0.05～2.0 mg/L。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。