失效

Linge Pa found that these drugs can make a number of host proteins failure, but the host Buzhi Yu cause serious side effects, he said: But the virus, at least under the assumption that the current study is absolutely dependent on a particular protein, if you stop of this protein, the virus is not luck, but the host cells could be turned to other proteins, said:'Hey, can you come here?

林格帕发现，这些药物可以令许多宿主蛋白质失效，却不至于引起宿主的严重副作用，他说：可是病毒，至少在目前的研究假定下，绝对要依赖某种特定的蛋白质，如果你阻止了这种蛋白质，病毒就不走运了，但宿主细胞可以转向其他蛋白质说：'嗨，你能过来一下吗？

The marine stern tube bearing is a special structure and complicated load sliding bearing, which is always under foul lubricative state in real work, and always produces bad abrasion to get premature invalidation. This brings a great influence to ship s safely sailing and economic benefit.

船舶尾管轴承是一种受力复杂、结构特殊的滑动轴承，它在实际工作中处于极其恶劣的润滑状态下，常常产生严重的磨损而导致尾轴承的过早失效，这对船舶安全航行和营运经济效益带来很大的影响。

MAMO can be used to compute the real performance of microprocessor based on the contribution to CPI of each microprocessor part computed by the above models.

这一模型主要包括指令窗口模型，功能部件受限模型，分支误预测事件模型，指令和数据Cache失效模型。

" In the face of the absolute immorality and senselessness of millionfold murder political language threatens to fail ."

&在百万重谋杀的极端不道德，无意识面前，政治语言恐怕失效。&

Many people mistakingly interpret the word failure to mean the actual breakage of a part.

很多人错误的把一个零件发生故障或者失效理解成这样就意味着一个零件遭到了实际的物理破损。

Some results obtained are helpful to construct a time-dependent multiaxial fatigue failure model.

并得到一些有助于后续建立时相关疲劳失效模型的规律。

The gaps all over the new type roller can absorb more impact energy than that absorbed by the conventional roller and improve the resistance against the multicycle impact under high-speed operation to avoid its early fracture.

这种滚子周身遍布缝隙，能更多地吸收冲击能，可用来解决高速多冲作用下普通滚子耐冲击性能差、易于出现早期断裂失效的问题，并通过疲劳实验和噪声实验验证了卷制螺旋滚子的优越性。

All internal fixators were removed and re-fixed with half ring sculcus external fixator. For 32 cases with soft tissue defect, 10 were repaired with gastrocnemius musculocutaneous flap, 6 with medial head of gastrocnemius and 16 with fascial flap.

所有病例均取出失效内固定后采用半环槽式外固定治疗。32 例软组织缺损和骨外露，10例经腓肠肌皮瓣转位覆盖，6例用腓肠肌内侧头转位加植皮消除创面，16例采用筋膜皮瓣修复。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

In recent years, NACE T-8 committee, UOP and API have been doing comprehensive research and studying the failure mechanism of REAC.

近年来，NACE T-8委员会、UOP公司和API协会正全面进行REAC管路系统的失效机理研究。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。