失常的

OBJECTIVES: To improve the evaluation of the possible antiarrhythmic effect of statins, we performed a meta-analysis of randomized trials with statins on the end point of incidence or recurrence of atrial fibrillation.

目的：为了评价他汀类可能的抗心律失常效应，对运用他汀的以房颤发生或复发为终点的临床试验进行荟萃分析。

These statistics have sparked a widespread, sometimes rancorous debate about whether people are taking far more medication than is needed for problems that may not even be mental disorders.

这些统计数字引发了广泛的，有时rancorous辩论的人士，是否正在服药更远远超过需要的问题，甚至有可能不会被精神失常。

Conclutions: Under ischemic condition, the decrease of Iks could prolong the mid-late repolarization phase of APD. It could cause EAD and then arouse TdP. Because the decrease of M cell was significantly greater than that of sub-endocardial myocytes and sub-epicardial myocytes, it could increase TDR. Cardiac arrhythmias could last due to reentrance that secondary the increase of TDR.

缺血时，心肌细胞的Iks电流减弱，使得细胞动作电位复极中后期延长，容易出现EAD并引发TdP；由于M细胞的Iks电流减弱程度明显大于心内、外膜细胞，造成心室跨壁复极离散度增加，有利于折返的发生，使得心律失常得以持续。

The variants are not like the mutations most of us learned about in school--alterations that cause entire genes or series of genes to malfunction and that result in diseases like sickle-cell anemia and cystic fibrosis.

这些变异不同于我们大多数人从学校里了解到的基因突变——一种引起全部基因或者几种基因机能的失常，并导致像镰形血球贫血症和囊性纤维变性之类疾病的变化。

Background Slowly activating delayed rectifier potassium currentI_(Ks is important in therepolarization of human cardiomyocyte action potential,especially in forming andmaintaining plateau of action potential. I_ channel is combined byαandβsubunits,which are coded by KCNQ1 and KCNE1 respectively. Mutations ofhKCNQ1/hKCNE1 genes,chronic myocardial hypertrophy and chronic heartfailure will lead to dysfunction of I_ and ingenital or acquired LQTS which areimportant factor in hazardous ventricular arrhythmia such as Torsade depoints.

实验背景缓慢激活延迟整流钾电流I_(Ks是参与人心肌细胞动作电位复极，特别是平台期形成与维持的重要外向离子流。I_通道由KCNQ1基因编码的α亚单位及KCNE1基因编码的β亚单位组成。hKCNQ1/hKCNE1基因突变或慢性心肌肥厚、慢性心力衰竭等病理过程均可导致I_功能异常，引起遗传性或获得性长QT综合征，LQTS易引起尖端扭转型室性心动过速等心律失常，从而危及病人生命。

To investigate the role of transmural dispersion of repolarization and cardiac restitution properties in arrhythimogeneity in LQT2, we observed the effects of d, 1-sotalol, hypokalemia and calcium channel blocker on TDR and cardiac restitution properties at different basic cycle length by using the arterially perfused rabbit left ventricular wedge preparation.

为探讨心室跨壁复极离散度和动作电位时程恢复性质的变化在LQT2室性心律失常发生中的作用，笔者采用冠状动脉灌注的兔左室肌楔形组织块制备LQT2模型。标本随机分四组：对照组；LQT2模型组（100 mol/L d，1-sotalol灌流）；模型+低钾(3 mmol/L)组和模型+低钾+维拉帕米(2 mol/L)组。

Arterially perfused rabbit left ventricular preparations were used in the present study to simulate LQT2 by perfusing with d-sotalol. Transmembrane action potentials from epicardium and endocardium were recorded simultaneously, together with a trasmural ECG, in arterially perfused rabbit left ventricular preparations by use of 2 separate intracellular floating mocroelectrodes.

为探讨心室肌跨壁复极离散和心脏兴奋的恢复性质在长QT综合征室性心律失常发生过程中的作用，应用冠状小动脉灌流的兔左室肌楔形组织块标本，分模型组和对照组，采用浮置玻璃微电极法同步记录心室肌内、外膜心肌细胞动作电位和跨壁心电图。

Objectives The purpose of this study was to evaluate the therapeutic effects and mechanisms of high thoracic epidural blockade on patients with idiopathic dilated cardiomyopathy by detecting heart rate variability , arrhythmias, neurohumoral factors, mortaliity of DCM patients and apoptosis in dilated cardiomyopathy mouse.

目的 研究高位硬膜外阻滞对原发性扩张型心肌病患者心率变异性、心律失常、神经内分泌细胞因子、病死率的影响，对扩张型心肌病大鼠心肌细胞凋亡的作用，旨在探讨该方法治疗原发性扩张型心肌病的疗效及机制。

The most patients have before the morbidity give off heat, the whole body to be sore, cold symptoms and so on pharyngalgia, diarrhea, subsequently presents the chest to be stuffy, the palpitation, the asthenia, disgusting, dizziness and so on, later period's these symptoms are the arrythmia which and the heart failure creates by myocarditis cause.

多数病人在发病前都有发热、全身酸痛、咽痛、腹泻等感冒症状，继而出现胸闷、心悸、乏力、恶心、头晕等，后期的这些症状是由心肌炎造成的心律失常和心力衰竭所引起的。

By correlating the basic science and clinical data, investigators observed that when given prenatally, these drugs can cause functional and behavioral disorders by permanently altering the balance of sympathetic and parasympathetic tone in the individual.

把相关的科学基础和临床数据进行关联，研究人员观察到，如果在产前吃了这些药，可能会永久改变个人交感神经和副交感神经的平衡，从而导致功能和行为的失常。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新