天冬酰胺酸

It is now well understood that asparagine synthetase is composed of two parts: a wedge-shaped place in the two antiparallel β-overlapping layers near the N-terminus that functions in glutamine hydrolysis; a C-terminus responsible for binding of Mg2+ ATP and aspartate.

现又明确天冬酰胺合成酶是由两部分组成：N基末端的两个反平行式β-折叠片层中的楔形部分是负责水解谷氨酰胺的活性部位；C基末端负责结合Mg2+ATP和天冬氨酸。

Only the mutation from G to A at site 1135 changed glycin of the 355th amino acid to asparagine.

只有1135位的G变为A，使编码蛋白的第355个甘氨酸变成了天冬酰胺。

The aspartic acid of aspartame could be replaced by asparagine as reported in the literature.

文献已报道甜味肽的天冬氨酸可被天冬酰胺替换，仍保持甜味。

In this dissertation, systematic and extensive conformational search has been performed for asparagine and aspartic acid in gas phase and solution and the properties of the stable conformers are studied using DFT based first-principles calculation. The concerned properties include geometry structure, IR spectra, conformer distributions, intramolecular interactions, ionization energies and electron affinities, protonation and deprotonation processes.

在本论文中，我们对天冬酰胺和天冬氨酸在气相和溶液中的稳定构型进行了系统而全面的寻找，并研究了其稳定构型的几何结构、红外光谱、构型分布、分子内相互作用、电离能、电子亲合能、质子化和去质子化过程等相关性质。

The unique structure of praline (and its hydoxylated derivative, hydroxyproline) causes this amino acid to play a unique role in protein structure.

天冬酰胺和谷氨酰胺的酰胺基容易被酸和碱水解，分别形成天冬氨酸和谷氨酸。

To analysis bacterial-host infection, an in vitro experiment was first carried out to analyze the acid responses of Yersinia pseudotuberculosis, a gastro-intestinal bacterium, under acidic condition. Metabonomic variation of Y.

到21d时，天冬酰胺和组氨酸浓度降低，而缬氨酸、乳酸、丙氨酸、苹果酸、琥珀酸、GABA、胆碱、β-葡萄糖、果糖、尿囊素、苯丙氨酸、甲酸的含量增高。

Two kinds of polyaspartic acid derivates, i.e. PEG-g-PAsp and PEG-g-PDEA, were prepared through the ring-opening reaction of polysuccinimide by CH3O-PEG-NH2, followed by alkaline hydrolysis and aminolysis, respectively.

通过胺端基聚乙二醇(CH3O-PEG-NH2)开环聚琥珀酰亚胺，进一步碱解和胺解制备了聚乙二醇接枝聚天冬氨酸和聚乙二醇接枝聚乙二胺基天冬酰胺两种聚天冬氨酸衍生物。

The cancers studied here were throat cancer, aute non- lymphoblas He leukem ia and acut lymphoblastic leukemia. The result s indicated that,(1)the levels of Leu, Lys, Ser Asn,Ile,Gly,and Thr were obviously decreased whea lse the levels of orn, Trp evidently increased in cultural liquid of throat can cer cell line indicating that the growth of HepⅡ cell consumed 7 amino acids and releaced 2 amino acids into cultural liquid.(2)the levels of Glu, Gls, Leu, Phe, Tyr and Trp were evidently increased while the levels of Thr , His, Ala decreased in plasma from patient with ANLL. These r esults were consistent with the previous report.(3)the levels of Gly, Trp and Phe in plasma from patients with ANLL evidently de creased and the levels of Ala, His increased after therapy indicating that cance r cells were growing in an anaerobic catabolism state.

这些癌肿包括喉癌HepⅡ细胞，急性非淋巴细胞白血病和急性淋巴细胞白血病，结果表明：(1)喉癌细胞株培养过程中亮氨酸、赖氨酸、丝氨酸、天冬酰胺、异亮氨酸、甘氨酸以及苏氨酸等水平明显降低，而色氨酸水平明显增加，说明喉癌细胞的生长繁殖必须依赖以上7种氨基酸同时释放了色氨酸；(2)急性非淋巴细胞白血病患者血浆中的谷氨酸、甘氨酸、亮氨酸、苯丙氨酸、酪氨酸和色氨酸等水平明显升高，而苏氨酸、组氨酸、丙氨酸等水平明显降低，这些结果与国际报道相一致；(3)经治疗后，ANLL患者血浆中甘氨酸、色氨酸和苯丙氨酸等水平明显降低，而丙氨酸、组氨酸等水平明显升高，表明肿瘤细胞处在无氧代谢。

In this analogue, the hydrogen of amide group could still form a hydrogen bond with the oxygen of ester bond and the ester bond was isosteric with peptide bond.

我们合成了甜味肽的类似物L-天冬酰氨酰-L-α-羟基苯丙酸甲酯，将甜味肽的天冬氨酸替换为天冬酰胺，肽键替换为酯键。

We found that hexanoic acid and octanoic acid are insufficiently soluble (with solubilities of 9.68 and 0.68 mg ml21, respectively, in water) to produce any growth modification in L-asparagine monohydrate crystallization.

我们发现，己酸和辛酸在水中不能充分溶解（溶解度分别为9.68和0.68mg/ml，水溶液中），这一特性使它们对L -天冬酰胺单水合物结晶的生长起修饰作用。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐