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Methods Three doses of etomidate were administered intraperitoneally. Five minutcs later, convulsion was induced by electricity or drugs . The convulsant latency, duration of tonic state, incidence of convulsion, mortality and survival time were noted.

以电刺激或致惊剂〔士的宁、N-甲基-D-天冬氨酸、利多卡因〕建立不同类型的小鼠惊厥模型,观察腹腔注射3种剂量的依托咪酯对小鼠强直性惊厥潜伏期、持续期、惊厥发生率、小鼠死亡率以及小鼠存活时间的影响。

Methods Three doses of etomidate were administered intraperitoneally.Five minutcs later,convulsion was induced by electricity or drugs [strychnine.N-methyl-D-aspartate.lidocanine].The convulsant latency,duration of tonic state,incidence of con-vulsion,mortality and survival time were noted.

以电刺激或致惊剂〔士的宁、N-甲基-D-天冬氨酸、利多卡因〕建立不同类型的小鼠惊厥模型,观察腹腔注射3种剂量的依托咪酯对小鼠强直性惊厥潜伏期、持续期、惊厥发生率、小鼠死亡率以及小鼠存活时间的影响。

The better reaction conditions are as follows: Reaction temperature is 40°C, Reaction time is 5 hour; the ratio of L - phenylalanine to acetic acid and N - formyl - L- aspartyl anhydrideis 1:10.2:1.1, Its yield is 95.4%.

在查阅文献的基础上,得到较优的α-L-天冬氨酰L-苯丙氨酸甲脂盐酸盐的合成方案,在甲醇一水体系中,N-甲酰-α-L-天冬氨酰-L-苯丙氨酸在浓盐酸的作用下60℃水解90分钟,后冷却到15℃加入浓盐酸在20~30℃保温反应96小时,进行甲脂化,形成甲脂盐酸盐,结晶析出。

To analysis bacterial-host infection, an in vitro experiment was first carried out to analyze the acid responses of Yersinia pseudotuberculosis, a gastro-intestinal bacterium, under acidic condition. Metabonomic variation of Y.

到21d时,天冬酰胺和组氨酸浓度降低,而缬氨酸、乳酸、丙氨酸、苹果酸、琥珀酸、GABA、胆碱、β-葡萄糖、果糖、尿囊素、苯丙氨酸、甲酸的含量增高。

Recently,numerous studies proved that each member of secreted aspartyl proteinase have different requirements in temperature and pH,with develop of gene mutation technology further cleared relation between gene expression regulation and organism′s infection sites and state,as well as transcription activation factor effect on expression of each member of secreted aspartyl proteinase.

近年来,大量研究证实了分泌型天冬氨酸蛋白酶各成员对温度、pH值等培养方面有不同的要求,基因突变技术的发展,进一步明确了基因表达调控与机体感染部位、感染状态之间的关系及转录活化因子在蛋白酶各成员表达中的作用。

The cancers studied here were throat cancer, aute non- lymphoblas He leukem ia and acut lymphoblastic leukemia. The result s indicated that,(1)the levels of Leu, Lys, Ser Asn,Ile,Gly,and Thr were obviously decreased whea lse the levels of orn, Trp evidently increased in cultural liquid of throat can cer cell line indicating that the growth of HepⅡ cell consumed 7 amino acids and releaced 2 amino acids into cultural liquid.(2)the levels of Glu, Gls, Leu, Phe, Tyr and Trp were evidently increased while the levels of Thr , His, Ala decreased in plasma from patient with ANLL. These r esults were consistent with the previous report.(3)the levels of Gly, Trp and Phe in plasma from patients with ANLL evidently de creased and the levels of Ala, His increased after therapy indicating that cance r cells were growing in an anaerobic catabolism state.

这些癌肿包括喉癌HepⅡ细胞,急性非淋巴细胞白血病和急性淋巴细胞白血病,结果表明:(1)喉癌细胞株培养过程中亮氨酸、赖氨酸、丝氨酸、天冬酰胺、异亮氨酸、甘氨酸以及苏氨酸等水平明显降低,而色氨酸水平明显增加,说明喉癌细胞的生长繁殖必须依赖以上7种氨基酸同时释放了色氨酸;(2)急性非淋巴细胞白血病患者血浆中的谷氨酸、甘氨酸、亮氨酸、苯丙氨酸、酪氨酸和色氨酸等水平明显升高,而苏氨酸、组氨酸、丙氨酸等水平明显降低,这些结果与国际报道相一致;(3)经治疗后,ANLL患者血浆中甘氨酸、色氨酸和苯丙氨酸等水平明显降低,而丙氨酸、组氨酸等水平明显升高,表明肿瘤细胞处在无氧代谢。

Methods Making a pediculated skin graft on dog's upper lip ,and then got it into oral cavity via the "skin tunnel", laying it on the maxillary bone surface (the same size of the alveolar mucosa has been removed),and suturing the graft edges with its surrouding alveolar mucosa.

目的 观察钛种植体与口腔内非牙龈黏膜软组织形成的界面情况;同时观察种植体与周围软组织间隙&龈沟液&的量及其中的天冬氨酸转氨酶和碱性磷酸酶的水平变化与软组织周围炎症的关系。

Polyaspartic acid was synthesized with maleic anhydride and salvolatile as raw material by the method of thin layer polymerization.

以马来酸酐和碳酸铵为原料,通过薄层聚合制备了聚天冬氨酸,研究了反应物配比、聚合时间及反应温度等因素对聚合物产率、相对分子质量的影响;考察了聚合物用量及相对分子质量对阻垢性能的影响。

OBJECTIVE: To observe whether acidic peptide can inhibit the production of N-methyl-D-aspartate receptor and beta-amyloid in brain, and accelerate the production and excretion of nerve growth factor in rats with Alzheimer disease.

目的:观察酸性肽能否抑制阿尔茨海默病大鼠脑内N-甲基-D-天冬氨酸受体和淀粉样β蛋白的产生以及促进神经生长因子的产生和分泌。

Iminodiacetic acid and aspartic acid reacting with t-butyloxycarbonyl anhydride in the basic solvent system of 1,4-dioxane-water gave better yields than those from conventional t-BuOH/H 2O system method,while glutamic acid in both solvent systems of 1,4-dioxane-water and tetrahydrofuran-water also gave better yield.

其中Boc酐法反应条件温和,操作简便,试剂易得且经济,是实验室制备Boc保护的氨基酸的常用方法。常规Boc酐法多采用叔丁醇水和四氢呋喃水的溶剂体系。我们用常规Boc酐法制备Boc 亚氨基二乙酸时,多次重复,收率总是低于 5 0 %,对天冬氨酸和谷氨酸进行Boc化时也有类似情况。

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