大鼠

The research evaluates and accurately diagnosis sports anemia using, as references, hemoglobin and ferrum.

本研究的目的是建立运动性贫血的动物模型，并对长期运动训练的大鼠不同时期的红细胞膜变化进行研究，以了解运动训练对红细胞的影响，尤其在大鼠出现运动性贫血时以及潜在性运动性贫血的红细胞膜的变化规律，为准确地反映潜在性贫血和防止运动性贫血的发生和发展提供灵敏监测指标，同时结合血红蛋白、铁代谢参数等指标来评价运动性贫血，以增加对运动性贫血诊断的准确度，为防治运动性贫血的发生和发展提供依据。

The transduction pathway of rat stomach fundal 5-HT receptor.

1.5-HT在大鼠胃底平滑肌细胞中对钙离子的调节机制实验中选用单细胞Ca~(2+)时空变化为指标，研究了5-HT在大鼠胃底平滑肌细胞中对钙离子的调节机制。

Methods Rats were randomly divided into several groups. One group of rats received gambogic acid solution containing 0.5% CMC-Na 2 mgmL^(-1, once per day orally for six days. At the same time, the rats in the other group received 0.5% CMC-Na solution serving as blank control group. Blood samples were collect at different time point, and the plasma concentration of cocktail probe drugs was determined by HPLC.

将SD大鼠随机分组，藤黄酸组给予藤黄酸0.5%CMC-Na溶液2mgmL^(-1，以0.5%CMC-Na为空白对照，在一定的时间点采集血样，通过HPLC检测探针药物在大鼠体内的代谢情况，以评价藤黄酸对肝细胞色素P450酶的影响。

Results: Significant morphological changes occurred in the superior cervical ganglionic cell of NTDM rats, while those in the rats of ATDM and NC groups did not occur.

结果 未治疗组糖尿病大鼠交感神经节细胞超微结构发生明显的形态学改变，正常对照组和ARIs治疗组大鼠交感神经节细胞超微结构基本正常。

The biomechanical tests showed that two kinds of artificial bones had not significant difference on compressive strength and Young\'s modulus(P＞0.05),while the flexural strength of nano-nacre artificial bone was less than the control group(P＜0.05).3.The results of CCK-8 showed that the difference were not significant in each group,the proliferation of osteoblast reached the peak at the 5th day;7 days after being co-cultured,the total protein content of study group was higher than control group and blank group(P＜0.05),while the difference between control group and blank group was not significantP＞0.05The difference of alkaline phosphatase activities among three groups was not significant(P＞0.05The SEM view showed that osteoblast attached and grew well in two kinds of artificial bone.4.X-ray photography showed that two kinds of powder started to degrade in 2 weeks;this phenomenon became more appear in 4 weeks,nano-nacre powder degraded faster than micron-nacre powder,while the hole shadow was easy to be found;in 8 weeks,all the femoral holes recovered and returned to normal bone mineral density in all groups.Analysis of tetracycline fluorescent double marks in the hard tissue grinding slices indicated that new bone grew fastest around the bone defect area in study group,while most slowly in blank groupP＜0.05 SEM(scanning electron microscope observation showed that nano-nacre powder degraded more quickly.The same result can be found through the demineralized sections morphometric analysis,and both of the composite artificial bones made from those two kinds of nacre powder had the good connection with the adjacent tissue in rats body without apparent inflammatory response.5.X-ray photography showed that rabbit\'s bone defects healed faster in study group since NNAB implanted than in control group since MNAB implanted.At 24 weeks after operation,bone density in radial defects had nearly accessed to the normal area,while lower in control group,and turned up nonunion in blank group;The checking of BMD showed that results in study group were higher than those in control group at 8,16 and 24 week(P＜0.05), and the difference between the BMD values in study group at 24 week and those in blank group was not significant(P＞0.05).The gross specimens showed satisfactory histocompatibility both in study group and in control group,with bone tissue growing from two sides into the center of implanted materials; Normal slices in HE stain and hard tissue grinding slices in Stevenel\'s blue/Van Geison\'s picro-fuchsin stain showed that the bone growth tendency was better in study group than that in control group,and the medullary cavity had been penetrated to the implanted materials in study group at 24 week;Analysis of tetracycline fluorescent double marks in the hard tissue grinding slices indicated that new bone in both groups grew fastest 8 weeks after surgery,while slow down at 16 week.

纳米珍珠层/消旋聚乳酸复合人工骨与微米珍珠层/消旋聚乳酸复合人工骨分别与成骨细胞共培养后，其各时间点CCK-8法检测值与空白对照无显著差异(P＞0.05)，成骨细胞均在第5天达到增殖高峰期；培养7天后，实验组细胞蛋白含量高于对照组及空白组(P＜0.05)，后两者之间则无显著差异P＞0.05碱性磷酸酶活性在三组间均无显著差异(P＞0.05电镜下可见成骨细胞在两种人工骨上都有良好生长贴附能力。4.X-ray显示两种粉体在大鼠股骨骨洞植入第2周时都开始出现了降解，第4周时更为明显，纳米珍珠层粉较之微米珍珠层粉降解更快，而空白对照组骨洞阴影仍可见，至8周时，则所有组骨洞均己闭合修复，X-ray下已不可见原钻孔痕迹，恢复正常骨质密度；硬组织磨片四环素荧光双标记结果显示纳米珍珠层粉植入组较其余两组在骨缺损区周围新骨生长速度更快，空白组速度最慢P＜0.05电镜观察及常规脱钙切片亦可见到纳米粉体降解较快；由以上两种原材料制得的纳米珍珠层/消旋聚乳酸复合人工骨与微米珍珠层/消旋聚乳酸复合人工骨在大鼠体内均与周围组织结合良好，无明显炎症反应。5.X-ray显示纳米珍珠层/消旋聚乳酸复合人工骨植入兔桡骨缺损区后其骨愈合速度较对照组微米珍珠层/消旋聚乳酸复合人工骨植入的快，至植入术后24周，实验组骨缺损区接近正常骨密度，对照组骨缺损区密度较低，空白组则呈现骨不连状态；骨密度测量结果显示术后8周、16周、24周实验组的骨密度值高于对照组(P＜0.05，24周实验组的骨密度值与术前所测得的正常值无显著性差异P＞0.05动物取材大体所见均显示组织相容性良好，骨组织逐渐由植入材料两端向中央生长；常规切片HE染色及硬组织磨片Stevenel\'s blue/Van Geison\'s picro-fuchsin联合染色均可见实验组骨缺损区长势优于对照组，至术后24周，实验组骨髓腔与材料已呈相交通状；硬组织磨片荧光显微镜下观察，两组材料在术后8周处于骨生长最快速时期，16周时速度开始减慢，术后4、8、16周时实验组的新骨生长速度均较对照组的快

The high concentration sevoflurane anesthesia can induce temporary cognitive decline and decrease IGF-Ⅰ expression in hippocampal CAI area of gerontal rats. It is demonstrated that the endogenous IGF-Ⅰ expression levels declining may play an important role in the development process of cognitive disturbances of senile rats.

高浓度七氟烷可在短时期内降低老年大鼠认知功能，可能与海马CAI区IGF-Ⅰ含量降低有关，内源性IGF-Ⅰ的表达减少可能在老年大鼠认知功能障碍的发生、发展过程中起到重要作用。

Results The pathological symptom of DN occurred in all model rats.The renal pathological structure,thickening of glomerulose basement membrane and increasing of fibronectin and collagen IV expression in renal tissue were significantly de-creased in HDC by given HDC.

结果 高血糖组大鼠均出现DN病理学特征，黄丹益肾胶囊用药组大鼠DN病理学改变明显减轻；肾小球基底膜增厚较模型组对照组小；肾组织纤维连接蛋白、肾组织Ⅳ型胶原表达明显低于模型对照组。

The study on pharmacokinetics of Glycocholic acid in rats Solid extraction -reversed-phase high performance liquid was used to detect the concentration of glycocholic acid in blood serum,liver, kidney and brain tissue in rats.

甘氨胆酸在大鼠体内的药代动力学研究采用固相萃取-反相高效液相色谱法测定了大鼠血清及肝、肾、脑组织中甘氨胆酸的含量。

To investigate the change of the portal venous pressure, conjugated glycocholic acid and pancreatic glucagon concentration in rats peripheral and portal venous blood in the course of experimental liver cirrhosis induced with carbon tetrachloride and to investigate the mentioned changes after portal-azygous devascularization.

袁晖应用四氯化碳诱发建立大鼠肝硬变模型，以观察大鼠肝硬变形成过程中和行门奇静脉断流术后门静脉压力、门脉及外周静脉血中甘氨胆酸和胰高糖素的变化。

Methods］ninety femal sd rats,weight 230～280 gram,were rangdonmized into three groups: qiangguyin group,miacalcic group and control group.all rats were variectomized.after 10 weeks,the osteoporosis model succeed,the treatment group,contrast group were given qiangguyin,miacalcic respectively.the treatment group used qiangguyin everyday,1ml/g.the contrast group used miacalcic 0.72u/kg,everyday hyodermic.and 3,4.5,6 months after the treatment,kill 10 rats to explore.the neck of femur were cut and stined with masson golder trichrome for bone histomorphomemetric contrast group analysis.

方法］健康雌性sd大鼠90只，体重230～280g。随机分为3组，分别为治疗组、对照组和空白组，每组30只。分别采取切除双侧卵巢方法进行骨质疏松造模，10周造模成功后，开始给药，治疗组用自拟强骨饮灌胃，每日一次，每次1ml/g，对照组用密盖息，皮下注射，每日1次，每次0.72u/kg。空白组，不做处理。在给药后3、4.5、6个月每组各取10只大鼠进行检测，先测量体重，空气栓塞处死，分离股骨颈，获得股骨颈样本，经切片等处理后，显微镜下作骨形态计量学检测。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。