大鼠

Consequently, studying the effect of aluminium on Long-TermPotentiation and approaching its possible mechanisms can elucidate the mechanisms ofaluminium on study and memory. The research indicated that the pregnant and lactational stage is the importantstage for the filial brain growth and development.

因此本次实验采用整体动物实验的方法，通过对大鼠孕哺期慢性铝暴露，以子代大鼠海马为研究对象，探讨大鼠孕哺期铝暴露后对其子代大鼠海马LTP形成、维持的影响，并从蛋白激酶C表达的途径为阐明铝影响LTP的机制提供思路。

The result showed that Insulin capsule could increase the insulin sensitivity of model rat of insulin resistance of typeⅡdiabetes mellitus by decreasing its blood sugar,decreasing its avoirdupois,improving its lipodystrophy and hemodynamics , increasing its GLUT4 translocation of skeletal muscle cell,increasing expression level of GK in liver cell, increasing expression level of PEPCK and decreasing level of TNF-αexpression in adipose tissue.

结果表明，胰苏灵胶囊可使2型糖尿病IR模型大鼠的血糖降低、体重减轻、脂质代谢异常得到改善、血流变异常得到改善；能使模型大鼠的脂肪组织TNF- a的mRNA表达水平降低，能使模型大鼠骨骼肌细胞的GLUT4的转位增加，能增加肝GK表达，能诱导PEPCK的转录。通过以上作用，胰苏灵胶囊可使2型糖尿病IR大鼠模型的IR得到改善。

Results: 1 Intense ERα immunoreactivity localized in the hypertrophic and maturative layer, and some immunoreactivity was found in osteoblasts of mandible and temporal bone, while no immunoreactivity was found in the disc and synovium. 2 The expression of ERα in male rats TMJ cartilage was higher than that in female ones. 3 In the condyle cartilage of male rats, the density of ERα positive cells decreased with age, which kept stable after 16 weeks of age. 4 In the condyle cartilage of male rats, the density of ERα positive cells was stable from birth to 8 weeks, but decreased from 16 weeks to 12 months, while the density in 18-month group recovered to the level of 8 weeks. Conclusion: TMJ is one of target organs of estrogen, and ERα plays an important role in the effect of estrogen on TMJ.

结果：1TMJ中ERα主要在髁突软骨的肥大层和过渡层表达，下颌骨和颞骨的骨细胞也有少量表达，而关节盘、滑膜中几乎无表达；2雄性SD大鼠髁突软骨中ERα的表达明显强于同龄的雌性大鼠；3在雄性大鼠TMJ髁突软骨中阳性细胞密度随年龄增长逐渐降低，16周以后逐渐维持在相对稳定的水平；4雌性大鼠从出生后到8周龄阳性细胞密度基本稳定，在16周龄至12月龄年龄组阳性细胞密度显著降低，而在18月龄后又恢复到8周龄以前的水平。

Methods 120 SD rats were divided randomly into blank group, model group, Baoliezhi control group and Qianliening granule groups with different doses. The models were established with hypodermic injection of testosterone propionate at 4 mg/kg after orchiectomy, at the same time, these rats were gastric perfused with different drugs respectively for 30 days. The body weight, prostate weight, prostate index, morphological changes, the level of T and E2 were measured. Results The body weight in model group was significantly lower than that in control group (P.05), the prostate weight and index were obviously higher than that in control group (P.01). The prostate weight and index were decreased significantly in Qianliening granule groups with meddle and high doses (P.01), the level of testosterone was increased significantly and E2 was decreased obviously in Qianliening granule group with high doses.

将雄性SD大鼠60只，随机分成空白组、模型组、保列治治疗对照组、前列宁颗粒低、中、高剂量组，采用丙酸睾丸酮皮下注射引起大鼠前列腺增生模型，连续给药30d后，观察6组动物体重前列腺湿重前列腺指数前列腺组织形态血清睾酮雌二醇(E2)水平的变化结果模型组大鼠体重较正常组明显减轻(P.05)，而前列腺重量和前列腺指数明显升高(P.01)；前列宁颗粒中、高剂量组的前列腺重量和前列腺指数明显下降(P.01)；前列宁颗粒高剂量组可明显升高大鼠血清T水平，降低E2水平，使T/E2比例升高。

Methods Diabetic rat models were prepared by giving alloxan. After administration of sodium orthovanadate for seven days, the blood glucose levels of rats were determined. The glucose tolerances of diabetic rats were evaluated by the oxidation-enzyme method, and the insulin levels were determined by radioimmunoassay.

建立四氧嘧啶诱导的糖尿病大鼠模型，对正常大鼠及糖尿病大鼠给予原钒酸钠治疗7天后，采用葡萄糖氧化酶法测定大鼠的血糖值、糖耐量，并以放射免疫法测定血清胰岛素值。

objective:to study the effects of mice and rats' gastrointestinal frnction on phellodendron amurense and its different processed products.methods:decoction of phellodendron amurense and its different processed products were fed to mice and rats,to observe the gastric emptying and gastrointestinal movement of mice;to determined the gasteic juice's acidity of rats by titration,and the pepsin was measuerd by mett's method.

摘 要：目的：研究黄柏及其不同炮制品对小鼠及大鼠胃肠功能的影响。方法：以黄柏及其不同炮制品的提取物灌胃，观察小鼠胃排空及小肠推进情况；观察不同药物对大鼠的胃液分泌情况的影响，用滴定法对大鼠的胃液的总酸度进行测定，用改良mett氏法对大鼠的胃蛋白酶活性进行测定。

Results In atropine group the function of isolated rats phrenic diaphragm was significantly less than that in control group (P＜0.01). In atropine plus PAM-CI group the function of isolated rats phrenic diaphragm was similar to control group.

结果 阿托品治疗组大鼠与空白对照组大鼠的单收缩和强直收缩有明显区别(P＜0.01)，而阿托品加氯磷定治疗组大鼠与空白对照组大鼠的单收缩和强直收缩无明显的区别(P＞0.05)。

Cognitive behavior of the grown-up offspring that the clozapine-exposed in pregnance lead to the the retardation of the weight of filial rats in earlier age.

体格生长：子代大鼠出生后第4天和第7天，对照组和用药组大鼠的体重差异有显著性(F=12.56，P＜0.01；F=7.51，P＜0.01)11，17天则没有差别，显示氯氮平孕期给药可导致子代大鼠早期的体重增长迟缓；孕期使用氯氮平对子代大鼠耳廓分离，出牙时间，开眼时间没有影响。

Methods: A brain concussion was produced in rats using a simple pendulum device model. One control (n=12) and six experimental groups were used(n=12 in each group). The cerebral concussion groups were assigned to sacrifice times ranging from 1 day to 24days after injury.A Morris Water Maze memory paradigm was used to assess learning and memory function. Pycnosis degeneration or necrosis neurons in the locus cerebral cortex, dorsal hippocampus, dentate fornix and brainstem reticular formation were observed and counted after brain concussion. Cholinergic neurons in the basal forebrain and brainstem reticular formation were identified and quantitated using choline acetyltransferase.

应用自制单摆式闭合性机械打击装置建立脑震荡大鼠模型；成年SD大鼠随机分为1个对照组(n=12)和6个脑震荡组(即伤后1、2、4、8、16、24d，n=12)；应用Morris水迷宫(Morris Water Maze，MWM)实验评价大鼠的学习记忆功能；用光镜对大鼠的上述脑区的固缩变性坏死细胞进行观察和计数；用免疫组化方法检测基底前脑和脑干网状结构的胆碱乙酰转移酶(cholin acetyltransferase，ChAT)阳性细胞的表达。

Results(1) Group of electroacupuncture in Shu and dense wave can significantlyreduce the degree of ankle swelling(P＜0.05, P＜0.01), which shows thatelectroacupuncture has obvious anti-inflammatory and repercussive roles;(2) Theresults of HE staining showed that group of electroacupuncture in Shuand dense wave can significantly reduce inflammatory cell infiltration,inhibit synovial cell proliferation, and decrease proliferation of granulationtissue in rats joints;(3) group of electroacupuncture in dense-wave can increase the pain thresholdof experimental rats (P＜0.05, P＜0.01), reduce the content of peripheral painmediums, such as K~+, DA and 5-HT(P＜0.05, P＜0.01), which shows thatelectroacupuncture has significant analgesic effect;(4) In the local lesion of joints, electroacupuncture can significantly reducethe content of IL-1β, IL-8, TNF-a, increase IL-4 content, decrease theexpression of COX-2mRNA, and significantly promote the expression ofHSP-70 protein in synovial tissues of acute gouty arthritis rats (P＜0.05,P＜0.01),thus restrain the occurrence of synovial tissue inflammation.

结果：(1)电针疏密波组能显著减轻踝关节肿胀度(P＜0.05，P＜0.01)，表明电针有明显的抗炎消肿作用；(2)HE染色显示：电针疏密波组可使大鼠关节炎症细胞浸润明显减轻，滑膜细胞增生明显被抑制，肉芽组织增生明显减少；(3)电针密波组能提高实验性大鼠痛阈(P＜0.05，P＜0.01)，降低外周疼痛介质K~+、DA、5-HT的含量(P＜0.05，P＜0.01)，表明电针有明显的镇痛作用；(4)在病变关节局部，电针能显著降低急性痛风性关节炎大鼠滑膜组织IL-1β、IL-8、TNF-α含量(P＜0.05，P＜0.01)，升高IL-4的含量(P＜0.05，P＜0.01)，并降低关节滑膜内COX-2mRNA的表达(P＜0.05，P＜0.01)，可促使急性痛风性关节炎大鼠滑膜内HSP-70蛋白表达显著增加(P＜0.05，P＜0.01)，从而抑止滑膜组织炎症发生。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。