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The C response of semimembranous and semitendinous myoelectricity evoked by stimulation to rat intraplanta with high intensive currents was used to illustrate the peripheral analgesic effect of BmK when given in local cutaneous sensory fields.

方法采用局部皮肤感受野给药,以强电流刺激大鼠后肢趾部诱发半膜半腱肌发放C反应,观察对外周神经系统的镇痛作用;经脊髓蛛网膜下腔给药,以大鼠足跖辐射热痛阈的变化为中枢镇痛效应的观察指标。

METHODS: Thirtysix SD female rats were randomly separated into 3 groups (n=12 in each one) according to the infarction duration (1, 3, 28 d), which were randomly and evenly again separated into 2 subgroups: operated group and sham operated group. The levels of mRNA expression of ACE2 in the noninfarct and infract area of left ventricle 1, 3, 28 d after AMI were detected by RTPCR and analyzed semiquantitatively by imageanalysis system.

将36只SD雌性大鼠按时间段随机分为3组(每组12只),每组再随机分为假手术组、手术组2个亚组(每组6只),应用RTPCR方法检测大鼠AMI后1,3,28 d左心室梗死区及非梗死区心肌ACE2 mRNA的表达,并以图像分析系统对其进行半定量分析。

METHODS摘要: Thirtysix SD female rats were randomly separated into 3 groups (n=12 in each one) according to the infarction duration (1, 3, 28 d), which were randomly and evenly again separated into 2 subgroups摘要: operated group and sham operated group. The levels of mRNA expression of ACE2 in the noninfarct and infract area of left ventricle 1, 3, 28 d after AMI were detected by RTPCR and analyzed semiquantitatively by imageanalysis system.

方法摘要:将36只SD雌性大鼠按时间段随机分为3组(每组12只),每组再随机分为假手术组、手术组2个亚组(每组6只),应用RTPCR方法检测大鼠AMI后1,3,28 d左心室梗死区及非梗死区心肌ACE2 mRNA的表达,并以图像分析系统对其进行半定量分析。

The anti gastric ulcer effects of Xuedan was investigated with gastric ulcer models induced by being immersed in cold water,having pylorus ligature and HAC injected into serous membrane in rats. The influence of gastric juice secrete in normal rats, the anti inflammation action resulted from auricle swelling in mice, the analgesic action by mice body torsion method and the bacteriostotic effect in vitro were observed.

采用大鼠应激性胃溃疡、幽门结扎性胃溃疡、醋酸致胃溃疡等模型观察雪胆提取物抗胃溃疡作用;对正常大鼠胃液分泌的影响;小鼠耳廓肿胀抗炎试验,扭体法镇痛试验以及体外抑菌试验。

Methods seventy-two 15-week-old sd rats were divided into six groups,included control group and five ovariectomized model groups.the model groups were fed with different-dose lycopene[10,15,20 mg/] for 12weeks.then related indexes including length bone mineral density,bone mineral,serum estradiol,sertum alp and uterus index were analyzed.results compared with model group,three different dose groups and nilestriol[1.05mg/] group showed increased bone mineral density,bone mineral,serum estradiol and uterus index,but decreased serum alp (p.05).conclusion as a female sex hormone-like component,lycopene may ameliorate the bone quality and inhibit osteoporosis in ovariectomized rat.

将72只15周龄sd大鼠随机分为6组,空白组做假手术,其余5组做卵巢切除术,术后用药12周后处死,测定右侧股骨骨密度、骨矿含量、血清雌二醇、碱性磷酸酶含量及子宫湿重。结果番茄红素高[20mg/]、中[15mg/]、低剂量组[10mg/]、尼尔雌醇组[1.05mg/kg·bw]能对抗骨密度、骨矿含量、血清雌二醇的下降、血清碱性磷酸酶的升高,与模型组比较,p.05;番茄红素各剂量组、尼尔雌醇组能对抗子宫指数的减轻,与模型组比较,p.05。结论番茄红素可以改善骨质量,抑制大鼠去卵巢骨质疏松的发生。具有类似雌激素的效应。

It can reduce the expression and activation of Stat3 in kidney tissue of chronic serum sickness glomerulonephrits rats, which might be one of the mechanisms of its effectiveness in treating nephritis.

中药肾华与西药福辛普利进行比较,对大鼠改良慢性血清病肾炎模型有良好的降低蛋白尿、升高血清白蛋白、减轻病理变化、减少免疫复合物沉积等治疗作用,而其降低大鼠慢性血清病肾炎模型肾组织内Stat3表达及活化,可能是其减轻肾炎病变程度的机制之一。

YIQIHUOXUEFANG can relieve the myelin sheathe swollen of the nerves and the disease of the sciatics, and promote local vessel density around the myelin sheathConclusionsYIQIHUOXUEFANG can regulate blood glucose effectively, improve the mico-circulation around the sciatics of the diabetes rats, restrain the metabolism of the multi-alcohol, increase the expressions of the NGFand MBP, i.e.

益气活血方能有效地调节血糖,改善DM大鼠坐骨神经周围微循环,抑制多元醇代谢,有醛糖还原酶抑制剂样作用,升高Na~+-K~+-ATP酶活性,改善和提高神经传导功能,促进坐骨神经神经生长因子和碱性髓鞘蛋白的表达,可明显缓解DM大鼠周围神经的早期病变,有一定的神经修复作用,综合疗效优于弥可保。

The results of MTT method In vitro culture renal tubular cells showed that the proliferous activity changed from sightly to dramatically intensed in response to fluoride concentration from 0.1mg/L to 15mg/L, but renal tubular cells proliferation obviously decreased in the 25mg F-/L group.

利用生物化学方法检测氧化应激指标,结果表明在钙营养充分的条件下,投氟100mg/L 16周大鼠肾组织GPX活性不是下降而是明显提高,脂质过氧化物变化不明显;低钙饲养条件下投氟100mg/L 16周大鼠抗氧化酶SOD活性亦有明显升高,而GPX却呈降低趋势。

Methods Cultivation of alveolar type Ⅱ cells were mode from normal adult rat and of silicotic animal model of rat was established.

分离培养正常成年大鼠肺泡Ⅱ型细胞,建立大鼠矽肺模型,用原位杂交和免疫组化技术检测体外培养的和矽肺病变中的肺泡Ⅱ型细胞TGFβ1和PDGF BmRNA和蛋白的表达。

Methods Cultivation of alveolar type Ⅱ cells were mode from normal adult rat and of silicotic animal model of rat was established. In situ hybridization and irnmunohistochemieal staining were applied to detect the gene expression of TGFβ1 and PDGF-B in the alveolar type Ⅱ cells of primary culture and silicotic tissue.

分离培养正常成年大鼠肺泡Ⅱ型细胞,建立大鼠矽肺模型,用原位杂交和免疫组化技术检测体外培养的和矽肺病变中的肺泡Ⅱ型细胞TGFβ1和PDGF-B mRNA和蛋白的表达。

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