大鼠

Endogenous BDNF affected myelination of postnatal peripheral nerve through p75 and NP-kappa B signal transduction pathway.

内源性BDNF影响出生后大鼠周围神经的髓鞘化，尤其在早期作用明显；内源性BDNF主要通过p75和NF-κB信号途径调节出生后大鼠周围神经的髓鞘化。

In contrast, nasal administration of a mixture of MBP6886 and 8799 completely blocked gpMBPinduced EAE even at lower dosage than being used alone. Rats tolerized with MBP6886+8799 nasally showed decreased T cell responses to MBP, reflected by lymphocyte proliferation and IFNγ ELISPOT assays.

淋巴细胞增殖实验和IFNγ ELISPOT检测显示，与鼻黏膜给予大鼠MBP110128组相比，鼻黏膜给予大鼠MBP6886+8799可降低T细胞对于MBP的反应性，淋巴结单核细胞中表达IFNγ和TNFα mRNA的细胞数减少，而两组表达TGFβ及IL4 mRNA的淋巴细胞数都低。

After 1% Nembutal (35mg/kg) was injected anaesthesia, we applied OHBA SIKI spinal cord beat equipment and finished contusion model (beat intensity is 25 Vgram-cm force, gcf) with animal of the latter three groups, only laminectomy of T8-9 were finished on the rats of control group.

除正常对照组外，其余三组大鼠使用OHBA SIKI打击器（Tokyo，Japan）按Gruner改良法作成T9脊髓背侧损伤模型，打击强度为25势能克厘米（Vgram-cm force， gcf），并于打击前向生理盐水对照组和CCK-8治疗组大鼠自尾静脉分别注入生理盐水及胆囊收缩素八肽（CCK-8 40ug/kg）0.2ml。

In young rats,the glomerular filtration rat e and single nephron GFR were unchanged.In old rats the GFR and SNGFR fell significantly.

对年轻大鼠，不改变肾小球滤过率和单个肾单位GFR；对老年大鼠GFR和SNGFR显著下降。

Objective: To observe the effect of Shen'An Chongji on T lymphocyte cell subsets in kidney of rats with adriamycin nephrosis, and to explore its mechanism of kidney protecting.

观察肾安冲剂对阿霉素肾病大鼠T细胞亚群的影响，探讨肾安冲剂对阿霉素肾病大鼠保护作用机制。

MATERIALS: A total of 60 female SD rats, weighing 180-220 g, of clean grade, were used to establish models of adriamycin nephrosis.

材料：清洁级雌性Sprague-Dawley大鼠60只，体质量180~220 g，用于制备阿霉素肾病大鼠模型。

ObjectiveTo observe and explore the effect of aluminum on mitochondria in nerve cell s of rats.

目的通过体外培养大鼠神经元细胞来探讨铝对大鼠神经元线粒体的影响。

Results ①Compared to sham group, ISH and IHC of rat hypothalamic CRHshow positive cells numbers increase, positive areas enlarge and average gray scaledecreases, which reveals the expression of hypothalamic CRH neurons enhances afterPX;②The enhancement of ISH and IHC of hypothalamic CRH in PX rats aftermelatonin supplementation dose-dependently recovers, but it can't return to be normaleither in high dose group or in low dose group and either at 4th week or at 8th week;③IHC of CRH in median eminence of neurohypophysis shows positive areas enlargeand average gray scale decreases, which reveals the releasing of CRH fromhypothalamic CRH neurons increases;④ELISA of CRH in serum shows thedifferences of CRH concentrations among all groups are not significant, which indicates PX and melatonin supplementation have no significant effect on CRH levels.

结果： ①松果体摘除后大鼠下丘脑室旁核CRH 原位杂交和免疫组化的结果与假手术对照组相比均显示阳性细胞数增多、阳性面积增加、平均灰度降低，提示松果体摘除后下丘脑CRH 神经元的表达增强；②松果体摘除大鼠补充褪黑素后，下丘脑CRH 原位杂交和免疫组化染色增强呈剂量依赖性恢复，不过不论是低剂量组还是高剂量组，也不论是术后4 周还是术后8周，均不能恢复至正常；③松果体摘除后神经垂体正中隆起CRH 免疫组化结果显示阳性面积增加、平均灰度降低，提示下丘脑CRH 神经元释放CRH 增加；④ELISA 法检测血清CRH结果示各组血清CRH 浓度差异没有显著性，表明松果体摘除及补充褪黑素对血清CRH 水平没有显著影响。

Results ①Compared to sham group, ISH and IHC of rat hypothalamic CRHshow positive cells numbers increase, positive areas enlarge and average gray scaledecreases, which reveals the expression of hypothalamic CRH neurons enhances afterPX;②The enhancement of ISH and IHC of hypothalamic CRH in PX rats aftermelatonin supplementation dose-dependently recovers, but it can't return to be normaleither in high dose group or in low dose group and either at 4th week or at 8th week;③IHC of CRH in median eminence of neurohypophysis shows positive areas enlargeand average gray scale decreases, which reveals the releasing of CRH fromhypothalamic CRH neurons increases;④ELISA of CRH in serum shows thedifferences of CRH concentrations among all groups are not significant, whichindicates PX and melatonin supplementation have no significant effect on CRH levels.

结果： ①松果体摘除后大鼠下丘脑室旁核CRH 原位杂交和免疫组化的结果与假手术对照组相比均显示阳性细胞数增多、阳性面积增加、平均灰度降低，提示松果体摘除后下丘脑CRH 神经元的表达增强；②松果体摘除大鼠补充褪黑素后，下丘脑CRH 原位杂交和免疫组化染色增强呈剂量依赖性恢复，不过不论是低剂量组还是高剂量组，也不论是术后4 周还是术后8周，均不能恢复至正常；③松果体摘除后神经垂体正中隆起CRH 免疫组化结果显示阳性面积增加、平均灰度降低，提示下丘脑CRH 神经元释放CRH 增加；④ELISA 法检测血清CRH结果示各组血清CRH 浓度差异没有显著性，表明松果体摘除及补充褪黑素对血清CRH 水平没有显著影响。

Objectve To establish the blast-chemical combined injury model by the explosion of nitrogen tetroxide and UDMH, and investigate the pathologic and blood gas changes of this model.

目的 复制四氧化二氮（ N 2 O 4 ）和偏二甲基肼染毒与冲击波致冲毒复合伤大鼠模型，并研究其对 Wistar 大鼠血气及病理形态学的变化。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。