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Then one day, destiny just walks up|and taps you on the shoulder.

突然有一天|命运的手轻拍我的肩膀

Good lord—it's as plain as the nose on your face; his girl friend has jilted him.

天哪,难道这还不清楚吗?他的女朋友把他甩了。

The activation of endothelial cell caused by TNF-α has detrimental effects on the vasculature. TNF-α can induce the increased apoptosis of gravid trophocyte. TNF-α has been showing up-regulate the vasoconstriction factors such as endothelin and down-regulate the vascular relaxing factors such as NO on the contrary.

肿瘤坏死因子α作为炎性分子,激活血管内皮细胞、间接影响血管舒缩功能,通过各种机制诱导胎盘滋养细胞凋亡增加,增加血管收缩因子并减少血管舒张因子的生成和释放,影响与脂类代谢相关的细胞因子。