多骨的

Kanzawa pointed, the abdominal vertebra BMD of PTH gene individuals in BB genetype is obviously higher than those of Bb and bb genetype,so he considered that the BstBI polymorphism of PTH gene has dependability with BMD while the DraⅡpolymorphism of PTH gene has no dependablity with BMD.3 The polymorphism of estrogen receptor gene and postmenopausal osteoporosisPMOP is a metabolic bone disease existing in post-menopause femmes, as a result of these femmes\' hypofunction of ovary,ESG level drawdown and the disequilibrium of bone couple procedure,the bone resorption of osteoclast exceeds the bone formation of osteoblastic,osteopenia and bone fragility accrescence have developed,then induces fracture and so on.

Kanzawa等研究发现，BB型PTH基因人的腰椎BMD较Bb、bb型显著为高，认为PTH基因BstBⅠ多态性与BMD有相关性；但PTH基因DraⅡ多态性则与BMD无相关性。三雌激素受体基因多态性与绝经后骨质疏松绝经后骨质疏松是指绝经后妇女由于体内卵巢功能低下，雌激素水平低落，骨偶联过程失衡，破骨细胞的骨吸收大于成骨细胞的骨形成作用所导致的骨量减少，骨脆性增加，进而易于发生骨折的代谢性骨疾病。

Sitting in a pool of shadow upon a throne made from the fused bones of his victims, a carpet of still-screaming faces leading up to gnarled, naked feet, sits Night Haunter himself.

在一个充满黑暗的远离王座和他受害者的骨块的池子当中，一块充满尖叫的脸孔的地毯吸引着暗杀者的目光看到了一双多瘤的而赤裸的下肢，暗夜幽魂正端坐在那。

All iliac hone graft fused well and a great deal of bony callus was found the vertebral body surface. Lucency area was in seen surrounding the hone graft, titanium and AC-AFF on the X-ray films, and there wan new bone formation in the interface of internal union and bone. The central region of titanium and AC-AFF became vague and new bone formation was found in the intracavitary aim of implants by CT scan. And port of the new hone transited the parietal reticulation and connected with normal ones at titanium and AC-AFF.

髂骨植骨组融合情况良好，融合界面上有较多的骨痂生成。X线摄片见植骨块、钛网、AC-AFF中空区域模糊且有骨组织生长，内植物周围无透光带存在，植骨界面上有骨桥形成；CT扫描在钛网及AC-AFF组可见内植物腔内形成的新骨通过其四壁的网眼结构与周围骨质相接，说明所有标本均达到骨性融合，但其中以AC-AFF组形成的新骨数量为多，且较为成熟。

Results: At the concentrations of 0.1, 1 and 10 μmol/L, berberine dose-dependently suppressed the formation of TRAP-positive multinucleated cells, the TRAP activity and the osteoclastic bone resorption. The strongest inhibitory effect was exhibited at the concentration of 10 μmol/L, with the inhibiting rate of 60.45%, 42.12% and 72.69% respectively.

结果：小檗碱在0.1~10μmol/L范围内，浓度依赖性地抑制TRAP阳性多核破骨细胞的形成和TRAP活性，减少破骨性骨吸收陷窝的面积；在10μmol/L浓度下，对破骨细胞的抑制作用最强，对TRAP阳性多核破骨细胞的形成和TRAP活性的抑制率分别达到了60.45%和42.12%，骨吸收陷窝面积减少72.69%。

Results:(1) FSN can inhibit secondary joints swelling and multi-arthritis evidently, improve the whole condition of rats; at the same time, it can also lighten the synovial inflammation and hyperplasia of lesion joints distinctly, and prevent the joint cartilage and bone from destruction; the collective efficiency of FSN is better than TWP.(2) FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th / Ts and Thl / Th2 cells balance in peripheral blood, restrain exorbitant TNF- a ? IL-1 produced by PM O , thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF- a mRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflamination and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue,reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage.Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果：(1)FSN有明显的抗炎作用，可显著抑制AA大鼠足跖肿胀与多关节炎，改善大鼠的全身情况，同时明显减轻病变关节滑膜炎症与增生，防止关节软骨及骨质的破坏，其综合作用优于TWP；(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常，纠正外周血中T细胞亚群Th／Ts及Th1／Th2平衡紊乱，抑制大鼠PHφ过高的TNF-α、IL-1分泌，而发挥抗炎和免疫调节作用；(3)在病变关节局部，FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达，降低滑膜组织中NF-kB表达，并增加凋亡蛋白酶Caspase-3表达，从而抑制滑膜的炎症与增殖；(4)FSN还可下调滑膜组织中VEGF表达，减少血管新生，由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀；(5)FSN的上述作用皆呈现一定的量效依赖关系，高剂量组作用优于低剂量组。

FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th/Ts and Th1/Th2 cells balance in peripheral blood, restrain exorbitant TNF-α、IL-1 produced by PMφ, thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF-αmRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflammation and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue, reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage. Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果：(1)FSN有明显的抗炎作用，可显著抑制AA大鼠足跖肿胀与多关节炎，改善大鼠的全身情况，同时明显减轻病变关节滑膜炎症与增生，防止关节软骨及骨质的破坏，其综合作用优于TWP；(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常，纠正外周血中T细胞亚群Th/Ts及Th1/Th2平衡紊乱，抑制大鼠PMφ过高的TNF-α、IL-1分泌，而发挥抗炎和免疫调节作用；(3)在病变关节局部，FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达，降低滑膜组织中NF-kB表达，并增加凋亡蛋白酶Caspase-3表达，从而抑制滑膜的炎症与增殖；(4)FSN还可下调滑膜组织中VEGF表达，减少血管新生，由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀；(5)FSN的上述作用皆呈现一定的量效依赖关系，高剂量组作用优于低剂量组。

The periostea of both experimental and control side of the mandibular ramus were taken and prepared, 2 of each 5 rabbits in a group were prepared for HE stain detection and 3 for proliferating cell nuclear antigen immunohistochemical detection.Results:1, The newly formed bone was detected on the lateral aspect of mandibular ramus after periosteal distraction. The bone was shaped like a hill. It looked very low and was full of holes at postoperative day 28. With the time of consolidation period lengthened, the newly formed bone matured gradually. X-ray examination showed the new bone shaped like a hill. The average values of new bone height at postoperative days 28,35,42 and 56 were 1.86 + 0.15mm, 2.29 + 0.29mm,3.19 + 0.13mm and 4.70 + 0.45mm. Histological examination of both HE stain and picricacid-fuchsin stain showed the increase in the number of osteoblasts and the change in the orientation of collagen fibers and bone trabecula. There were no significant differences between newly formed bone and original bone on the lateral aspect of mandibular ramus at postoperative day 56 histologically.2 Compared with the control side, the distracted periostea proliferated obviously under the microscope, and the number of periostealcells increased with satiation of cellular nuclear per unit area. The images of PCNA immunohistochemical stain of periosteum showed that the experimental periosteum proliferated obviously after distraction compared with the control side.

结果：骨膜牵张成骨的实验研究南京医科大学硕{学位论文l、骨膜牵张后，可见下领升支外侧的骨皮质上有新骨形成，新骨呈山峰状凸起，术后第28天的新生骨较低平，多孔隙，随着固定时间的延长，新骨逐渐成熟；下领升支前后向切线位X线投照显示新骨呈山峰样隆起；经测量，术后第28、35、42和56天组平均新生骨厚度分别为x.86士0.15mm、2.29士0.29mm、3.19士0.13mm和4.70 土0.45mm；脱钙骨组织的HE染色和不脱钙骨组织的苦味酸一品红染色的组织学观察均显示了新生骨在成骨细胞数量上的增长，以及胶原纤维和骨小梁排列方向上的变化，术后第56天的新生骨在组织学上与原升支骨组织已无明显区别。2、HE染色显示，与对照组相比较，实验侧骨膜增生明显，细胞间排列紧密，单位面积内骨膜细胞数增多，细胞核饱满；骨膜PCNA 免疫组化染色显示，与对照侧相比较，实验侧骨膜在牵张后出现了明显的增生迹象，PCNA阳性细胞分布紧密，单位面积内阳性细胞数较对照组多，靠近骨表面的骨膜中的阳性细胞数更多而且分布更为紧密。

Result:①out of 25 patients,17 exhibited myeloma-related bone lesions on radionuclide imaging,the positive rate was 68.0%,ribs and spine were involved most frequently,162 lesions showed high uptake of radionuclide,the lesions lied in ribs appeared as strings of pearls,and those in sternums and vertebrae showed linear high uptake,the other 4 showed decreased radionuclide uptake.②the positive rate on radiography was 68.0%(17/25),which was the same as that on radionuclide imaging,the patterns were osteoporosis,pathological fracture,osteolysis or two or two and above of these appearances, radiography detected more abnormalities than radionuclide imaging in identical sites(162 versus 144),but radionuclide imaging detected more lesions than radiography in ribs and sternums.

结果：①25例患者中，骨显像异常17例，阳性率68.0%，肋骨、脊柱最常受累，162处病灶表现为异常放射性聚集，其中，肋骨病灶呈串珠样，胸骨及椎体病变呈扁平状或线状，4处表现为异常放射性减低；②x线片阳性率68.0%（17/25例），与骨显像相同，主要表现为骨质疏松、病理性骨折、骨破坏或呈混合性改变，共同检测的部位中，x线片检出的病灶总数较骨显像多（162和144），但骨显像检出肋骨和胸骨病灶较x线片多。

The positive rate on radiography was 68.0%(17/25),which was the same as that on radionuclide imaging,the patterns were osteoporosis,pathological fracture,osteolysis or two or two and above of these appearances, radiography detected more abnormalities than radionuclide imaging in identical sites(162 versus 144),but radionuclide imaging detected more lesions than radiography in ribs and sternums.

结果：①25例患者中，骨显像异常17例，阳性率68.0%，肋骨、脊柱最常受累，162处病灶表现为异常放射性聚集，其中，肋骨病灶呈串珠样，胸骨及椎体病变呈扁平状或线状，4处表现为异常放射性减低；②X线片阳性率68.0%（17/25例），与骨显像相同，主要表现为骨质疏松、病理性骨折、骨破坏或呈混合性改变，共同检测的部位中，X线片检出的病灶总数较骨显像多（162和144），但骨显像检出肋骨和胸骨病灶较X线片多。

Advanced imaging workstation and big capacity computer also were applied to make the 3D reconstruction of ear ossicles ,labyrinth ,cochlear, nerve , tumour, blood vessel et al in order to prepare for imitating operation.

作者还应用新型的多层螺旋CT，对颞骨的表面结构进行了重建观察，重建立体图像资料的数据与解剖标本数据进行了对照，以印证三维成像测量数据的可靠性。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。