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Alpha-1 antitrypsin is the most abundant circulating protease inhibitor in the body, Dr. Lomas said. Its most common deficiency mutation is the Z allele, where the amino acid lysine is exchanged for glutamic acid at position 342 in the polypeptide chain (Glu342Lys). About 1 in 1700 whites of northern European descent are homozygotes for this mutation and thus have plasma antitrypsin levels that are 10% to 15% below normal, he said.

Lomas博士表示,甲一型抗胰蛋白酵素是身体内最充分的循环蛋白酶抑制剂,最常见的缺损突变在Z对偶基因,该处的胺基酸 lysine与麸氨酸在多胜肽链的第342位置交换(Glu342Lys);北欧血统白人每1,700人有1人是此一突变的同合子,因此血浆抗胰蛋白酵素值比正常低10%到15%。

Furthermore, the ability of betulinic acid to induce apoptosis in melanoma and other cell types and the favoral therapeutic index suggests that betulinic acid is an attractive and promising antitumor agent.

虽然白桦酯酸存在于很多植物种类中,但其普遍含量很低,由于其巨大的研究价值,仅靠植物提取已经不能满足越来越多的研究需求,与白桦酯酸结构很相近的化合物白桦酯醇,在白桦树皮中含量高于10%,而白桦又是北半球数量丰富的树种。

Compared with the traditional two-phase anaerobic process, there are more microbe populations in the hydrolytic acidification reactors or anaerobic reactors than those in the single phase, the combined anaerobic reactors appeared more stable, and the bionomic condition would be easily realized.

与两相厌氧工艺相比,复合厌氧法中,水解酸化反应器和厌氧反应器中的菌群种类要比单一的产酸相或甲烷相中的多,所构成的微生态系统更为稳定,所需要的生态条件比较容易实现。

The metabolites were mainly aldehydes and acids when the level of inoculation was 10~9cfu/ml, however, alcohols, acids and esters were produced when the level of inoculation was 10~8cfu/ml. The optimal temperature and pH for production of 3-methyl butanal were 40℃ and 7.0, but NaCl and NaNO_2 inhibited its production.

接种量不同会导致代谢BCAA的产物不同:接种量为10~9 cfu/ml时生成相应的醛和酸;接种量为10~8 cfu/ml时生成相应的醇、酸和酯。S52菌株在40℃,pH 7.0,无亚硝酸盐和NaCl的情况下产3-甲基丁醛的量最多。

Photoinduced Electron Transfer [2+2] Cycloaddition Reactions ofBenzannelated Isoquinolin-1-ones with Electron Deficient Alkenes Photoinduced [2+2] cycloaddition reactions of 11H-benzoxazolo[3,2-b]isoquinolin-11-one 8 and 11H-benzothiazolo[3,2-b]isoquinolin-11-one 13 with electron deficient alkenessuch as acrylonitrile, methyl acrylate, dimethyl fumarate and dimethyl maleate afforded a group of polycyclic isoquinoline derivatives bearing cyclobutane moieties ingood to excellent yields and resulted in the Schenck isomerization of the alkenes.

3苯并增环异喹啉-1-酮与缺电子烯烃的光诱导电子转移[2+2]环加成反应 11H-苯并恶唑[3,2-b]异喹啉-11-酮8和11H-苯并噻唑[3,2-b]异喹啉-11-酮13与缺电子烯烃如丙烯腈,丙烯酸甲酯,富马酸二甲酯及马来酸二甲酯的光诱导[2+2]环加成反应以高产率给出一系列含有环丁烷结构单元的多环异喹啉衍生物并导致烯烃的Schenck异构化作用。

In order to further understand combining characteristic of cyclohexyl methylphosphonofluoridate and isopropyl methylphosphonofluoridate and contribute more scientific data for its medical protection, the potency of inhibition of acetylcholinesterase activity induced by GF, GF+GB and the effects of reactivation by oximes pyramidoxime monohydrate(HI-6) and pyridine-2-aldoxime methylchloride(2-PAM-Cl) in rat brain were investigated with DTNB microanalysis in this study.

为进一步了解甲氟膦酸环己酯与甲氟膦酸异丙酯的联合特性,为制订医学防护措施提供更多的理论依据,用微量DTNB法对GF,GB和GF与GB混合对大鼠脑乙酰胆碱酯酶的抑制及肟类重活化剂酰胺磷定(HI-6)和氯磷定(2-PAM-Cl)的重活化作用进行了研究。

All the complex series based on 4',4''-dicarboxy-1,6-diphenoxyhex- ane (C6-2COOH) and 4',4''-dicarboxy-1,10-diphenoxydecane (C10-2COOH) possessed higher melting and clearing points, usually showed soft crystal or crystalline smectic phases and crystal polymorphs except C10-2COOH/ p -PhBPy complex displaying also an enantiotropic nematic phase, while the complexes based on 4,4'-dicarboxy-α,ω-diphenoxy tetraethyleneglycol ether (C8O4-2COOH) with a longer flexible spacer exhibited monotropic fluidic smectic SmA and/or nematic phases.

研究表明,分别具有较短的6或10个亚甲基的烷烃间隔基的双苯甲酸衍生物4',4''-二羧酸-1,6-二酚氧基己烷(C6-2COOH)和4',4''-二羧酸-1,10-二酚氧基癸烷(C10-2COOH)的系列复合物具有较高的熔点和清亮点,一般都只出现结晶近晶相和多晶型转变现象。

The way to prepare iodomethane using methanol, potassium iodine and acid as regents has the disadvantages such as many side reactions and low yield, while the synthesize route from dimethyl sulfate and potassium iodine has the advantages of high yield and simple separation.

醇与氢卤酸作用是制备卤代烃的常用方法,以甲醇为试剂,以碘化钾与酸作用生成氢碘酸制备碘甲烷的方法存在副反应多、收率不高的特点;而以硫酸二甲酯及碘化钾为试剂的合成路线具有操作容易、收率高、纯化简单的优点。

In this study,the changes of phenolic compounds ,phenylalanine ammonia-lyase,peroxidase and polyphenol oxidase activities during malting(including steeping,germination and kilning) with three domestic barley varieties were investigated,and the relationships between changes of phenolic content and enzyme activities and malting technics were analysed.

研究了3种典型国产啤酒大麦在麦芽制造过程中酚类物质及其相关酶类(苯丙氨酸解氨酶:phenylalanine ammonia-lyase,PAL、过氧化物酶:peroxidase,POD和多酚氧化酶:polyphenol oxidase,PPO)的变化,分析了制麦过程中酚类物质含量的变化与酶活力和制麦工艺之间的关系,讨论了大麦发芽过程中苯丙氨酸解氨酶在合成酚类物质方面的作用及过氧化物酶对根芽生长和制麦损失的影响。

Phenolic compounds and related enzymes in barley influence its growth and brewing processes.In this study,the changes of phenolic compounds,phenylalanine ammonia-lyase,peroxidase and polyphenol oxidase activities during malting(including steeping,germination and kilning) with three domestic barley varieties were investigated,and the relationships between changes of phenolic content and enzyme activities and malting technics were analysed.The functions of PAL on biosynthesis of phenolic compou...

研究了3种典型国产啤酒大麦在麦芽制造过程中酚类物质及其相关酶类(苯丙氨酸解氨酶:phenylalanine ammonia-lyase,PAL、过氧化物酶:peroxidase,POD和多酚氧化酶:polyphenol oxidase,PPO)的变化,分析了制麦过程中酚类物质含量的变化与酶活力和制麦工艺之间的关系,讨论了大麦发芽过程中苯丙氨酸解氨酶在合成酚类物质方面的作用及过氧化物酶对根芽生长和制麦损失的影响。

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