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METHODS: Three different MBP peptides(MBP6886, 8799, and the nonencephalitogenic peptide 110128) were synthesized and administrated nasally to Lewis rat on day11, 10, 9, 8 and 7 prior to immunization with the guinea pig MBP CFA, which was used to induce EAE.

合成3条不同的碱性髓鞘蛋白多肽(MBP6886、 8799和非致脑炎性肽段110128),在用豚鼠MBP加弗氏完全佐剂免疫Lewis大鼠前的11、 10、 9、 8和7 d,经鼻黏膜分别给予MBP多肽,观察其对EAE的保护作用。

METHODS: Three different MBP peptides(MBP6886, 8799, and the nonencephalitogenic peptide 110128) were synthesized and administrated nasally to Lewis rat on day11, 10, 9, 8 and 7 prior to immunization with the guinea pig MBP + CFA, which was used to induce EAE. The protective effect on Lewis rat from EAE by the MBP peptides was evaluated.

合成3条不同的碱性髓鞘蛋白多肽(MBP6886、 8799和非致脑炎性肽段110128),在用豚鼠MBP加弗氏完全佐剂免疫Lewis大鼠前的11、 10、 9、 8和7 d,经鼻黏膜分别给予MBP多肽,观察其对EAE的保护作用。

The releasing pattern of secretory granules or polypeptide hormones of neurohypophysis involves a whole-releasing pattern together with granular membrane. After released into perivascular space, they enter easily into cerebrospinal fluid via interspace of tissue and epithelial openings rather than into blood circulation through the walls of capillaries, and then into the cerebrospinal fluid.

神经垂体多肽激素分泌颗粒的释放形式,存在一种连同颗粒被膜的整体释放;释放入血管周隙内的多肽激素或分泌颗粒,更易经组织间隙、囊上皮孔进入脑脊液,而非直接透过毛细血管壁进入血液循环再进入脑脊液中。

In order to facilitate NO- to combine with the heme iron ion so as to improve the stability of pigment, this experiment utilized protease to hydrolyze Hb to some degree and then made NO- react with Heme-iron to concatenate large molecule polypeptide, into nitrosyl heme-polypeptide .

为了使亚硝基更易结合于血红素亚铁离子及提高色素稳定性,本研究采用蛋白酶有限酶解猪血红蛋白,酶解液中大分子血红素多肽与亚硝基反应合成亚硝基血红素多肽

In order to facilitate NO- to combine with the heme iron ion so as to improve the stability of pigment, this experiment utilized protease to hydrolyze Hb to some degree and then made NO- react with Heme-iron to concatenate large molecule polypeptide, into nitrosyl heme-polypeptide.

摘 要:为了使亚硝基更易结合于血红素亚铁离子及提高色素稳定性,本研究采用蛋白酶有限酶解猪血红蛋白,酶解液中大分子血红素多肽与亚硝基反应合成亚硝基血红素多肽

In order to facilitate NO- combine with the iron ion of Heme and to improve the stability of pigment, this experiment utilize protease to hydrolysate Hb to some extent and then NO- interact with Heme-iron concatenated large molecule polypeptide, nitrosyl heme-polypeptide being synthesized.

为了使亚硝基更易结合于血红素亚铁离子及提高色素稳定性,采用蛋白酶有限酶解猪血红蛋白,酶解液中大分子血红素多肽与亚硝基反应合成亚硝基血红素多肽

The studies show that Amyloid β-peptides aggregate and accumulate, moreover, colocalize with numerous other associated protein and nonprotein components to form SPs. There are many factors to induce the Aβ aggregation.

研究表明是淀粉样Aβ多肽逐渐聚集、纤维化并与其它相关蛋白质、聚糖等共沉淀形成了脑斑,诱导Aβ多肽凝聚的可能因素很多,本文着重探讨了锌离子的诱导机理。

But for industrial production of polypeptides, it is particularly important of its separation and purification techniques or mass production. It is significant to study these parathion and analyses of polypeptides so as to contribute to industrialization.

而对于多肽物质的工业化生产来说,多肽物质的分离纯化、大量制备就显得格外重要,它的分离与分析技术是生物技术实现产业化的关键。

In the development, the synthesis of 17.5×103 polypeptide was almost undetectable at first.

在这5种多肽中,17.5 ×103 多肽的甲硫氨酸含量最高。

Secondary structure In a PROTEIN, the basic shape of the polypeptide, i.e. the way it folds.

二级结构:是蛋白质中多肽的基本构像,即多肽折叠的方式。

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