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It is caused by the degeneration of nigro-striatum dopaminergic neuron resulting in the reduction of dopamine and the hyperfunction of acetylcholine.

帕金森病(Parkinson's disease,PD)为神经系统变性疾病,主要的病理改变是黑质纹状体通路的多巴胺能神经元变性,导致多巴胺减少和乙酰胆碱系统功能亢进。

Parkinson's disease is a common neurodegenerative disease, which mainly affect the old age, characterized by tremor, muscle rigidity, bradykinesia and postural instability. It is caused by the degeneration of nigro-striatum dopaminergic neuron resulting in the reduction of dopamine and the hyperfunction of acetylcholine.

帕金森病(Parkinson's disease,PD)为神经系统变性疾病,主要的病理改变是黑质纹状体通路的多巴胺能神经元变性,导致多巴胺减少和乙酰胆碱系统功能亢进。

There is increasing evidence that, in addition to its function as the main neurotransmitter in the nigrostriatal pathway, dopamine may be neurotoxic in certain conditions.

越来越多的证据表明:多巴胺除在黑质纹状体通路作为主要的神经递质之外,在某些情况下可能具有神经毒性。

Finally, we present an arithmetic of multiplehypocentral, heterogenous dislocation, and a multirupture segment superposition model for simulating the earthquake deformation field. The simulated LOS interferometry map presents the distribution characteristics of the earthquake deformation field better than that of previous studied. Meanwhile, a suit of fault geometric parameters of the earthquake is also obtained by the study. Having a better effect upon simulating asymmetry, great dislocation, macro rupture field, and nonhomogeneity of dislocation than the traditional model, the multisegment method is a progress of this work. It provides a better explanation for the study on hypocentral parameters.

基于上述原因,本文对Okada线弹性位错模型的算法进行了改进,提出了"多震源、非均一位错分量、多破裂段叠加"的线弹性模型,该模型模拟出的形变场干涉纹图较好地体现了地震形变场的分布特征,并由此获得了一套较为完整的地震发震断层的几何学特征参数,为破裂带长度、破裂面方向、破裂面大小等震源破裂特征参数研究提供了较好的解释。

In present study, we demonstrated that μ opioid receptor and D1 dopamine receptor could form heteromeric complexes in membranes preparation from HEK293T cells transiently cotransfected with both receptors and from mice striatum.

在本工作中,我们通过免疫共沉淀和BRET法证明,HEK293T细胞上瞬时表达的μ阿片受体和D1多巴胺受体能形成异源二聚体,并证实μ阿片受体和D1多巴胺受体异源二聚体存在于小鼠纹状体中。

In present study, levels of dopamine 〓 and 〓 receptors and expression of the protein mRNAs in striatum were exarmined by the methods of immuno- histochemistry and in situ hybridization, respectively. It was found that mice treated by paraquat taken orally for four months displayed a marked hypoactive behavior.

本研究以口服给予小鼠百草枯的PD模型,采用免疫组织化学、原位杂交结合计算机图像处理分析技术,观察百草枯对纹状体区多巴胺〓受体、多巴胺〓受体蛋白含量和基因表达的影响。

The carotid bifurcation on 8 sides had perforating arteries, and I l sides showed medial lenticulostriate artery of the middle cerebral arteries, with short course and overlapped with another perforating arteries upon entry into the anterior perforated substance.

豆纹动脉绝大部分从大脑中动脉M1段的分叉前段发出,但是大脑中动脉M1段的分叉越早,分叉后发出的穿通动脉越多。22侧半球存在大脑前动脉A1段的穿通动脉,进入前穿质时分支较多。

In experimental animals, exposure to a common herbicide, rotenone, induces features of Parkinsonism; mechanistically, rotenone-induced destruction of dopaminergic neurons has been attributed to its inhibition of the activity of neuronal mitochondrial complex Ⅰ.

例如,Greenamyre和他的同事在2000年报道了经大鼠颈静脉慢性灌流鱼藤酮复制了帕金森病的主要特征,包括选择性黑质纹状体多巴胺系统变性,Lewy小体样细胞浆包涵体形成和一些行为变化,例如运动减少和僵直等。从发病机制上考虑,鱼藤酮诱导的多巴胺神经通路损伤被认为是由鱼藤酮抑制线粒体复合体Ⅰ活性引起的。

After neurotoxin treatment, CR monkeys exhibited significantly higher levels of locomotor activity compared with control monkeys as well as higher levels of dopamine and DA metabolites in the striatal region.

神经毒素处理以后,热限制的猴子与对照组的猴子相比表现出更高的自发活动能力,并且多巴胺和多巴胺代谢产物在纹状体也表现出非常高的水平。

The susceptibilities of the 3th instar larvae of Spodoptera litura fed on diets treated with nicotine and rutin to AucaNPV, fipronil and spinosad were studied. The activities of CarE and GSTs in different treated cutworms were also tested. The results showed that the nicotine enhanced significantly the susceptibility of Spodoptera litura to insecticides, and the susceptibility enhanced as the nicotine concentration in the diets increased.

以在人工饲料中添加植物次生物质的方法,研究了取食不同含量烟碱、芸香苷的斜纹夜蛾Spodoptera litura 3龄幼虫对银纹夜蛾核多角体病毒、氟虫腈及多杀菌素的敏感性,同时测定了各处理组幼虫体内羧酸酯酶和谷胱甘肽转移酶的活性。

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On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面,更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值,分为几个相等的区间作为横轴,并将各区间内所测定值依所出现的次数累积而成的面积,用柱子排起来的图形,也叫做柱状图。

You rap, you know we are not so good at rapping, huh?

你唱吧,你也知道我们并不那么擅长说唱,对吧?