多种免疫

In a very long incubation period, infected Although there is no subjective symptoms, appearance, as ordinary people, but systemic immune system by the AIDS virus continues to damage to the immune system can no longer maintain the minimum defense capability, a variety of normal will not cause disease pathogenic microorganisms would make the conditions of patients with infection caused brain, lungs, gastrointestinal tract and other parts of the lesions and symptoms.

在很长的潜伏期中，感染者虽然没有自觉症状，外表一如常人，但全身免疫系统仍在继续受到艾滋病病毒的破坏，到免疫系统功能再也不能维持最低的防御能力时，多种对正常人不会引起疾病的病原微生物便会使患者发生条件性感染，引起脑、肺、胃肠道和其他部位的病变及症状。

The Nature of Antibodies and the Immune Response in Rainbow Trout.

抗体是由抗原免疫后产生的，与某一抗原专一性地结合，特异性程度高；而凝集素是天然存在的，不需经过免疫而产生，能与多种抗原发生凝集反应，具有非特异性。

Objective To study the antigenpresenting function of splenic dendritic cells in mice after hemorrhage plus closed fracture.Methods Splenic DCs were isolated 24h after hemorrhage plus closed fracture,then the ability to stimulate nonadherent splenocytes proliferation in the presence of conalbumin in vitro was detected,IL12 and IL10 levels in cell supernatants were measured by ELISA kits.

大量研究表明，创伤能引起机体免疫系统产生复杂的变化，树突状细胞(dendritic cells，DC)是体内功能最强的专职抗原递呈细胞(antigenpresenting cells，APC)，它可摄取和加工抗原，并分泌多种细胞因子，在激发T 细胞的免疫应答中起重要作用。

Objective To study the antigenpresenting function of splenic dendritic cells in mice after hemorrhage plus closed fracture.Methods Splenic DCs were isolated 24h after hemorrhage plus closed fracture,then the ability to stimulate nonadherent splenocytes proliferation in the presence of conalbumin in vitro was detected,IL12 and IL10 levels in cell supernatants were measured by ELISA kits.

大量切磋证明，创伤能引起机体免疫编制发生庞杂的改变，树突状细胞(dendritic cells，DC)是体内效用最强的专职抗原递呈细胞(antigenpresenting cells，APC)，它可摄取和加工抗原，并渗透多种细胞因子，在激励T 细胞的免疫应答中起重要作用。

Secreted by the epithetical cells of animal thymus, Ta1 is widely distributed. It is an immunoregulatory peptide with multiple biological activities such as modulate cell-mediated immunity, anti-aging and anti- virus activity and so on.

它由动物胸腺上皮细胞分泌，在体内分布广泛，是一具有多种生物学活性的免疫调节剂，可调节细胞免疫功能，有较好的抗衰老和抗病毒作用等。

Increase the bone marrow cell component while reduce the fat component, abnormal the caryon and cytomembrane structure of bone marrow cell and stromal cell, enrich the ribose body, mitochondrion and rough surfaced endoplasmic reticulum in cytoplasm of several organs and tissues, embody abvious improvement of heart muscle, liver, immnune organs, incretory organs and sexual gland.

增加免疫介导型再障小鼠的骨髓细胞成分，减少脂肪成分。使骨髓细胞和基质细胞的细胞核和细胞膜结构趋于正常，使多种脏器组织的细胞浆内核糖体丰富，线粒体及粗面内质网发达。对心、肝、免疫器官、内分泌器官及性腺等亦有明显的改善作用。

Changes in IL-2/IL-2R system in 25 patients with thyrotoxic Graves disease and 20 eu-thyroids were investigated and compared with those of 15 normal controls. The thyrotoxic patients showed a high concentration of serum sIL-2R and a large amount of circulating IL-2R-α- cells but a decreased production of IL-2 by PBMC. However, these abnormalities had a tendency to become normal with improvement of the disease.

Graves病的发生是环境、遗传和免疫等多种因素综合作用的结果＊淋巴细胞的免疫调节异常是其中的一个重要原因，而白细胞介素-2（IL-2）及其受体在维持正常T细胞功能和兔疫调节方面发挥关键作用。

The findings of the newly identified goose paramyxovirus strain GPMV/HBexperimental infection were as follows: The challenge caused high morbidity and highmortality.The clinical signs included severe depression, decreased appetite or anorexia,white,yellow and green diarrhea, with neural symptoms;pathological changes showed thathaemorrhage and ulceration of intestine mucosa, necrosis of spleen and pancreas,andedema of liver and kidney, uratic deposition in kidney.Eosinophilic inclusion bodies werefound in the cytoplasm of pancreas and a large quantities of fiber protein were found inintestine. Lots of hemosidefin was found in some area of liver and kidney. A number ofT、B lymphocytes reduced sharply in spleen,lymph nodes in dead geese. Transmissionalelectron microscope showed that some cells had the morphological characteristics ofmitochondria swelling, morphological changes were condensation of nuclear chromatininto dense masses,followed by its marginating against the nuclear envelope, andespecially concentration of cytoplasm association with lots of lipid droplet.

人工感染雏鹅实验中，雏鹅临床表现为高发病率和高死亡率，食欲和饮水减少，拉白色、黄绿色稀粪，伴有神经症状；常规组织学观察，脾脏和胰腺肿大，有白色坏死斑点，肠道出血和坏死，肝脏肿大变性，肾脏肿大变性有尿酸盐沉着等；用特殊染色和组织化学方法首次对人工感染鹅副粘病毒的雏鹅的重要脏器进行研究，结果表明：胰腺中发现病毒包涵体，肠道中大量纤维素以及胶原纤维增生，肾脏、肺脏大量含铁血黄素沉着，免疫器官如脾脏和淋巴结中T、B淋巴细胞大量减少；电镜下多种细胞呈现线粒体水肿，多种实质细胞的染色质固缩，染色质边集，特别是细胞内容物如脂肪滴增多的病理变化特征。

The Food and Drug Administration of USA hasapproved the use of this topical medicine for treatment of different malignant andpremalignant tumors such as actinic keratoses and basal cell carcinoma. Althoughimiquimods exact mechanisms of action in neoplastic diseases has not yet been fullyelucidated, animal and human studies have shown its ability to enhance the productionof cytokines such as interferon-, interleukin-12, and tumor necrosis factor- though conjugations with Toll like receptors on the surface of dendriticcells of the monocyte-macrophage lineage.

有关咪喹莫特抗癌作用的具体机制仍不十分明了，一般认为，咪喹莫特主要是通过与免疫相关细胞表面的Toll样受体结合、促进IFN-α、TNF-α、IL-12等多种前炎症细胞因子的分泌，进而激活天然与获得性免疫反应的方式发挥抗癌作用；进一步的研究发现，咪喹莫特尚能选择性的抑制某些皮肤肿瘤细胞的增殖并诱导其凋亡，提示增殖抑制和诱导凋亡可能是评价咪喹莫特抗肿瘤作用的重要指标和机制。

The immune defect in uremic patients include humoral and cellular. Especially the cellular defect will influence vaccination of hepatitis B vaccine and the same on other T-cell dependent vaccines include pneumococci and Haemophilus influenzae.

尿毒症病人的免疫不全包含体液性与细胞性以及其他多种层面，尤其在细胞性缺陷上更是直接影响B型肝炎疫苗的免疫效果，以及其他T细胞依赖性疫苗(T-cell dependent vaccines)，例如：肺炎球菌疫苗、流行性感冒疫苗等。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。