多种免疫

When HIV-1 in culture medium was exposed to a range of concentrations of urokinase, a dose-dependent inhibition of infectivity was observed in a variety of lymphoma and leukemia cell lines including MT4, CEM, H9, and peripheral blood mononuclear cells using assays for reverse transcriptase, P24 antigen and syncytia formation.

通过检测逆转录酶活力，P24抗原的表达和合胞体形成情况发现尿激酶可以抑制人体免疫缺损病毒对多种淋巴瘤和白血病细胞系，如MT4、CEM、H9和外周血单核细胞的侵染能力，并且这种抑制与尿激酶浓度呈剂量依赖关系。

In the present paper, the Sox gene expression analysis of different tissues from the Trionyx sinensis was studied by using RTPCR, and Sox gene fragments of expression from the testicle, brain and spleen were cloned using RTPCR products. The results show that Sox gene has specific expression in the testicle, brain, spleen, cardiac muscle and kindney and hasn't expression in muscle, liver and ovary. The results of clone reveal that the Sox genes of expression in the testicle are TSSox1 and TSSox 4, and those are TSSox2 and TSSox4 in the brain, and that is TSSox4 in the spleen. This suggests that the Sox gene act important role not only on the sex determination, but also on the development of neural system, immunocyte system and the differentiattion of male germ cell.

本文采用RT—PCR技术，研究了中华鳖不同组织Sox基因的表达，并通过PCR直接克隆法，分析了来自睾丸、脑和脾组织中的Sox基因序列结果表明在中华鳖的成体组织中，Sox基因在脑、心肌、肾、脾和雄性的睾丸组织中均有不同程度的表达，而在肌肉、肝脏和雌性的卵巢中则无表达，显示该基因具有组织表达特异性克隆分析显示，在睾丸组织中表达的是TSSox1和TSSox4基因，而在脑组织中表达的是TSSox2和TSSox4基因，脾组织中表达的是TSSox4基因此结果表明Sox基因不仅在性别决定中起作用，还可能在神经系统、免疫系统多种组织中起重要作用

Systemic lupus erythematosus is an autoimmune disease, which involved many organs and is characterized by generation of vari...

系统性红斑狼疮是多器官受累的自身免疫性疾病，以产生多种自身抗体并形成相应的免疫损伤为特征，但驱动自身抗体生成的启动原至今未明。

One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活，ICAM-1表达升高，与被激活的PMN表面表达的LFA-1相结合，&PMN-EC&相互作用加剧，一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍；另一方面粘附的PMN过度吞噬或激活，当白细胞吞噬的颗粒不能被封闭隔离，连同细胞内的酶被释放出来，其中的PMN-elastase能够降解细胞基质中各种成分，水解多种蛋白，加重胰腺的毛细血管内皮细胞和腺泡的损伤；释放的溶酶体酶使组织蛋白水解，产生的不饱和脂肪酸引发脂质过氧化方应，破坏细胞膜的结构和功能；释放的炎性细胞因子，激发其他的免疫细胞的功能，导致进一步的组织损伤和坏死，加重SAP的病理损伤，最终导致休克、脓毒血症及多器官功能障碍等严重后果。

Using biochemical markers, microcytotoxicity test and Ouchterlony methods, the genetic character of 156 wild mice from 6 sites in 4 zoogeographical regions of China were investigated, and comparison with 8 strains of laboratory mouse were studied by authors.

本文用同工酶电泳法、微量细胞毒法和免疫双向扩散法对我国4个动物地理区的6个采集点的156个小家鼠进行了遗传特性的调查。结果发现：在全部被测的13个位点中，小家鼠在7个位点上存在着多种实验小鼠中罕见的基因组成

Epidermal growth factor receptor and its ligands (EGF and TGFα) are over-expressed in a variety of tumors. Immunization EGF-carrier protein inhibits tumor growth through abrogating binding of EGF to EGFR.

表皮生长因子受体(Epidermal growth factor receptor ， EGFR)及其配体在多种肿瘤细胞中高表达，免疫注射表皮生长因子(Epidermal growth factor，EGF)-载体蛋白所产生的抗体能够干扰EGFR与EGF的相互作用，进而抑制肿瘤生长。

NK ceils are crucial components of the innate immune system, which express multiple activating and inhibitory cell-surface receptors.

NK细胞是肌体免疫系统至关重要的组成部分，其表达多种活化性和抑制性细胞表面受体。

Rates of the expression of HSP90a in the deciduas of habitual...

在习惯性流产患者中，HSP通过持续诱导炎症反应和免疫反应、引起体内激素紊乱、子宫敏感性增强等多种原因而导致流产

The inward currents evoked by ATP was decreased in hypoxia condition,but suramin can still inhibit the depolarizing currents.

免疫组化实验结果显示在大鼠海马CA1区有多种P2X受体亚型的表达，低压缺氧可以引起P2X受体各个亚型表达的上调。

The researchers conclude that the absence of functional Tyk2 caused the defects in the multiple cytokine signals that were observed in the patient and identify human Tyk2 mutation as a unique type of primary immunodeficiency with characteristics similar to autosomal recessive HIES.

研究人员总结到，Tyk2功能缺失会导致多种细胞因子信号通路发生缺陷，就像在人类HIES患者中观察到的一样；人类Tyk2突变作为原发性免疫缺陷的一种类型，特征与常染色体隐性HIES相似。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。