多种免疫

Trimolecular complex will be activated T cells, immune cells leading to a variety of abnormalities, a variety of cytokines and antibody, and then, like a domino effect caused a series of the same immune response, resulting in blood vessels and synovial inflammation .

三分子复合物会激活T细胞，导致多种免疫细胞的异常，产生各种不同的细胞因子和抗体，然后会像多米诺骨牌效应一样引起一系列的免疫反应，从而导致血管和关节滑膜的炎症。

The endogenous level of IFN-γis an important index of body's cellular immune status. The quantitative determination of IFN-γconcentrations has very significant theorical and practical values in immune mechanism research,immune function assay,the efficacity evaluation of vaccine,transplant operation,hypersensitive reaction and intracellular pathogen diagnosis.

研究表明，内源性IFN-γ水平的高低在很大程度上可以反映机体的细胞免疫状态，因此对样本中的IFN-γ进行定量分析，在免疫机制研究、免疫功能分析、疫苗免疫效果评估、器官移植、过敏反应以及多种胞内病原感染的诊断等方面都具有极其重要的理论价值和应用价值。

During the course of phagocytosis, the host glycolytic reactions get activated which in turns increase the consumption of oxygen and induce the production of a mass of reactive oxygen species.

另外，受到病原侵染的对虾还会产生其他多种免疫反应，这些免疫反应将消耗大量的能量，产能的呼吸链会加速运转，由此也会引发大量活性氧的产生。

Therefore, a great many of immunocytes and cytokines are involved in the development of psoriasis.

因此，银屑病是由多种免疫细胞和细胞因子共同参与的疾病。

Adenosine has been shown to inhibit T cell specific tyrosine and serine/threonine protein kinases.

近年来研究发现，腺苷对多种免疫效应细胞都有抑制作用，是一种具有免疫抑制的活性的分子。

Reporter molecules (thiophenol, bipyridine derivates, cyanopyridine derivates) were attached to different immuno-gold colloids, respectively. By means of the specific adsorption between antigen and antibody, a sandwich structure was constructed, in which labelled immuno-gold colloids and antigen covalently bound to substrate specifically capture different antibodies.

以多种不同的标记分子(苯硫酚，联吡啶类分子，氰基吡啶类分子)分别标记多种不同免疫金溶胶，通过抗体抗原之间所具有的特异吸附性，进一步组装"固相抗体-待测抗原-标记免疫金溶胶"多组分三明治复合体系。

By the regulation of idiotype networks, they can control immune system in body.

第三章研究多种免疫细胞作用下的免疫系统的模型。

Thymosin 1（Tα1） is a acidic protein composed of 28 amino acid residues with isoelectric point 4.2 and molecular weight 3102.Its amino acid sequence is: N-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu -Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-C. T1 is a T-cell potentiating factor.

胸腺素α1（thymosin 1，Tα1）是由28个氨基酸组成的酸性多肽，等电点4.2，相对分子量3108，其氨基酸序列为：N-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-C[1，2]。Tα1具有多种免疫活性，可以促进T淋巴细胞的成熟和分化，促进成熟的T细胞、自然杀伤细胞分泌各种细胞因子如IL-2、INF-α等，同时也促使高亲和力白介素-2受体的生成[3-10]。

Swine enteropathogenic E. colis were rejuvenescenced and 6 of them were selected to prepare blood serum. We had tested the reactance of cross agglutination and agar diffusion between the strains and the blood serums. No. 300 and No. 343 were selected because they had highly cross reaction. To test superantigen of No.300 and No.343, the antigens made by both of them immunized piglets, and then we detected the serum 0D values with indirect ELISA. The OMP and PF of No. 300 and No. 343 were extracted for SDS—PAGE and westen-blotting.

本研究针对10株猪致病性大肠杆菌，经复壮后选取致病性强的6菌株作为供试菌株，制备免疫血清与这6菌株的多种抗原分别进行交叉凝集试验和琼脂扩散试验，根据各菌株抗原的交叉反应程度，筛选出抗原交叉程度高的菌株300和343，检测两菌株超抗原的毒性作用，以不同方式制备抗原免疫仔猪，用间接ELISA检测免疫效果，并提取菌株300和343的外膜蛋白和渗透因子经SDS—PAGE及免疫印迹试验，进行相关分析。

objective to establish immunological methods specific for detecting antigens in different groups of monoclonal antibodies.methods indirect immnofluorescence assay was applied to identify specificity of the two groups of monoclonal antibodies prepared with crude antigen and recombinant antigen of aspergillus fumigatus,respectively.two different double monoclonal antibody sandwich elisa assays established with the two groups of antibodies were performed to detect antigents in the cell culture supermatants of 19 common species of aspergillus,penicillium marneffei,and 5 species of candidas.results the results of indirect immnofluorescence assay indicated that the monoclonal antibodies prepared with crude antigen of aspergillus fumigatus were specific for antigens in both clinical isolates and environmental isolates of aspergillus, whereas the other group of monoclonal antibodies was proved to be specific for aspergillus fumigatus of both clinical and environmental isolates.the elisa assay established with the crude antigen-specfic monoclonal antibodies could detect both of the clinical and environmental isolates of aspergllius, while the other assay could only detect aspergillus fumigatus of both clinical and environmental isolates.and no cross reaction with the cell culture of penialllium marneffei and candidas was observed with the two methods.conclusion the elisa assays can detect both of the clinical and environmental isolates of aspergillus,and differentiate aspergillus fumigatus from other species of aspergillus.

目的 用2组曲霉单克隆抗体建立特异性识别不同种类曲霉抗原的检测方法。方法采用天然烟曲霉抗原免疫，获得广谱针对曲霉抗原的单克隆抗体；采用重组烟曲霉抗原获得特异性针对烟曲霉抗原的单克隆抗体，用间接免疫荧光鉴定，并分别建立2种双抗体夹心elisa法，对19种常见的环境和临床分离曲霉株、马尔尼菲氏青霉菌及念珠菌培养液进行检测。结果间接免疫荧光显示，用天然烟曲霉抗原免疫获得的单克隆抗体(mabs-1)可广谱识别多种曲霉分离株，而重组烟曲霉抗原获得的单克降抗体(mabs-2)仅能特异性结合临床和环境分离的烟曲霉抗原。用mabs-1建立的双抗体夹心elisa法可检测19种常见曲霉株培养液；用特异性针对烟曲霉抗原单克降抗体(mabs-2)建立的双抗体夹心elisa法可特异性检测临床和环境分离株烟曲霉培养液；与其他曲霉株无交叉反应；2种双抗体夹心elisa法与马尔尼菲氏青霉菌及念珠菌培养液均无交叉反应。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。