多病

Worldwide, over 4,000 patients with Gaucher disease have received ERT, which is safe and well tolerated.

在全世界，4000多戈谢病患者接受了酶替代疗法，这种疗法安全且有良好的耐受性。

This disease much because of the germ spot, tartar, the food Qian fills and badly repairs a body and bites wound etc. to cause, the gum inflammation swells and makes the germ spot piled up to aggravate in the meantime, and is expanded to postpone to the gums bottom by the gums.

本病多因为菌斑，牙石，食物嵌塞，不良修复体，咬创伤等引起，牙龈发炎肿胀，同时使菌斑堆积加重，并由龈上向龈下扩延。

Objective: To study the relationship between the exon 1 A/G polymorphism of the CTLA-4 gene and the response to antithyroid drugs in Graves' disease.

目的：对Graves病患者CTLA-4基因外显子1第17密码子49位点A/G多态性与GD患者的临床特点及其对抗甲状腺药物的疗效关系进行研究，为临床治疗的决策提供依据。

The first aim of this study is to clarify whether that polymorphisms of the genes that encode these enzymes associates with the TB drugs-induced adverse reactions. Furthermore, since tuberculosis patients are always administrated with multiple TB drugs, it is hard to distinguish which TB drug caused these adverse reactions.

本研究从结核药物过敏病患代谢酵素基因多型性方面探讨与结核药物过敏反应发生的相关性；此外，由於结核病患通常同时接受多种结核药物的治疗，导致难以判断是其中何种药物引起不良反应，本研究另一目标即为建立一T细胞体外培养系统，用於判断何种药物引起不良反应的产生。

A disease called Hemochromatosis is caused by too much iron in the blood.

称为血色病的疾病是由于太多铁在血液中。

Results Among 54 WD patients, 36 were found to carry Arg778leu mutation, among whom 15 were homozygote, 21 were heterozygote, the frequency of this mutation was 47.2%. Of 46 patients with hepatic damage, 36 were found to have the mutation of Arg778Leu, among whom 34 were found to have Leu770Leu polymorphism simultaneously.

结果 54例Wilson病患者中36例存在Arg778Leu基因突变，15例为纯合型，21例为杂合型，Arg778Leu等位基因突变频率为47.2 ％；46例伴肝损害的患者中33例存在ATP7B基因外显子8的Arg778Leu突变；36例Arg778Leu突变者中34例同时伴有Leu770Leu多态性。

To meet military, economic and cultural needs, more and more people are entering into high-altitude regions.

随着军事、经济、文化的发展，越来越多的人进入高原，对高原病发病机制、临床症状、预防及治疗等研究成为热点。

Research background: Choroidal neovascularization is a common cause of vision loss in patients, which often resulted from exudative Age-related macular degeneration、 pathologic myopia、 central serous chorioretinopathy、ocular histoplasmosis and angioid streaks, Rarely, CNV is seen in children, usually in association with inherited macular dystrophies. Despite extensive basic and clinical research, our knowledge of the complicated molecular mechanism of CNV is still limited, for these reasons currently used therapeutic approaches are insufficiently effective.

课题研究背景：脉络膜新生血管(choroidal neovascularization，CNV)是导致视力丧失的一种常见原因，多继发于渗出型年龄相关性黄斑变性、近视性黄斑变性、中心性浆液性脉络膜视网膜炎、眼组织胞浆菌病和眼底血管样条纹等眼病，在儿童罕见，主要与遗传性黄斑营养不良有关，尽管近年来进行了大量的基础和临床研究，但对CNV复杂分子机制的认识仍然非常有限，因此目前的治疗措施都不尽如人意。

One patient taking infliximab developed tuberculosis and one developed histoplasmosis. Five patients (four taking infliximab and one taking placebo) developed cancer. New autoimmune disorders developed in two patients taking infliximab and one patient taking placebo. Two patients developed optic neuritis and one developed a multifocal motor neuropathy; all three were taking the study drug.

英夫利昔单抗组1例患者发生结核病，1例发生组织胞浆菌病。5例患者(英夫利昔单抗组4例，安慰剂组1例)发生癌症。2例英夫利昔单抗组患者和1例安慰剂组患者新发自身免疫性疾病。2例患者发生视神经炎，1例发生多灶性运动神经病；这3例患者均服用了英夫利昔单抗。

ALCL was not uncommon in children. The differential diagnoses included malgnant histiocytosis, T zone or pleomorphic T-cell lymphoma, Hodgkins lymphoma, mycosis fungoides, and metastatic carcinoma.

小儿间变性大细胞性淋巴瘤并不少见，需与恶性组织细胞增生症、T区或多形T淋巴瘤、霍奇金淋巴瘤、蕈样霉菌病和转移性癌等鉴别。

Lugalbanda was a god and shepherd king of Uruk where he was worshipped for over a thousand years.

Lugalbanda 是神和被崇拜了一千年多 Uruk古埃及喜克索王朝国王。

I am coming just now,' and went on perfuming himself with Hunut, then he came and sat.

我来只是现在，'歼灭战perfuming自己与胡努特，那麼，他来到和SAT 。