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Results (1) 6 cases of Tuberous Sclerosis. Diffused subependymal nodular calcification lesions were found in all cases on unenhenced CT. 4 patients are 2 pairs of mother/child relationship. Both of the two mothers are found to suffer from renal angiomyolipoma.(2)1 case of neurofibromatosis showed abnormal spinal canal: scoliosis of thoracic and lumbar spine, concave change of vertebral posterior border. Bilateral renal hypogenesis was found in this patient. Diffused hyper-density lesions were found in kidney and fatty accumulation was found in back skin.(3)6 cases of Sturge-Weber syndrome. On unenhenced CT, curving and strip-shaped calcifications were found along the parietal and occipital gyrus.

结果 ①结节性硬化6例,所有病例CT平扫见两侧脑室室管膜下多发小结节状高密度钙化灶,其中4例为两对母子关系,并见两位母亲合并有肾脏错构瘤,;②神经纤维瘤病1例,MRI表现为椎管异常,胸腰段脊柱侧弯,椎体后缘呈明显的切凹改变;伴有双肾发育不良,CT示肾内多个高密度影,背部皮肤多量脂肪堆积,③脑颜面血管瘤综合征6例, CT可见顶枕部沿脑回分布的弯曲的条状高密度钙化,部分延伸致侧脑室内,增强后见病灶内有扭曲的条状和结节状明显强化的血管影;④小脑血管瘤病4例,影像学表现为小脑内大囊、小结节样占位性病变。

Results Interlobular septa thickening was shown in 16 cases; ground-glass opacification was revealed in 14 cases; irregular lines were found in 11 cases, bronchiolcctasis was noted in 7 cases; micro nodules were demonstrated in 4 cases; and honey combing alteration was visualized in 3 cases.

结果 28例肺类风湿性病活动期患者CT异常改变显示:①小叶间隔增厚16例,②不规则纤维索条影11例,③磨玻璃样变14例,④牵拉性细支气管扩张7例,⑤结节状气腔实变病灶4例,⑥蜂窝样灶3例,以网格样及磨玻璃样病变多见。2种表现的CT评分结果与肺弥散功能存在负相关性。

Under optical microscope, the cell of NS arrayed as nest, the nuclear was big, deep-stained, thickened-karyotheca, chromatin granulated, Pathologic karyokinesis can be seen.

DDP组癌巢周围可见少量纤维组织增生、局灶性坏死,并可见炎细胞浸润;LNT组镜下见少量细胞凋亡,凋亡细胞变小,变圆,核固缩,胞浆浓缩,染色加深,凋亡细胞周围未见炎症反应;LNT+DDP组与LNT组镜下大体相同,但可见到较多量的凋亡细胞。

Each group with drug had effect on inhibiting Lewis lung cancer tumor,LNT DDP had the best effect,46.2%,the rate of inhibitory effect of LNT、DDP was 35.6%、39.7%respectively.3.Under optical microscope,the cell of NS arrayed as nest,the nuclear was big,deep-stained,thickened-karyotheca,chromatin granulated,Pathologic karyokinesis can be seen.

DDP组癌巢周围可见少量纤维组织增生、局灶性坏死,并可见炎细胞浸润;LNT组镜下见少量细胞凋亡,凋亡细胞变小,变圆,核固缩,胞浆浓缩,染色加深,凋亡细胞周围未见炎症反应;LNT DDP组与LNT组镜下大体相同,但可见到较多量的凋亡细胞。

Results ①The most common lesions were the extragastric compressions caused by spleen, which accounted for 54.74%, followed by the enlarged gallblodder, hepatic cyst and carcinoma in the left lobe, left kidney, pancreatic cystic adenoma and pancreatic cyst.②The diagnostic accurancy of EUS was 100%, which was higher than that of USP.③Most of the lesions, benign or malignant, had normal structure of the gastric wall.④Splenomegaly only accounted for 38.46% in the lesions caused by the compression of spleen, which were slightly to moderately enlarged.⑤The location of the lesion was usually related to the organ which caused the extragastric compression.

结果 ①胃外压性隆起中脾脏压迫最多见,占54.74%,其余为肿大胆囊、肝右叶囊肿、肝左叶癌、左肾、胰腺囊腺瘤和胰腺囊肿;②EUS对胃外压性隆起的诊断正确率达100%,其对外压灶的完全显示率高于微超声探头;③良性胃外压灶及多数恶性肿瘤胃外压灶其所压胃壁结构均正常;④脾脏压胃者中脾肿大仅占38.46%,且均为轻、中度脾肿大;⑤胃隆起部位与外压灶的种类相关联。

The clinical features of PCAA included: forming giant aneurysm in about 80% cases; presenting SAH and induciag focal symptoms e. g. hemiparalysis, paralysis of oculomotor or hemianopsia; showing massive lesion around cerebral peduncule or internal temporal lobe on CT scan; being associated with a fetal PCA.

PCAA的临床特点是:(1)易形成巨大动脉瘤,约占80%;(2)临床表现以SAH最多见,且也常有局灶性症状,如偏瘫,动眼神经麻痹、同向偏盲等;(3)CT检查常可见大脑脚旁或颞叶内侧占位病变;(4)常伴有胎儿型PCA。

Moutains of evidences from laboratary and clinical data show that gene abnormality is the major etiological factor of over 40% patients affected with epilepsy.There were also 6 epilepsy genes been cloned successfully, and mutations of over 1000 genes maybe related to epilepsy. These abnormal genes influence many aspects from molecular level to the neuronal plasticity, such as the development of brain,neuronic degeneration, remodeling of neural circuits, energy metabolism, ion channel and so on.These factors would at last affect the formation of epilepsy focus, propagations of epileptic potentials, vulnerability of epilepsy cells.

大量的实验和临床资料提示基因异常是40%以上癫痫患者的病因,有6种常见全身癫痫的基因已被成功克隆,1000种以上的基因突变可能与癫痫的发作有关,这些表达异常的基因分布在脑发育、神经元变性及神经环路重组、能量代谢、离子通道等多个环节,从分子、细胞、神经元可塑性等多个方面影响着癫痫灶的形成、痫性放电的扩布及癫痫细胞的损伤,构成了癫痫的基因机制。

Objective To evaluate the effect of a new localization mode and the effects of lesionectomy and/or multiple subpial transectionunder monitoring of intra-operative ECoG recordings for treatment of intractable epilepsy.

目的评价难治性癫痫的致痫灶定位方法和皮层电极监测下致痫灶切除,加行多处软脑膜下横纤维切断术治疗癫痫的疗效。

Results 99Tcm-ECD SPECT: 19 of the 20 patients showed brain cortex single focus or multiple foci which were either local or diffuse. The perfusions in the abnormal areas were decreased prominently.

结果 99Tcm-ECD SPECT 示:20例脑积水患儿中19例显像异常,异常率为95%,其中显示脑室扩大者8例(40%)。19例脑灰质异常者分别表现为单个或多个,单侧或双侧、对称性或非对称性、局灶性或弥漫性的放射性减低区,异常减低区的范围大小、数目、程度与临床病情相关。

Results Group C had the symptoms such as reduced activity, acceded, indulge in lying and weight loss after 3 weeks of immune injection, 14 out of 16 SD rats in Group B had the same symptoms as Group C after 4~5 weeks of immune injection, the serum enzymes in model groups increased significantly compared with those of the control group, model group C was much higher than model group B; the duration shorted, amplitude decreased, multiphase wave increased in electromyogram of model groups; MRI examination revealed samples from model group B and C had one positive case each, which presented T1MI isodensity or hypodensity signal, T2MI and STIR serial hyperdensity signal, revealing muscle inflammation; all rats'skeletal muscle from model group C and 11 out of model group B had pathological changes, which exhibited striated muscle focal fiber degeneration, necrotized and inflammatory cell infiltration, interstitial vessel wall thickening, random cardiac muscle samples had 3 positive changes, which had similar changes to skeletal muscle, there was 1 positive change from lung sample.

结果:模型C组于免疫注射第3周左右开始出现活动减少,倦怠嗜卧,食欲体重下降等表现,模型B组有14只SD大鼠于免疫注射第4~5周出现上述症状,较C组为轻;模型组肌酶谱中,肌酸激酶、乳酸脱氢酶、谷草转氨酶与对照组比较明显升高,模型C组较模型B组升高更显著;模型组肌电图时限缩短,波幅降低,多相波增多;磁共振检查模型B组和C组选送标本中各有一例有阳性改变,表现为T1MI等或稍低信号,T2MI及STIR序列为高信号,提示肌肉炎症水肿改变;模型B组有11只,模型C组全部大鼠骨骼肌出现病理改变,表现为横纹肌局灶性分布的肌纤维变性炎细胞浸润,间质小血管壁增厚、扩张,随机选送的心肌标本中有3例有阳性改变,表现与骨骼肌相仿,选送的肺标本中有1例有阳性改变,表现为蛋白渗出,炎症细胞浸润和小血管改变。

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