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多核细胞

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It is characterized by ineffective erythropoiesis and by the presence of bi- and multinucleated erythroblasts in bone marrow, with nuclei of equal size and DNA content, suggesting a cytokinesis disturbance.

它的特征是无效红细胞生成以及骨髓中存在的双核和多核幼红细胞,这些细胞含有等量的细胞核和DNA成分,提示胞浆紊乱。

Pleomorphic giant nucleus(100%), obvious nucleoli(75%) and karyokinesis were the main elements in the smear of bone metastatic carcinoma.

骨转移性癌则以无多形性大核细胞(100%)、核仁明显(75%)、有核分裂象为主要特征。

Results:The tumor was divided into two histologic subtypes:biphasic type(4 cases) and monophasic type(1 case).

结果 :组织学检查分为双相性SRCC 4例,由癌和肉瘤样成分组成;单相性 1例,由差分化的肉瘤样梭形细胞、单核细胞与破骨细胞样多核巨细胞组成。

Methods Marrow cells from NH mouse were harvested and cultured in α-MEM with 10% fetal bovine serum.The appearance of tartrate-resistant acid phosphatase-staining multinuclear cells and formation of bone resorption pits were measured after 3,6,9 and 12 day exposure to various concentrations of 1,25-2D3 in culture. Results 1,25-2D3 (concentration higher than 10-9mol/L) could induce recruitment of OLCs and their bone resorption activity in a dose-dependent manner.

收集NH小鼠骨髓细胞于含10%胎牛血清的α-MEM培养基中行体外培养,设置不同的1,25-2D3浓度组和给药时间组,并于培养第3、6、9、12天观察记录抗酒石酸酸性磷酸酶(tartrate-resistant acid phosphatase,TRAP)阳性多核巨细胞[或破骨细胞样细胞(osteroblast-like cell,OLC)]以及骨磨片上骨吸收陷窝的数目。

Gradually, bulky cells with filamentous structures predominated the cell population and multinucleated giant cells accumulated.

逐渐地,细胞群中多呈含有丝状细胞质构造的肿胀细胞且可见到多核巨细胞的出现。

Myoblast differentiation and fusion in multinucleated muscle cells was studied in myoblasts growth in culture. The content ofcalpastatin in muscle wonld be related to cell membrane fusion.

在成肌细胞培养中,成肌细胞融合并分化形成多核肌细胞,其中钙激活酶抑制蛋白的含量与细胞膜的融合相关。

293T cells transfected with ACE2, but not those transfected with human immunodeficiency virus-1 receptors, formed multinucleated syncytia with cells expressing S protein.

转染了ACE2的293T细胞能与表达S蛋白的细胞形成多核体,而同样的293T细胞转染了人免疫缺陷病毒-1则不行。

The results showed that the cells had classic characteristics of osteoclasts: multinucleated giant cells, staining positively for TRAP in cells, forming bone absorptive lacunae on the bone slices.

结果表明,直接分离的细胞具有典型的破骨细胞的形态特点:属多核大细胞,TRAP染色阳性,能在骨片表面形成吸收陷窝。

RESULTS In contrast with the control, more cells of the experimental group entered S phase during the early differentiation (24 h, 48 h), whereas a smaller number of cells entered during the late differentiation (72 h) when multinucleated myotubes began to form.

结果 发现肌细胞分化早期即24, 48 h时,与对照组比有更多的细胞进入S期;分化后期即72 h多核肌管形成时,S期比对照组明显减少,而G0/G1期明显高出对照。

After culture on coverslips and bovine cortical bone slices for 1, 3, 5, and 7 days, morphologic features, TRAP staining and bone absorptive lacunae were observed to evaluate osteoclast cells.

结果显示,当培养细胞在RANKL和M-CSF联合作用下,TRAP阳性染色的单核和多核破骨细胞可在3天内迅速形成,骨片吸收实验显示骨片上出现典型的骨吸收征象;在M-CSF(50ng/ml)协同作用下,RANKL呈剂量依赖型诱导TRAP阳性破骨细胞生成。

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