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Objective: To investigate the relations of the insertion/deletion polymorphism of angiotensin I converting enzyme gene in mid-aged population of different races.

目的:探讨血管紧张素转换酶(angiotensinIconvertingenzymeACE)基因内含子16中的插入/缺失多态性在不同种族中老年人群之间的相互关系。

This study investigated gene polymorphism of β_1-AR, CY2PD6, ACE and of BDKRB2 in the population of Hunan mid-region by PCR and PCR-RFLP method. The results showed that the frequencies of Ser49Ser and Arg389Arg genotype of β_1-AR gene were respectively 68.7% and 55.3%. And the allele frequencies of 49Ser and 49Gly were 83.9% and 16.1%, moreover 76.1% for 389Arg and 23.9% for 389Gly.

本研究应用PCR、PCR-RFLP方法首次对湖南中部地区403例原发性高血压患者的β_1-AR基因、CY2PD6基因、ACE和BDKRB2基因多态性的调查,结果显示:β_1-AR基因型Ser49Ser、Arg389Arg分别占68.7%、55.3%,49Ser和49Gly等位基因频率分别为83.9%、16.1%,389Arg和389Gly等位基因频率分别为76.1%、23.9%;CYP2D6等位基因频率由高到低依次为~*10、~*1、~*2、~*5,CYP2D6~*10~*10基因型频率最高,占47.4%;ACEI和D等位基因频率分别为55.8%、44.2%,基因型频率分别为Ⅱ型33.5%、ID型44.7%、DD型21.8%;BDKRB2-58T/C等位基因频率C、T分别为52.6%、47.4%,基因型频率分别为CC型24.8%、CT型55.6%、TT型19.6%。

The advantages and disad vantages of these three molecular marker systems were discussed.

对上述三种分子标记各自的优缺点及它们在DNA多态性检测中的适用之处进行了分析探讨。

Polymorphism of HLA-DQB1 promoter region in Hans IDDM patients and normal controls have been identified by PCR, PCR/SSCP and PCR/sequencing methods.No differences were found in y and s box between patients and controls carrying different allele as well as in different ethnic groups. There are two different sequences in x box,but CCTAGAGACAGATT sequence locates frequently on the haplotype with DQB1.0302 allele. Polymorphism between transcription point and y box (at position -44~-46 and -59~-61) might be associated with the genetic susceptibility to IDDM. Additionally,a new single base mutant (CACC→CAC A ) was found at position -131 and -128 in two patients carrying DQB1.0601 allele.

结果显示携带不同等位基因的患者与对照者DQB1 5'-调控区y、s box核苷酸序列相同,且与白种人基因结构一致;y box核苷酸序列存在二种结构,CCTAGAGACAGATT序列常常与DQB1.0302等位基因在同一单倍型;转录起始位点至y box间-44至-61位存在多态性,-59至-61位AAG等位基因可能与1-型糖尿病易感相关联;在2例携带DQB1.0601等位基因患者的-131至-128位间发现CACC→ACA A单个碱基取代突变。

Can detect and remove rootkits, mass-mailing worms, e-mail viruses, peer-to-peer viruses, Internet worms, file viruses, Trojans, stealth viruses, polymorphic viruses, bodiless viruses, macro viruses, MS Office viruses, script viruses, spyware, spybots, password stealers, keyloggers, paid dialers, adware, riskware, hacktools, backdoors, joke programs, malicious scripts and most other malware.

可以检测和删除的rootkit ,邮件群发蠕虫,电子邮件病毒,点对点病毒,互联网蠕虫病毒,文件病毒,木马,隐形病毒,多态病毒,脱胎病毒,宏病毒,病毒的MS Office ,脚本病毒,间谍软件, spybots ,密码盗取者,键盘记录程序,支付拨号,广告软件, riskware , hacktools ,后门,玩笑程序,恶意脚本和其他大多数恶意软件。

In this paper,from the inheritance and polymorphism two side,discuss how to compare the DCS with the O-O technology .At the same time,auther put forward some ideas by oneself.

在本文中,从继承性与多态性两方面讨论了将这两项最新技术相结合的方法及受益之处,并提出了自己的一些看法。

The results show that there is obvious polymorphism in rice prolamine content among the lines studied.

发现水稻醇溶蛋白的总含量存在着较大的多态性。

Finally, all mutations of FV gene in probands and their family numbers were confirmed by .restriction enzyme analysis. Their occurence were investigated in the control group.

用限制性内切酶证实变的FV基因在患者家系成员中的分布情况,并在正常对照人群中进行了多态性分析。

The polymorphisms of DNA were determined in four pairs of primers from 145 pair of SSR primers.

通过145 对SSR引物的筛选和鉴定,检测出4对引物的多态性。

Furthermore, the properties of polarons in polar crystals are investigated by taking account of the influence of pressure effect and the electrons emitting or absorbing many virtual phonons.

考虑电子发射和吸收多个虚声子的影响,讨论了压力作用下极性晶体中极化子基态的性质。

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