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Objective To study the correlation between the angiotensin converting enzyme gene polymorphism and cerebral hemorrhage.

目的 探讨血管紧张素转换酶基因多态性和脑出血发病的关系。

Objective To explore the relationship between angiotensin Ⅱ type 1 receptor (AT1R) gene polymorphisms and cerebrovascular disease.

目的 探讨血管紧张素Ⅱ受体-1(AT1R)基因多态性与脑血管病的关系。

Objective To investigate the genetic association between APOD gene and schizophrenia in the North Chinese Han population.

目的:探讨中国北方汉族人群载脂蛋白D基因多态性与精神分裂症的关系。

Objective To detect the relationship between ApoE gene polymorphism and coronary heart disease, arteriosclerotic cerebral infarction.

目的 探讨ApoE基因多态性与冠心病、脑梗塞的相关关系。

Objective To study the genetic association of CC16 gene polymorphism with atopy.

目的 研究CC16基因多态性与特应症遗传易感性之间的关系。

ObjectiveTo study the genetic association of CC16 gene polymorphism with atopy.

目的研究 CC16基因多态性与特应症遗传易感性之间的关系。

This study,by use of RAPD and esterase isoenzyme technique,examined the genetic structure and divergence among the natural population of the coccoidea(Eulecanium kuwanai Kanda;Eulecanium gigantean Shinji;Parthenolecanium corni Bouche) collected from different areas in Hebei.

本文采用随机扩增多态性DNA技术和酯酶同工酶标记检测了蚧虫在河北省不同地区种群之间皱大球蚧Eulecanium kuwanai Kanda、瘤坚大球蚧Eulecaniumgigantean Shinji、扁平球坚蚧Parthenolecanium corni Bouche 10个种群的遗传多样性及遗传分化。

Polymorphism investigation on 15 STR loci of mongolia population from buriat.

中国布里亚特蒙古族人群15个STR基因座的遗传多态性。

Recently Camacho et al, proposed the polymorphisms of Bs is changing and developing.

最近Camacho等提出其多态是变化发展的。

①Location of WD gene in Ch inese: Using pairwise linkage analysis and multipoint linkage analysis method, w e constructed a genetic map of DNA markers within D13q14.2-3 which refined the location of WD gene by restriction fragment length polymorphism and microsatellite polymorphism analysis;②Screen for mutations of WD gene in Chinese people: we detected the structure of 21 exons of WD ge ne in 45 patients from 39 pedigrees by PCR-SSCP(Single strand conformation poly morphism) and PCR-DNA sequencing technology, found a new mutation in exon 5 and nuclcotide sequence analysis showed it is a T insertion. We also conformed the Arg778Leu in exon 8, the highest frequence mutation point in Chinese people, wit h mutation rate 22.8%in total;③Carrier detection and presymptomatic diagnosi s of WD: Based on DNA recombination technology, we peformed successfully the gen e diagnosis in all individuals of 79 families with WD and built up a helpful spe cific enzyme cut method (PCR-Msp1) to detect the carrier and presympomatic patients in Chinese pe ople with WD.

①WD的基因定位研究:通过RFLP及微卫星多态性分析,应用两位点及多位点连锁软件,建立了中国人WD基因在D13q14.2-3区域的精细遗传连锁图谱,从而首次对中国人WD基因进行了精确定位;②WD基因突变研究:应用PCR-SSCP及DNA测序技术,对39个家系45名WD患者进行该致病基因的21个外显子突变筛选,发现WD基因5号外显子存在新的T插入突变,并证实中国人WD基因的突变热点为8号外显子,突变形式为Arg778Leu,其频率为22.8%;③WD的症状前诊断和杂合子检出:应用DNA重组技术对79个家系进行基因诊断,成功地进行了WD的症状前诊断和杂合子检出,并建立了WD的基因筛选的PCR-Msp 1酶切方法。

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