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Objective: This paper aims to verify the curative effect that Jiusuyu cure the acute alcoholism disease by counting the changes of ebriety time, ebriety rate, sober-up time death rate, and discuss the effect of neurotransmitter and oxidative damage on acute alcoholism mice in brain tissue by examining the changes of SOD, MDA, DA, 5-HT, AchE in btain tissue.

目的:本研究旨在通过观察急性酒精中毒小鼠模型醉酒时间、醒酒时间、醉酒率、死亡率来验证酒速愈的药效,并通过检测脑组织中超氧化物歧化酶、丙二醛,纹状体多巴胺、5-羟色胺(5-HT)和海马胆碱脂酶指标的变化探讨该药对急性酒精中毒小鼠脑神经递质和氧化损伤的影响。

It is shown from the analytical results that in the depressed rats' brain, the contents of homovanillic acid, noradrenaline, dihydroxyphenyl ethylamine and 5-HT increase in the presence of the saikosaponin A. These results can help to clarify the mechanism of saikosaponin A in curing the depression.

实验结果表明,柴胡皂苷A可使抑郁型大鼠脑中的高香草酸、去甲肾上腺素、多巴胺及5-羟色胺的含量升高,这一结果有利于对柴胡皂苷治疗抑郁症的物质基础及相关机理进行更深入了解。

Object To investigate the effects of chronic nicotine treatment on the functions and gene expressions of monoamine receptor.

目的 研究烟碱对多巴胺受体、肾上腺素受体、5 羟色胺受体功能及基因表达的影响。

These effects were accompanied by loss of nigral dopaminergic cells but not of raphe cell bodies or 5 HT immunoreactivity.

这些作用伴随黑质多巴胺能神经元的丢失,但中缝核的细胞数量和形态以及5-羟色胺(5-HT)免疫组织化学反应与对照组相同。

Methods The model of nitroglycerin migraine was made after rat treated by gastrodin for 5 days, the time points of ear rubescence and the times of scratch head were observed to take as evaluation index of pharmacodynamic action, the concentration of 5-HT, NE and DA were measured in the brain with HPLC.

天麻素预防给药5 d,于第5天给药后皮下注射硝酸甘油复制偏头痛模型,并观察其耳红、挠头次数等行为学指标,采用高效液相色谱法测定各组大鼠脑组织中5-羟色胺、去甲肾上腺素和多巴胺的含量变化。

Now scientists realize that schizophrenia is a complex syndrome resulting from the failure of various neurotransmitters--the chemical messengers that skip from one nerve cell to the next--including dopamine, serration and 5-hydroxytryptamine.

现在科学家认为,精神分裂症是由于各种神经递质功能障碍导致的一种复杂综合症。神经递质是化学信使,它能从一个神经细胞传递到另一个神经细胞,包括多巴胺、血清素和5—羟色胺。

Results: Akebia fruit alcohol extract can reduced the immobility time in both of the tail suspension test and the forced swim test of mice. Akebia fruit alcohol extract significantly increased the rate of death of injecting dopamine and enhanced the apomorphine-induced stereotypy, could increase the head-twitch response evoked by 5-HTP, but it had no direct activation on reuptake of noradrenalin.

结果:预知子乙醇提取物能够显著缩短小鼠悬尾及强迫游泳不动时间;显著增加多巴胺致小鼠死亡作用和阿朴吗啡致小鼠刻板运动作用;增加5-羟色胺酸(5-HTP)致甩头作用,但对去甲肾上腺素重摄取抑制作用不明显。

Hours later,these mice were decapitated,and the striatums were isolated from thebrains. The levels of dopamine, serotonin ( 5-HT ), homovanillic acid, 5-hydroxyindoleacetic acid ( 5-HIAA ) andnorepinephrinein the striatum were measured by high-performance liquid chromatography with electrochemical detection.

给3组小鼠分别喂食Dieldrin 50 mg·kg-1体重、Dieldrin 40 mg·kg-1体重和等量的生理盐水,3 h后处死小鼠,取纹状体匀浆用高效液相色谱-电化学检测法测定纹状体中多巴胺、5-羟色胺(5-HT)、高香草酸、5-羟基吲哚乙酸(5-HIAA)和去甲肾上腺素的含量。

Xingpikaiyu Formula ; depression model ; neurotransmitter ; 5_hydroxytryptamine ; homovanillic acid ; dopamine

醒脾开郁方;抑郁模型;神经递质; 5-羟色胺;高香草酸;多巴胺

Objective: To explore the content changes of plasmic neuropeptide Y, norepinephrine, 5-hydroxytryptamine (5-HT), dopamine and their clinical significance in patients with coronary heart disease accompanied by anxiety.

目的:探讨冠心病合并焦虑障碍患者血浆神经肽Y、去甲肾上腺素、多巴胺、5-羟色胺(5-HT)水平的变化及其临床意义。

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