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Mesencephalic neural stem cells of rats at different gestational days have different capabilities to differentiate towards dopaminergic neurons.

不同胎龄大鼠中脑的神经干细胞体外诱导向多巴胺能神经元分化的能力不同,以孕12 d诱导分化成多巴胺能神经元比例最高。

This study investigated the effect of transplantation of dopaminergic neurons differentiated from neural stem cells into Parkinson's disease rats, and compared to the transplantation of embryonic mesencephalic DNs.

观察神经干细胞诱导分化的多巴胺能神经元移植治疗帕金森病大鼠的作用,并与胚胎中脑多巴胺能神经元组织移植治疗帕金森病大鼠的疗效进行比较。

Rat ventral mesencephalic precursors can be induced to differentiate into plenty of tyrosine hydroxylase-positive DNs, mainly originating in A10 regions.

大鼠腹侧中脑多巴胺能前体细胞可在体外大量诱导分化成TH阳性的主要源自A10区的多巴胺能神经元。

AIM: Biological function and in vivo survival of differentiated dopaminergic neurons, and comparison to the transplantation of embryonic mesencephalic DNs for treating Parkinson's disease rats are seldom studied.

目的:目前对于体外诱导分化的多巴胺能神经元的生物学功能、体内存活状况,以及与胚胎中脑多巴胺能神经元移植治疗帕金森病大鼠的疗效比较方面尚缺乏深入的研究。

MAIN OUTCOME MEASURES: Morphologic changes of differentiated ventral mesencephalic precursors; Expression of DN-related common marker genes before and after the induced differentiation.

主要观察指标:①多巴胺能前体细胞诱导分化后形态变化。②常见多巴胺能神经元标记基因在诱导分化前后过程中的表达。

BACKGROUND: A series of studies have demonstrated that ventral mesencephalic dopamine precursors may differentiate into considerable dopaminergic neurons available for cell transplantation for Parkinson's disease.

摘要背景:一系列研究表明,腹侧中脑多巴胺能前体细胞可在体外经人工诱导分化为大量多巴胺能神经元,有望用于移植治疗帕金森病,但是其分子特征尚不明了。

Rat ventral mesencephalic precursors can be induced to differentiate into plenty of tyrosine hydroxylase-positive DNs, mainly originating in A10 regions.

大鼠腹侧中脑多巴胺能前体细胞可在体外大量诱导分化成酪氨酸羟化酶阳性的主要源自中脑腹侧被盖区(A10)的多巴胺能神经元。

Objective:To explore the clinical effect of sodium nitroprusside,dopamine with dobutamine in treatment of refractory heart failure of dilated cardiomyopathy.

目的:探讨硝普钠、多巴胺和多巴酚丁胺治疗扩张型心肌病顽固性心力衰竭的临床疗效。

After neurotoxin treatment, CR monkeys exhibited significantly higher levels of locomotor activity compared with control monkeys as well as higher levels of dopamine and DA metabolites in the striatal region.

神经毒素处理以后,热限制的猴子与对照组的猴子相比表现出更高的自发活动能力,并且多巴胺多巴胺代谢产物在纹状体也表现出非常高的水平。

We found that, in the ventral tegmental area of anesthetized rats, the population of presumed dopamine neurons that are excited by aversive stimuli is actually not dopaminergic.

作者发现在麻醉大鼠的腹侧被盖区中被推测对令人厌恶刺激产生反应的多巴胺能神经元群体实际上不是多巴胺能的。

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