多巴胺

Results Cloned glomus cells expressed high levels of tyrosine hydroxylase immunoreactivity and selectively released dopamine in culture.

这些克隆细胞几乎不表达多巴胺转运体而且抵抗多巴胺和MPTP介导的神经毒性。

It is caused by the degeneration of nigro-striatum dopaminergic neuron resulting in the reduction of dopamine and the hyperfunction of acetylcholine.

帕金森病（Parkinson's disease，PD）为神经系统变性疾病，主要的病理改变是黑质纹状体通路的多巴胺能神经元变性，导致多巴胺减少和乙酰胆碱系统功能亢进。

Parkinson's disease is a common neurodegenerative disease, which mainly affect the old age, characterized by tremor, muscle rigidity, bradykinesia and postural instability. It is caused by the degeneration of nigro-striatum dopaminergic neuron resulting in the reduction of dopamine and the hyperfunction of acetylcholine.

帕金森病（Parkinson's disease，PD）为神经系统变性疾病，主要的病理改变是黑质纹状体通路的多巴胺能神经元变性，导致多巴胺减少和乙酰胆碱系统功能亢进。

Although there was no significant difference in the rate of death between patients with shock who were treated with dopamine as the first-line vasopressor agent and those who were treated with norepinephrine, the use of dopamine was associated with a greater number of adverse events.

尽管在使用多巴胺或者去甲肾上腺素作为一线血管活性药物的病人中，死亡率并没有显著的统计学差别，但是多巴胺与一些不良事件相关。

The executive system, in contrast, is known to be carried outin the prefrontal cortex and dorsolateral prefrontal cortex,which are central to learning, planning, regulating impulses,and making rational decisions.

这些自动受体通常在它最初释放后&擦掉&自由多巴胺的总量。更少的自动受体意味著这些人在多巴胺引发刺激后，更可能有更&激烈&的行径。

In present study, we demonstrated that μ opioid receptor and D1 dopamine receptor could form heteromeric complexes in membranes preparation from HEK293T cells transiently cotransfected with both receptors and from mice striatum.

在本工作中，我们通过免疫共沉淀和BRET法证明，HEK293T细胞上瞬时表达的μ阿片受体和D1多巴胺受体能形成异源二聚体，并证实μ阿片受体和D1多巴胺受体异源二聚体存在于小鼠纹状体中。

The anatomical localizations indicate that Al receptor and Dl receptor coexist in strionigro-strioentopeduncular neurons, and A2a receptor and D2 receptor coexist in striopallidals neurons. The heteromeric complexes of Al/D1、A2a/D2 receptor provided the molecular basis for the functional interactions of Al/Di and A2a/D2 receptor.

腺苷A1受体和多巴胺D1受体以及腺苷A2a受体和多巴胺D2受体分别共存於基底神经节中纹状体向黑质和脚内核投射的神经元以及纹状体向苍白球投射的神经元内。A1/D1、A2a/D2受体形成受体异聚复合体构成了受体一受体之间相互作用的分子基础。

In present study, levels of dopamine 〓 and 〓 receptors and expression of the protein mRNAs in striatum were exarmined by the methods of immuno- histochemistry and in situ hybridization, respectively. It was found that mice treated by paraquat taken orally for four months displayed a marked hypoactive behavior.

本研究以口服给予小鼠百草枯的PD模型，采用免疫组织化学、原位杂交结合计算机图像处理分析技术，观察百草枯对纹状体区多巴胺〓受体、多巴胺〓受体蛋白含量和基因表达的影响。

The results of in situ hybridization and fluorescence quantitative PCR showed that the gene expression of dopamine receptors(including D1 and D2) in the prefrontal cortex and DRD1 in lentiform nucleus of SHR from the Kongsheng Zhenzhong Pill group is higher than that in the methylphenidate hydrochloride group and both groups are lower than that in the control group:the gene expression of dopamine receptors D2 in the lentiform nucleus from the methylphenidate hydrochloride group is higher than that in the Kongsheng Zhenzhong Pill group while both groups are lower than that from the control group.

原位杂交和荧光定量PCR表明，SHR大鼠前额叶皮质的多巴胺受体(包括D1和D2)和豆状核受体D1的基因表达，孔圣枕中丹组比盐酸哌甲酯组要高，且两者均低于对照组；豆状核多巴胺受体D2的基因表达，盐酸哌甲酯组要比孔圣枕中丹组高，且均低于对照组。

In experimental animals, exposure to a common herbicide, rotenone, induces features of Parkinsonism; mechanistically, rotenone-induced destruction of dopaminergic neurons has been attributed to its inhibition of the activity of neuronal mitochondrial complex Ⅰ.

例如，Greenamyre和他的同事在2000年报道了经大鼠颈静脉慢性灌流鱼藤酮复制了帕金森病的主要特征，包括选择性黑质纹状体多巴胺系统变性，Lewy小体样细胞浆包涵体形成和一些行为变化，例如运动减少和僵直等。从发病机制上考虑，鱼藤酮诱导的多巴胺神经通路损伤被认为是由鱼藤酮抑制线粒体复合体Ⅰ活性引起的。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐