多巴

The anatomical localizations indicate that Al receptor and Dl receptor coexist in strionigro-strioentopeduncular neurons, and A2a receptor and D2 receptor coexist in striopallidals neurons. The heteromeric complexes of Al/D1、A2a/D2 receptor provided the molecular basis for the functional interactions of Al/Di and A2a/D2 receptor.

腺苷A1受体和多巴胺D1受体以及腺苷A2a受体和多巴胺D2受体分别共存於基底神经节中纹状体向黑质和脚内核投射的神经元以及纹状体向苍白球投射的神经元内。A1/D1、A2a/D2受体形成受体异聚复合体构成了受体一受体之间相互作用的分子基础。

The role of dopamine deficiency in depression is suggested by the frequency of depression in patients with Parkinson's disease and the effect of reserpine, which depletes serotonin, norepinephrine, and dopamine, causing a hypoactive state in animals.

抑郁症多巴胺不足的角色，从帕金森病人抑郁频繁中得到提示，利血平有效，帕金森病消耗了 5-羟色胺，去甲肾上腺素和多巴胺，动物引起活动减退的情状。

In present study, levels of dopamine 〓 and 〓 receptors and expression of the protein mRNAs in striatum were exarmined by the methods of immuno- histochemistry and in situ hybridization, respectively. It was found that mice treated by paraquat taken orally for four months displayed a marked hypoactive behavior.

本研究以口服给予小鼠百草枯的PD模型，采用免疫组织化学、原位杂交结合计算机图像处理分析技术，观察百草枯对纹状体区多巴胺〓受体、多巴胺〓受体蛋白含量和基因表达的影响。

An isocratic HPLC assay was developed for simultaneous determination of levodopa methyl ester and levodopa in the hydrolysate of levodopa methylester.

采用等度高效液相分析方法同时检测左旋多巴甲酯及其水解产物左旋多巴，得到了一系列水解速率常数以及氢离子浓度和温度对水解反应的影响。

The results of in situ hybridization and fluorescence quantitative PCR showed that the gene expression of dopamine receptors(including D1 and D2) in the prefrontal cortex and DRD1 in lentiform nucleus of SHR from the Kongsheng Zhenzhong Pill group is higher than that in the methylphenidate hydrochloride group and both groups are lower than that in the control group:the gene expression of dopamine receptors D2 in the lentiform nucleus from the methylphenidate hydrochloride group is higher than that in the Kongsheng Zhenzhong Pill group while both groups are lower than that from the control group.

原位杂交和荧光定量PCR表明，SHR大鼠前额叶皮质的多巴胺受体(包括D1和D2)和豆状核受体D1的基因表达，孔圣枕中丹组比盐酸哌甲酯组要高，且两者均低于对照组；豆状核多巴胺受体D2的基因表达，盐酸哌甲酯组要比孔圣枕中丹组高，且均低于对照组。

In experimental animals, exposure to a common herbicide, rotenone, induces features of Parkinsonism; mechanistically, rotenone-induced destruction of dopaminergic neurons has been attributed to its inhibition of the activity of neuronal mitochondrial complex Ⅰ.

例如，Greenamyre和他的同事在2000年报道了经大鼠颈静脉慢性灌流鱼藤酮复制了帕金森病的主要特征，包括选择性黑质纹状体多巴胺系统变性，Lewy小体样细胞浆包涵体形成和一些行为变化，例如运动减少和僵直等。从发病机制上考虑，鱼藤酮诱导的多巴胺神经通路损伤被认为是由鱼藤酮抑制线粒体复合体Ⅰ活性引起的。

Mesencephalic neural stem cells of rats at different gestational days have different capabilities to differentiate towards dopaminergic neurons.

不同胎龄大鼠中脑的神经干细胞体外诱导向多巴胺能神经元分化的能力不同，以孕12 d诱导分化成多巴胺能神经元比例最高。

This study investigated the effect of transplantation of dopaminergic neurons differentiated from neural stem cells into Parkinson's disease rats, and compared to the transplantation of embryonic mesencephalic DNs.

观察神经干细胞诱导分化的多巴胺能神经元移植治疗帕金森病大鼠的作用，并与胚胎中脑多巴胺能神经元组织移植治疗帕金森病大鼠的疗效进行比较。

Rat ventral mesencephalic precursors can be induced to differentiate into plenty of tyrosine hydroxylase-positive DNs, mainly originating in A10 regions.

大鼠腹侧中脑多巴胺能前体细胞可在体外大量诱导分化成TH阳性的主要源自A10区的多巴胺能神经元。

AIM: Biological function and in vivo survival of differentiated dopaminergic neurons, and comparison to the transplantation of embryonic mesencephalic DNs for treating Parkinson's disease rats are seldom studied.

目的：目前对于体外诱导分化的多巴胺能神经元的生物学功能、体内存活状况，以及与胚胎中脑多巴胺能神经元移植治疗帕金森病大鼠的疗效比较方面尚缺乏深入的研究。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。