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Objective To investigate the degeneration of dopaminergic neurons induced by MPP+ in mouse mesencephalic dissociated culture and establish the cell model for parkinson'[KG-*3]s disease research in vitro.

目的: 探讨1-甲基-4-苯基-四氢吡啶离子对小鼠胚胎中脑原代培养多巴胺能神经元的毒性作用及其机制。

Parkinson's disease is one of aging diseases, of which progressive degeneration of the mesencephalic dopaminergic neuron is its pathologic hallmark.

帕金森氏病(Parkinson's disease,PD)是以中脑多巴胺神经元进行性退变为主要病理特征的老年性疾病。

Micellar effects of dopamine have also been studied by cyclovicltammetric method.

这与弱碱性的多巴胺在一定pH范围内形成的正离子结构有关。

However, the role of microglia in rotenone-induced neurodegeneration has not been reported.

但是,在鱼藤酮诱导的多巴胺神经元变性过程中,小胶质细胞的作用尚未可知。

Methods: 1. A model of Transwell has been developed for the co-culture nearly pure microglia cells and dopaminergic neurons.

研究方法 1、用原代培养的方法建立小胶质细胞与中脑多巴胺能神经元体外培养的Transwell细胞模型。

Acute Map also cause dopamine increases in medial prefrontal cortex and neostriatum, which results in the increasing of locomotor's activity and stereotypic behavior.

急性甲基安非他命也会引起额脑及纹状体中的多巴胺浓度增加,继而导致活动力上升及出现刻板行为和敏感化现象。

AIM To study the mechanism of dopaminergic neuronal death of Parkinson's diseases.

目的 研究帕金森病多巴胺能神经元的死亡机制。

It has been confirmed that the ratio of DAT to VMAT2 could dictate a neurone's sensitivity to dopaminergic toxins.

有研究证实,DAT和VMAT2的比值能够反映神经元对多巴胺能神经毒物的敏感性。

BACKGROUND: It is of significance to study the direct differentiation of human bone marrow mesenchymal stem cells into dopaminergic neurons and their functional characteristics for the treatment of neuropsychiatric disease such as Parkinson's disease with cell transplantation.

背景:研究人骨髓间充质干细胞定向分化为多巴胺神经元及分化后细胞的功能特征,对细胞移植治疗包括帕金森病在内的神经精神性疾病具有重要临床意义。

Objective:To evaluate the efficiency of Nitroprusside combined Dopamine in treating the refractory heart failure.

目的:探讨硝普钠与多巴胺联合治疗对各种心脏病引起的顽固性心衰患者的疗效。

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