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At baseline and on day 1, 3, 7, 14, 21 following MPP+ injection, the degree of microglial activation was examined by detecting the immunodensity of OX-42 in the substantia nigra. The number of viable dopaminergic neurons was determined by measuring tyrosine hydroxylase positive neurons in the SN. Behavioral performances were evaluated by counting the number of rotations induced by apomorphine, calculating scores of forelimb akinesia and vibrissae-elicited forelimb placing asymmetry.

分别在基线、MPP+注射后第1、3、7、14、21天时通过测定黑质区域OX-42的免疫荧光强度评定小胶质细胞的激活程度,测定酪氨酸羟化酶的表达情况评定存活多巴胺神经元的数量;通过阿朴吗啡诱导的旋转行为、前肢跨步及触须引发的不对称放置试验得分测评行为学表现。

Our study was to explore the relationship between high myopia of albino guinea pig and the expression of retinal dopamine.

目的 观察白化豚鼠视网膜多巴胺的表达,探讨其视网膜DA与高度近视的关联。

The Company was responsible for framing Lincoln, and they did so because of Lincoln's father, Aldo Burrows, and his former connections to the company.

公司负责诬陷林肯,他们这样做因为林肯的父亲奥尔多·巴罗斯,他的之前的和公司的联系。

At present there is no effective therapeutics to treat PD except the allopathy. The discovery of neural stem cells in the adult mammalian brain provides a new chance to effect a radical cure on PD. But how to make the limited neural stem cells proliferating enough and differentiating into the dopaminergic neurons which can repair the nigrostriatal pathway and help to eliminate the PD symptoms becomes an urgent problem.

成年动物脑内神经干细胞的发现为根治帕金森病提供了新的细胞源泉,但如何使有限的神经干细胞增殖到足够数量并转化为多巴胺能神经元,使之能够修复黑质纹状体通路,逆转帕金森病临床症状,是目前亟待解决的问题。

In the early stage of STZ diabetic, administering BDNF protein into the vitreous cavities can increase TH protein levels and the density of dopaminergic amacrine cells in the STZ rats' retina.

在STZ糖尿病大鼠糖尿病早期,玻璃体腔内注射BDNF可提高视网膜中TH的水平,提高多巴胺能无长突细胞的数目。

RESULTS: The protein levels of TH, the number of positive staining dopaminergic amacrine cells and the staining gray scale of experimental group without BDNF were lower statistically.

结果:实验组糖尿病大鼠未注射BDNF眼视网膜中TH蛋白水平降低,多巴胺能无长突细胞计数及灰度低于对照组,均有统计学差异。

AIM: To observe the changes of tyrosine hydroxylase protein levels and the density of dopaminergic amacrine cells before and after the administering brain derived neurotrophic factor protein into the vitreous cavities of streptozotocin reduced Wistar diabetic rats.

目的:观察玻璃体腔内注射脑源性神经营养因子(Brain derived neurotrophic factor,BDNF)前后STZ糖尿病大鼠视网膜中酪氨酸羟化酶(tyrosine hydroxylase,TH)的水平及多巴胺能无长突细胞数目的变化。

METHODS: Adult male Wistar rats, 9 weeks of age, were injected intraperitoneally with STZ to create diabetes. At 2 week after the models were created, BDNF protein was administered into the vitreous cavities of rats. At 4 week after the models were created, the rats were killed and the retina was removed for Western blotting and Whole-mount immunohistochemistry for TH to observe the changes of TH and dopaminergic amacrine cells in retina.

9周龄Wistar大鼠,链脲佐菌素(streptozotocin,STZ)腹腔注射,制成糖尿病模型,于模型建立2wk后,大鼠眼玻璃体内注射BDNF溶液,于模型建立4wk后,处死大鼠,取出眼球,取视网膜组织进行Western blotting及视网膜铺片免疫组织化学染色检测,观察视网膜中TH水平的变化,从而反映糖尿病大鼠视网膜中多巴胺能无长突细胞水平的变化。

Objective To observe the effects of levodopa on strabismic amblyopia model eyes in cats, and explore amblyopia pathogenesis.

目的 观察左旋多巴对猫弱视眼模型的作用,以探讨弱视的发病机理。

The monoamine percentage of the total amine content was higher than 20%.

多巴胺的百分比总胺含量高于20%。

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But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊!不用提了。提到肉,真是糟透了。

Tristan, I have nowhere to send this letter and no reason to believe you wish to receive it.

Tristan ,我不知道把这信寄到哪里,也不知道你是否想收到它。