多因子的

objective to raise the level of regarding congnition,prevention,diagnosis and therapy on multiple organ dysfunction syndrome.methods report the process and correlative therapy on one case who occured with mods involving 6 organs after hemorrhagic shock lead to heartbeat and respiration stopping suddenly and resuscitated resulting in left nephrostome titanium nip falled off accidentally from left kidney lymphatic fastening.at the same time,the author reviewed correlative literature and introduce the investigative progress about mods.results one case who happened with mods following hemorrhagic shock,heartbeat and respiration stopped suddenly was diagnozed and resuscitaed.6 organ dysfuncted including brain,heart,lung,liver,kidney and the digestive system.after being given therapy integrated chinese and western medicines,allopathy and nutritional treatment,all circadian parameters of the case came back in gear and discharged at last.conclusion the mechanism about mods is very complicated.because of serious infection,hurt and oxygen-lack,excessive inflammatery reaction activates multifarious cell factors and inflammatery mediums,which improve the happen-rate of mods.wiping off pathogeny,providing life-sustain treatment and recognising sirs and mods in time and adopting corresponding therapy,such as treatment integrated chinese and western medicines,can improve the hit-rate of cure on mods.

作者：王静恩，蔡金芳，王志华，谢晓洪多器官功能障碍综合征；中西医结合；治疗；休克，出血性目的提高对多器官功能障碍综合征（multiple organ dysfunction syndrome，mods）的认识、预防、诊断、治疗水平。方法报告成功抢救1例经腹腔镜左肾淋巴管结扎手术后左肾静脉钛夹意外脱落失血性休克，导致心跳呼吸骤停复苏后再手术并发mods累及6个脏器功能衰竭过程及有关治疗，并复习相关文献，介绍目前关于mods的研究进展。结果确诊1例因失血性休克心跳呼吸骤停复苏后并发mods，累及脑、心、肺、肝、肾、血液、胃肠等6个脏器。经积极采取中西医结合对症、支持救治，各生理指标全部恢复正常，康复出院。结论 mods的发生机制非常复杂，在严重感染、创伤、缺氧等打击下，失控的过度炎症反应激活多种细胞因子和炎症介质的释放，使mods发生率升高。尽早去除病因，尽早给予各种生命支持治疗，尽早对可能发生全身炎症反应综合征、mods识别并给予干预治疗，包括中西医结合治疗能改善mods的救治成功率。

Based on seismic source spectrum solution by multi-station and multi-event coda method, applying Brune seismic source model, we have got the source factors and spectra of 48 small earthquakes occurred before and after the Douhe earthquake of October 6 in 1995. The seismic moments, corner frequencies and stress drops are estimated from the spectra, and their correlation and variation with time before and after the Douhe earthquake are discussed.

在震源谱的多台多震尾波解法的基础上，应用Brune震源模型，求解1995年10月6日陡河ML5.9地震前后在其周围发生的48次小地震的震源因子和震源波谱，进而估算了地震矩、拐角频率和应力降，并讨论了它们之间的相互关系和在陡河地震前后随时间的变化。

The long-term opening of mitochondria permeability transition pore results in the release of cytochrome C, apoptosis inducing factors, Ca2+ and other apoptosis factors into cytoplasm, which can destruct the whole cell structure and function by activating the main member of apoptosis protein family——caspase, or destroying the intranuclear chromoplasm independently, or affecting other protein relying on Ca2+, and finally lead to the formation of apoptotic body.

线粒体是真核生物能量和代谢的中心，也是细胞凋亡信号传导途径中起关键作用的细胞器，越来越多的研究表明，在凋亡信号的刺激下，线粒体发生膨胀，其外膜膜电位降低，外膜破裂后释放出膜间隙的诸多凋亡效应因子，在细胞凋亡中起着主开关的作用。

PAL activity, chitinase activity, total Polyphenol content and total Flavonoids content in soybean leaves induced by the same crude toxin and race were similar, it stated that the crude toxin is an important factor which can induce resistant substances, but the induced speed and the induced intensity by the crude toxin and conidium were different. Firstly, the induced speed of crude toxin which induced PAL activity and total Flavonoids content of resistant soybean varieties was faster than speed of C.

同一生理小种的粗毒素与灰斑病菌对大豆叶片内PAL活性、总多酚类含量、总黄酮含量以及几丁质酶活性等几种生化指标均表现出相似的诱导作用，由此可推断粗毒素是诱导大豆叶片内的PAL活性、总多酚含量、总黄酮含量以及几丁质酶活性产生变化的主要生物因子，只是二者在对抗性不同的大豆品种的诱导速度及强度上存在一定的差异。

Several anti-tumor cell lines and carbonic anhydrase Ⅱ model were established. More than 10000 compounds and extracts from plants were screened using these models and about 10 compounds showed strong inhibitory activities. Two species of plants Inula helianthus-aquatica and Saussurea deltoidea were chosen to investigate chemical and bioactivity constituents based on the results of screening of extracts and fractions. 58 compounds were isolated and identified from these two plants, 6 compounds were found to be new and 14 compounds showed anti-tumor activities. We also studied the anti-tumor mechanism of the compound bigelovin isolated from Inula helianthus-aquatica. Bigelovin was found with apoptotic activity against cell line U266 by lowering the amount of important transcription factor E2F-1 which inhibits the cell cycle at G0/G1 stage. Docking study on 7 natural new phenolic inhibitors of CA Ⅱ and 3D-QSAR study on 61 sulfonamide inhibitors of CA Ⅱwere also investigated. The calculated results were in good correlation with experimental results.

基于以上两种重要疾病和研究组方向，本论文工作开展了多个肿瘤细胞株和碳酸酐酶Ⅱ靶标模型的建立和筛选工作，累计筛选1万多个/次样品，发现10余个活性较强化合物；从粗提取物筛选结果中选取两种抗肿瘤活性强的菊科植物水朝阳旋覆花(Inula helianthus-aquatica)和三角叶凤毛菊进行了系统化学和活性成分研究，分离鉴定了58个化合物，发现6个新化合物和14个抗肿瘤活性化合物；通过合作对水朝阳旋覆花中活性较强的bigelovin进行了抗肿瘤作用机制研究，发现它可能是通过降低G2期重要的转录因子E2F-1，致使细胞周期阻滞在G0/G1期，引起多发性骨髓瘤U266细胞凋亡；开展了7个新的天然酚类CAⅡ抑制剂的对接研究和61个合成的系列磺酰胺类CAⅡ抑制剂的3D-QSAR分析，结果表明计算与实验一致。

Deep evolution is an aggregate of many kinds of evolutions; it is a multifaced god, a creator with many arms, working by many methods, of which natural selection of variation is perhaps the most universal factor.

深奥的进化过程，实际上是由多种类型的进化过程所叠加在一起而总和而成的，它是那种具有多副面孔的神，一位长有多条臂膀的创造者，它通过多种不同的方法来进行它的工作，而在这些方法之中，对变异的自然选择，也许是一种应用最为广泛的因子而已。

Deep evolution is an aggregate of many kinds of evolutions; it is a multifaced god, a creator with many arms, working by many methods, of which natural selection of variation is perhaps the most universal factor.

这种深入的进化过程，实际上是由多种类型的进化过程所叠加在一起而总和而成的，它是那种具有多副面孔的神，一位具有多条臂膀的创造者，它通过多种不同的方法来进行它的工作，而在这些方法之中，对改变的自然选择，也许是一种应用最为广泛的因子而已。

On the basis of summarizing the application of the Penman-Monteith model in forest underlying surface, the evaluating method and significance of many parameters were expounded. The calculating methods of the key parameters were discussed including net radiation, aerodynamics resistance and canopy layer stomatic resistance, some problems were analyzed and some suggestions were given for practical application of this model in forest evaportranspiration research.

中文摘要： Penman—Monteith公式是在蒸散研究中应用最多，也是变化形式最多的方法，该文在对目前Penman—Monteith模型在森林下垫面中应用总结的基础上，阐述了其中众多参数的意义和常用的确定方法，着重探讨了影响该模型精确性的关键因子净辐射、空气动力学阻力和冠层阻力的计算方法，并分析了Penman—Monteith模型在实际应用中存在的一些问题，提出了该模型在今后森林蒸散研究中发展的思路。

Porous asphalt concrete is composed of asphalt mastic, coarse aggregate, thin aggregate, stuff and admixture. Such a combination is expected to fully integrate these materials. In this way, the function of interlocking among particles can be performed, a firm net of porous asphalt framework formed and the ability to resist rut and wear developed. The different mixture results in different effects; the quality is so complicated that the factors that cause damage are multiple. Therefore, it is bothersome to choose one material that can be adjusted to various conditions everywhere, such as the traffic volume, load and the weather. The current study mainly investigates and analyzes the main factor that caused flaws after the roads paved with porous asphalt concrete have been open. The analysis aims to search for the best solutions, promote the quality, prolong its availability and finally reach the purpose of complete use.

多孔隙沥青混凝土依其组成材料由沥青胶泥、粗粒料、细粒料、填充料、添加物等组成，目的是希望藉由以上材料的组合能充分接触，发挥颗粒间互锁作用，形成牢固的连锁网的沥青混凝土架构，发挥粒料本身良好的抗车辙及抗磨损之能力，因添加物的不同所发挥出的效果亦不同，其性质甚为复杂，造成损坏之因素亦属多重性，要择其适用於各地迥异之各种条件，如交通量、荷载及气候环境等因子，极为繁琐，本研究主要探讨及分析已铺筑之多孔隙沥青混凝土铺面，经通车后产生之缺失主要因素，以寻求其最佳解决方案，提升品质与延长使用寿命，进而达到全面使用。

The effect of single factor indicated that lower concentration of tea polyphenols and oxidant, temperature, ester proportion and pH value, shorter reaction time were favorable to the formation and accumulation of TFs, higher concentration of tea polyphenols, temperature, ester proportion and pH value, longer reaction time were favorable to the formation and accumulation of TRs.

借助参数模型研究各参数因子对TFs和TRs形成的影响，结果表明：茶多酚浓度、温度、酯比例及pH值对TFs和TRs形成与积累均有显著影响，反应时间对TFs影响显著，氧化剂对TRs影响显著；单因素效应显示：较低的茶多酚和氧化剂浓度、适当的低温和较短的时间、低的酯比例和pH较有利于TFs形成与积累，而有利于TRs形成与积累的参数则相反。

The basic concept of FOP can be summarized as to further optimize effective prescription according to the standard of curative effects and with the aid of modern science and technology and theories of traditional Chinese medicine.

其基本内涵可概括为：以确有疗效的中药复方为研究对象，以现代科学技术和传统中医药理论为技术支持，以该复方所治病证的药效响应为评价标准，以优化重组疗效更优的新复方为研究目的。

Ever since our world has been a world, native forests have been indiscriminately exploited by man.

自从我们的世界一直是世界原生森林被任意剥削人。